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发现驱动中医药研究的新范式
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作者 杨永清 尹磊淼 +2 位作者 王宇 徐玉东 陈艳焦 《中国科学基金》 CSCD 北大核心 2024年第3期412-418,共7页
发挥中医药原创优势、推动我国生命科学实现创新突破是国家需求,但如何挖掘中医药的原创优势,还需要进一步提升思想认知,用现代科学解读中医药学原理。本文在建国以来中医药实证性研究的基础上,正本清源,传承精华,厘清中医学中未加工事... 发挥中医药原创优势、推动我国生命科学实现创新突破是国家需求,但如何挖掘中医药的原创优势,还需要进一步提升思想认知,用现代科学解读中医药学原理。本文在建国以来中医药实证性研究的基础上,正本清源,传承精华,厘清中医学中未加工事实与理性推演之间的关系,发现其中的科学事实;阐幽明微,守正创新,应用现代科学技术,发现中医理论与效应的独特原创优势,从中医出发为医学与生命科学做贡献,解决生物医药“卡脖子”问题两方面,面向未来,列举例证,发现驱动中医药研究的新范式:在厘清古籍医学事实、明确中医药临床效应的基础上,深入研究中国医学中尚不能被现代医学解释的独特生物学现象和过程,以期揭示新的生理现象、阐释新的病理机制、创建新的治疗策略,更加充分地发挥中医药原创优势,推动我国生物医学实现创新突破。 展开更多
关键词 中医药 生命科学 研究范式 靶标发现
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A Valence Electron Structure Criterion of Ionic Conductivity of Sr- and Mg-doped LaGaO_3 Ceramics 被引量:1
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作者 Min SHI Ning LIU +3 位作者 yudong xu Can WANG Yupeng YUAN P.Majewski 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2006年第2期215-219,共5页
The valence electron structures of Sr- and Mg-doped LaGaO3 ceramics with different compositions were calculated by Empirical Electron Theory of Solids and Molecules (EET). A criterion for the ionic conductivity was ... The valence electron structures of Sr- and Mg-doped LaGaO3 ceramics with different compositions were calculated by Empirical Electron Theory of Solids and Molecules (EET). A criterion for the ionic conductivity was proposed, i.e. the 1/(nAnB) increases with increasing the ionic conductivity when x or y〈20% (in molar fraction). 展开更多
关键词 Empirical electron theory of solids and molecules (EET) Valence electron structure LaGaO3 ceramics Ionic conductivity
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源自针灸的靶标发现之科学路径:以针刺防治哮喘为例 被引量:11
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作者 杨永清 尹磊淼 +3 位作者 朱维良 王宇 徐玉东 陈艳焦 《科学通报》 EI CAS CSCD 北大核心 2020年第32期3520-3525,共6页
针灸学如何传承精华,实现守正创新.本文在长期工作积累基础上,系统建立了源自针灸的靶标发现科学路径,包括经验传承、临床疗效、效应调节、生物过程、物质基础、靶标发现,并对未来可期的新药创制进行了展望.
关键词 经验传承 新药创制 临床疗效 针灸学 靶标发现 守正创新 科学路径 针刺防治
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SYNTHESIS OF STRONTIUM-AND MAGNESIUM-DOPED LANTHANUM GALLATE BY GLYCINE-NITRATE COMBUSTION METHOD 被引量:2
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作者 Ning Liu Yupeng Yuan +3 位作者 Min Shi yudong xu P. Majewsk F. Aldinger 《China Particuology》 SCIE EI CAS CSCD 2006年第1期9-12,共4页
Sr- and Mg-doped lanthanum gallate powders with the composition of La0.55Sr0.15Ga0.85Mg0.15O2.85were synthesized by a glycine-nitrate combustion method. Powders prepared under different fuel combustion conditions were... Sr- and Mg-doped lanthanum gallate powders with the composition of La0.55Sr0.15Ga0.85Mg0.15O2.85were synthesized by a glycine-nitrate combustion method. Powders prepared under different fuel combustion conditions were investigated by XRD and TEM. The results show that, under slightly rich fuel condition, the product powders contain less impurity phases, and powders prepared by the glycine-nitrate combustion contain far less impurity phases and have smaller particle sizes than those prepared by solid-state reaction method or acrylamide polymerization technique. 展开更多
关键词 glycine-nitrate combustion method solid-state reaction method acrylamide polymerization technique phase constitution
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Difference in calcium ion precipitation between free and immobilized Halovibrio mesolongii HMY2
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作者 Huaxiao Yan Meiyu Huang +10 位作者 Jihan Wang Heding Geng Xiyu Zhang Ziyang Qiu Yongliang Dai Zuozhen Han yudong xu Long Meng Lanmei Zhao Maurice E.Tucker Hui Zhao 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2022年第12期184-200,共17页
Biomineralization has become a research focus in wastewater treatment due to its much lower costs compared to traditional methods.However,the low sodium chloride(NaCl)-tolerance of bacteria limits applications to only... Biomineralization has become a research focus in wastewater treatment due to its much lower costs compared to traditional methods.However,the low sodium chloride(NaCl)-tolerance of bacteria limits applications to only water with low NaCl concentrations.Here,calcium ions in hypersaline wastewater(10%NaCl)were precipitated by free and immobilized Halovibrio mesolongii HMY2 bacteria and the differences between them were determined.The results show that calcium ions can be transformed into several types of calcium carbonate with a range of morphologies,abundant organic functional groups(C-H,C-O-C,C=O,etc),protein secondary structures(β-sheet,α-helix,3_(10)helix,andβ-turn),P=O and S-H indicated by P2p and S2p,and more negativeδ^(13)C_(PDB)(‰)values(-16.8‰to-18.4‰).The optimal conditions for the immobilized bacteria were determined by doing experiments with six factors and five levels and using response surface method.Under the action of two groups of immobilized bacteria prepared under the optimal conditions,by the 10^(th)day,Ca^(2+)ion precipitation ratios had increased to 79%-89%and 80%-88%with changes in magnesium ion cencentrations.Magnesium ions can significantly inhibit the calcium ion precipitation,and this inhibitory effect can be decreased under the action of immobilized bacteria.Minerals induced by immobilized bacteria always aggregated together,had higher contents of Mg,P,and S,lower stable carbon isotope values and less well-developed protein secondary structures.This study demonstrates an economic and eco-friendly method for recycling calcium ions in hypersaline wastewater,providing an easy step in the process of desalination. 展开更多
关键词 BIOMINERALIZATION Halovibrio mesolongii Hypersaline wastewater Calcium ion removal Intracellular aragonite
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