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Quantitative Study on Morphological Change Characteristics of Tonle Sap Lake Based on DEM
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作者 Yan Huang Yifei Tian +6 位作者 Changwen Li wu Liu Nan Zhang Haiyang Wang yue wu Wanting Feng Yifan Yu 《Open Journal of Modern Hydrology》 CAS 2024年第1期1-13,共13页
Lake is an important part of the natural ecosystem, and its morphological characteristics reflect the capacity of lake regulation and storage, the strength of material migration, and the characteristics of shoreline d... Lake is an important part of the natural ecosystem, and its morphological characteristics reflect the capacity of lake regulation and storage, the strength of material migration, and the characteristics of shoreline development. In most existing studies, remote sensing images are used to quantify the morphological characteristics of lakes. However, the extraction accuracy of lake water is greatly affected by cloud cover and vegetation cover, and the inversion accuracy of lake elevation data is poor, which cannot accurately describe the response relationship of lake landscape morphology with water level change. Therefore, this paper takes Tonle Sap Lake as the research object, which is the largest natural freshwater lake in Southeast Asia. DEM is constructed based on high-resolution measured topographic data, and morphological indicators such as lake area, lake shoreline length, perimeter area ratio, longest axis length, maximum width, shoreline development index, lake shape complexity, compactness ratio and form ratio are adopted to researching the evolution law of high water overflows and low water outbursts quantitatively, and clarifying the variation characteristics of landscape morphology with water level gradient in Tonle Sap Lake. The research results have important theoretical significance for the scientific utilization of Tonle Sap Lake water resources and the protection of the lake ecosystem. 展开更多
关键词 Tonle Sap Lake DEM Geometrical Morphology Variation Characteristic
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Pericytes protect rats and mice from sepsis-induced injuries by maintaining vascular reactivity and barrier function:implication of miRNAs and microvesicles 被引量:1
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作者 Zi-Sen Zhang Yi-Yan Liu +10 位作者 Shuang-Shuang He Dai-Qin Bao Hong-Chen Wang Jie Zhang Xiao-Yong Peng Jia-Tao Zang Yu Zhu yue wu Qing-Hui Li Tao Li Liang-Ming Liu 《Military Medical Research》 SCIE CAS CSCD 2024年第1期1-18,共18页
Background Vascular hyporeactivity and leakage are key pathophysiologic features that produce multi-organ damage upon sepsis.We hypothesized that pericytes,a group of pluripotent cells that maintain vascular integrity... Background Vascular hyporeactivity and leakage are key pathophysiologic features that produce multi-organ damage upon sepsis.We hypothesized that pericytes,a group of pluripotent cells that maintain vascular integrity and tension,are protective against sepsis via regulating vascular reactivity and permeability.Methods We conducted a series of in vivo experiments using wild-type(WT),platelet-derived growth factor receptor-β(PDGFR-β)-Cre+mT/mG transgenic mice and Tie2-Cre+Cx43^(flox/flox)mice to examine the relative contribution of pericytes in sepsis,either induced by cecal ligation and puncture(CLP)or lipopolysaccharide(LPS)challenge.In a separate set of experiments with Sprague-Dawley(SD)rats,pericytes were depleted using CP-673451,a selective PDGFR-βinhibitor,at a dosage of 40 mg/(kg·d)for 7 consecutive days.Cultured pericytes,vascular endothelial cells(VECs)and vascular smooth muscle cells(VSMCs)were used for mechanistic investigations.The effects of pericytes and pericyte-derived microvesicles(PCMVs)and candidate miRNAs on vascular reactivity and barrier function were also examined.Results CLP and LPS induced severe injury/loss of pericytes,vascular hyporeactivity and leakage(P<0.05).Transplantation with exogenous pericytes protected vascular reactivity and barrier function via microvessel colonization(P<0.05).Cx43 knockout in either pericytes or VECs reduced pericyte colonization in microvessels(P<0.05).Additionally,PCMVs transferred miR-145 and miR-132 to VSMCs and VECs,respectively,exerting a protective effect on vascular reactivity and barrier function after sepsis(P<0.05).miR-145 primarily improved the contractile response of VSMCs by activating the sphingosine kinase 2(Sphk2)/sphingosine-1-phosphate receptor(S1PR)1/phosphorylation of myosin light chain 20 pathway,whereas miR-132 effectively improved the barrier function of VECs by activating the Sphk2/S1PR2/zonula occludens-1 and vascular endothelial-cadherin pathways.Conclusions Pericytes are protective against sepsis through regulating vascular reactivity and barrier function.Possible mechanisms include both direct colonization of microvasculature and secretion of PCMVs. 展开更多
关键词 PERICYTE Vascular reactivity Vascular permeability CX43 MICROVESICLE
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Deep tectonics and seismogenic mechanisms of the seismic source zone of the Jishishan M_(s)6.2 earthquake on December 18,2023,at the northeast margin of the Tibetan Plateau 被引量:1
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作者 Qiong Wang ShuYu Li +3 位作者 XinYi Li yue wu PanPan Zhao Yuan Gao 《Earth and Planetary Physics》 EI CAS CSCD 2024年第3期514-521,共8页
On December 18,2023,an M_(s)6.2 earthquake occurred in Jishishan,Gansu Province,China.This earthquake happened in the eastern region of the Qilian Orogenic Belt,which is situated at the forefront of the NE margin of t... On December 18,2023,an M_(s)6.2 earthquake occurred in Jishishan,Gansu Province,China.This earthquake happened in the eastern region of the Qilian Orogenic Belt,which is situated at the forefront of the NE margin of the Tibetan Plateau(i.e.,Qinghai-Tibet Plateau),encompassing a rhombic-shaped area that intersects the Qilian-Qaidam Basin,Alxa Block,Ordos Block,and South China Block.In this study,we analyzed the deep tectonic pattern of the Jishishan earthquake by incorporating data on the crustal thickness,velocity structure,global navigation satellite system(GNSS)strain field,and anisotropy.We discovered that the location of the earthquake was related to changes in the crustal structure.The results showed that the Jishishan M_(s)6.2 earthquake occurred in a unique position,with rapid changes in the crustal thickness,Vp/Vs,phase velocity,and S-wave velocity.The epicenter of the earthquake was situated at the transition zone between high and low velocities and was in proximity to a low-velocity region.Additionally,the source area is flanked by two high-velocity anomalies from the east and west.The principal compressive strain orientation near the Lajishan Fault is primarily in the NNE and NE directions,which align with the principal compressive stress direction in this region.In some areas of the Lajishan Fault,the principal compressive strain orientations show the NNW direction,consistent with the direction of the upper crustal fast-wave polarization from local earthquakes and the phase velocity azimuthal anisotropy.These features underscore the relationship between the occurrence of the Jishishan M_(s)6.2 earthquake and the deep inhomogeneous structure and deep tectonic characteristics.The NE margin of the Tibetan Plateau was thickened by crustal extension in the process of northeastward expansion,and the middle and lower crustal materials underwent structural deformation and may have been filled with salt-containing fluids during the extension process.The presence of this weak layer makes it easier for strong earthquakes to occur through the release of overlying rigid crustal stresses.However,it is unlikely that an earthquake of comparable or larger magnitude would occur in the short term(e.g.,in one year)at the Jishishan east margin fault. 展开更多
关键词 Jishishan M_(s)6.2 earthquake crustal structure anisotropy stress and strain seismogenic mechanism northeast margin of the Tibetan Plateau
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有机-无机杂化材料动力学与热力学转化以及荧光信息防伪应用研究——介绍一个综合化学实验
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作者 吴越 李钧 +3 位作者 张波 杨燕 李海波 张宪玺 《大学化学》 CAS 2024年第6期390-399,共10页
有机-无机杂化发光材料易于调控的空间结构和发光性质,在发光防伪领域备受青睐。本实验基于Sb(Ⅲ)掺杂Bi(Ⅲ)基零维有机-无机杂化金属卤化物,利用不同的晶体生长方式实现动力学产物(化合物1)向热力学产物(化合物2)的转变,采用X-射线粉... 有机-无机杂化发光材料易于调控的空间结构和发光性质,在发光防伪领域备受青睐。本实验基于Sb(Ⅲ)掺杂Bi(Ⅲ)基零维有机-无机杂化金属卤化物,利用不同的晶体生长方式实现动力学产物(化合物1)向热力学产物(化合物2)的转变,采用X-射线粉末衍射和荧光光度法分别对其进行了物相表征和光学性能测试,二者表现出截然不同的物相与光物理性质。化合物2在蒸馏水的作用下实现荧光淬灭,而且具有很强的反水性。基于化合物2出色的发光变色性质,制作了简易的可水写荧光信息防伪板/纸。本实验充分体现了“结构决定性质”的专业理论、“学以致用”的教学理念。该实验设计与实践旨在培养学生创新思维,提高其分析和解决实际问题的能力。 展开更多
关键词 Sb(Ⅲ)掺杂Bi(Ⅲ)基杂卤化物 光致发光 动力学与热力学转化 水致变色 可写荧光防伪应用
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Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation
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作者 Yi Ji Chaoyi Yang +7 位作者 Xuerui Pang Yibing Yan yue wu Zhi Geng Wenjie Hu Panpan Hu Xingqi wu Kai Wang 《Neural Regeneration Research》 SCIE CAS 2025年第2期326-342,共17页
Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and homeostasis.The Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neur... Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and homeostasis.The Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients incapacitated.Repetitive transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological conditions.Over the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and connectivity.It has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological insult.However,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of studies.This study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated mechanisms.This review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s disease.Apoptotic mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also highlighted.Finally,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations. 展开更多
关键词 Alzheimer’s disease amyloid deposition apoptotic mechanisms BIOMARKER neural regeneration NEURODEGENERATION repetitive transcranial magnetic stimulation synaptic plasticity
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Effect of chemical regulators on the recovery of leaf physiology,dry matter accumulation and translocation,and yield-related characteristics in winter wheat following dry-hot wind
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作者 Yanan Xu yue wu +5 位作者 Yan Han Jiqing Song Wenying Zhang Wei Han Binhui Liu Wenbo Bai 《Journal of Integrative Agriculture》 SCIE CSCD 2024年第1期108-121,共14页
Dry-hot wind stress causes losses in wheat productivity in major growing regions worldwide,especially winter wheat in the Huang-Huai-Hai Plain of China,and both the occurrence and severity of such events are likely to... Dry-hot wind stress causes losses in wheat productivity in major growing regions worldwide,especially winter wheat in the Huang-Huai-Hai Plain of China,and both the occurrence and severity of such events are likely to increase with global climate change.To investigate the recovery of physiological functions and yield formation using a new noncommercial chemical regulator(NCR)following dry-hot wind stress,we conducted a three-year field experiment(2018-2021)with sprayed treatments of tap water(control),monopotassium phosphate(CKP),NCR at both the jointing and flowering stages(CFS),and NCR only at the jointing stage(FSJ)or flowering stage(FSF).The leaf physiology,biomass accumulation and translocation,grain-filling process,and yield components in winter wheat were assessed.Among the single spraying treatments,the FSJ treatment was beneficial for the accumulation of dry matter before anthesis,as well as larger increases in the maximum grain-filling rate and mean grain-filling rate.The FSF treatment performed better in maintaining a high relative chlorophyll content as indicated by the SPAD value,and a low rate of excised leaf water loss in flag leaves,promoting dry matter accumulation and the contribution to grain after anthesis,prolonging the duration of grain filling,and causing the period until the maximum grain-filling rate reached earlier.The CFS treatment was better than any other treatments in relieving the effects of dry-hot wind.The exogenous NCR treatments significantly increased grain yields by 12.45-18.20% in 2018-2019,8.89-13.82% in 2019-2020,and 8.10-9.00% in 2020-2021.The conventional measure of the CKP treatment only increased grain yield by 6.69% in 2020-2021.The CFS treatment had the greatest mitigating effect on yield loss under dry-hot wind stress,followed by the FSF and FSJ treatments,and the CKP treatment only had a minimal effect.In summary,the CFS treatment could be used as the main chemical control measure for wheat stress resistance and yield stability in areas with a high incidence of dry-hot wind.This treatment can effectively regulate green retention and the water status of leaves,promote dry matter accumulation and efficient translocation,improve the grain-filling process,and ultimately reduce yield losses. 展开更多
关键词 preparation stress foliar spraying GRAIN-FILLING REMOBILIZATION
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Rational design of new in situ reduction of Ni(II)catalytic system for low-cost and large-scale preparation of porous aromatic frameworks
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作者 Shanshan Wang yue wu +3 位作者 Wenxiang Zhang Hao Ren Guangshan Zhu Heping Ma 《Carbon Energy》 SCIE EI CAS CSCD 2024年第5期105-113,共9页
Porous aromatic framework 1(PAF-1)is an extremely representative nanoporous organic framework owing to its high stability and exceptionally high surface area.Currently,the synthesis of PAF-1 is catalyzed by the Ni(COD... Porous aromatic framework 1(PAF-1)is an extremely representative nanoporous organic framework owing to its high stability and exceptionally high surface area.Currently,the synthesis of PAF-1 is catalyzed by the Ni(COD)2/COD/bpy system,suffering from great instability and high cost.Herein,we developed an in situ reduction of the Ni(II)catalytic system to synthesize PAF-1 in low cost and high yield.The active Ni(0)species produced from the NiCl_(2)/bpy/NaI/Mg catalyst system can effectively catalyze homocoupling of tetrakis(4-bromophenyl)methane at the room temperature to form PAF-1 with high Brunauer-Emmett-Teller(BET)-specific surface area up to 4948 m^(2) g^(−1)(Langmuir surface area,6785 m2 g−1).The possible halogen exchange and dehalogenation coupling mechanisms for this new catalytic process in PAF's synthesis are discussed in detail.The efficiency and universality of this innovative catalyst system have also been demonstrated in other PAFs'synthesis.This work provides a cheap,facile,and efficient method for scalable synthesis of PAFs and explores their application for high-pressure storage of Xe and Kr. 展开更多
关键词 adsorption carbon material nickel catalysis porous aromatic framework porous organic polymer
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Identification of origin of insulating polymer maneuvered photoredox catalysis
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作者 Qiao-Ling Mo Rui Xiong +5 位作者 Jun-Hao Dong Bai-Sheng Sa Jing-Ying Zheng Qing Chen yue wu Fang-Xing Xiao 《Chinese Journal of Catalysis》 SCIE CAS CSCD 2024年第8期109-123,共15页
Solid non-conjugated polymers have long been regarded as insulators due to deficiency of delocalizedπelectrons along the molecular chain framework.Up to date,origin of insulating polymer regulated charge transfer has... Solid non-conjugated polymers have long been regarded as insulators due to deficiency of delocalizedπelectrons along the molecular chain framework.Up to date,origin of insulating polymer regulated charge transfer has not yet been uncovered.In this work,we unleash the root origin of charge transport capability of insulating polymer in photocatalysis.We ascertain that insulating polymer plays crucial roles in fine tuning of electronic structure of transition metal chalcogenides(TMCs),which mainly include altering surface electron density of TMCs for accelerating charge transport kinetics,triggering the generation of defect over TMCs for prolonging carrier lifetime,and acting as hole-trapping mediator for retarding charge recombination.These synergistic roles contribute to the charge transfer of insulating polymer.Our work opens a new vista of utilizing solid insulating polymers for maneuvering charge transfer toward solar energy conversion. 展开更多
关键词 Insulating polymer Charge transfer Photoredox catalysis POLYELECTROLYTE SELF-ASSEMBLY
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Fine-mapping of a candidate gene for web blotch resistance in Arachis hypogaea L.
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作者 Xiaohui wu Mengyuan Zhang +11 位作者 Zheng Zheng Ziqi Sun Feiyan Qi Hua Liu Juan Wang Mengmeng Wang Ruifang Zhao yue wu Xiao Wang Hongfei Liu Wenzhao Dong Xinyou Zhang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第5期1494-1506,共13页
Peanut(Arachis hypogaea L.)is a globally important oil crop.Web blotch is one of the most important foliar diseases affecting peanut,which results in serious yield losses worldwide.Breeding web blotch-resistant peanut... Peanut(Arachis hypogaea L.)is a globally important oil crop.Web blotch is one of the most important foliar diseases affecting peanut,which results in serious yield losses worldwide.Breeding web blotch-resistant peanut varieties is the most effective and economically viable method for minimizing yield losses due to web blotch.In the current study,a bulked segregant analysis with next-generation sequencing was used to analyze an F2:3 segregating population and identify candidate loci related to web blotch resistance.Based on the fine-mapping of the candidate genomic interval using kompetitive allele-specific PCR(KASP)markers,we identified a novel web blotch resistance-related locus spanning approximately 169 kb on chromosome 16.This region included four annotated genes,of which only Arahy.35VVQ3 had a non-synonymous single nucleotide polymorphism in the coding region between the two parents.Two markers(Chr.16.12872635 and Chr.16.12966357)linked to this gene were shown to be co-segregated with the resistance of peanut web blotch by 72 randomly selected recombinant inbred lines(RIL),which could be used in marker-assisted breeding of resistant peanut varieties. 展开更多
关键词 peanut web blotch bulked segregant analysis KAsP markers resistant gene
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Investigation on the Novel High-performance Copper/Graphene Composite Conductor for High Power Density Motor
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作者 Jiaxiao Wang Tingting Zuo +10 位作者 Jiangli Xue Yadong Ru yue wu Zhuang Xu Yongsheng Liu Zhaoshun Gao Puqi Ning Tao Fan Xuhui Wen Li Han Liye Xiao 《CES Transactions on Electrical Machines and Systems》 EI CSCD 2024年第1期80-85,共6页
High-performance Cu/Graphene composite wire synergistically strengthened by nano Cr_(3)C_(2) phase was directly synthesized via hot press sintering followed by severe cold plastic deformation, using liquid paraffin an... High-performance Cu/Graphene composite wire synergistically strengthened by nano Cr_(3)C_(2) phase was directly synthesized via hot press sintering followed by severe cold plastic deformation, using liquid paraffin and CuCr alloy powder as the raw materials. Since graphene is in situ formed under the catalysis of copper powder during the sintering process, the problem that graphene is easy to agglomerate and difficult to disperse uniformly in the copper matrix has been solved. The nano Cr_(3)C_(2)-particles nailed at the interface favor to improve the interface bonding. The Cu/Graphene composite possesses high electrical conductivity, hardness, and plasticity. The composite wire exhibits high electrical conductivity of 96.93% IACS, great tensile strength of 488MPa, and excellent resistance to softening. Even after annealing at 400℃ for 1 h, the tensile strength can still reach 268 MPa with a conductivity of about 99.14% IACS.The wire's temperature coefficient of resistance(TCR) is largely reduced to 0.0035/℃ due to the complex structure,which leads the wire to present low resistivity at higher temperatures. Such Cu/Graphene composite wire with excellent comprehensive performance has a good application prospect in high-power density motors. 展开更多
关键词 Cu/Graphene composite Mechanical properties Electrical property Microstructure Temperature coefficient of resistance
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Refractory autoimmune hemolytic anemia in a patient with systemic lupus erythematosus and ulcerative colitis:A case report
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作者 Dai-Xing Chen yue wu +1 位作者 Sui-Feng Zhang Xiao-Jun Yang 《World Journal of Clinical Cases》 SCIE 2024年第13期2286-2292,共7页
BACKGROUND Ulcerative colitis(UC)and systemic lupus erythematosus(SLE)are both systemic immunoreactive diseases,and their pathogenesis depends on the interaction between genes and environmental factors.There are no re... BACKGROUND Ulcerative colitis(UC)and systemic lupus erythematosus(SLE)are both systemic immunoreactive diseases,and their pathogenesis depends on the interaction between genes and environmental factors.There are no reports of UC with SLE in China,but six cases of SLE with UC have been reported in China.The combination of these two diseases has distinct effects on the pathogenesis of both diseases.CASE SUMMARY A female patient(30 years old)came to our hospital due to dull umbilical pain,diarrhea and mucous bloody stool in August 2018 and was diagnosed with UC.The symptoms were relieved after oral administration of mesalazine(1 g po tid)or folic acid(5 mg po qd),and the patient were fed a control diet.On June 24,2019,the patient was admitted for treatment due to anemia and tinnitus.During hospitalization,the patient had repeated low-grade fever and a progressively decreased Hb level.Blood tests revealed positive antinuclear antibody test,positive anti-dsDNA antibody,0.24 g/L C3(0.9-1.8 g/L),0.04 g/L C4(0.1-0.4 g/L),32.37 g/L immunoglobulin(8-17 g/L),and 31568.1 mg/24 h total 24-h urine protein(0-150 mg/24 h).The patient was diagnosed with SLE involving the joints,kidneys and blood system.Previously reported cases of SLE were retrieved from PubMed to characterize clinicopathological features and identify prognostic factors for SLE.CONCLUSION The patient was discharged in remission after a series of treatments,such as intravenous methylprednisolone sodium succinate,intravenous human immunoglobulin,cyclophosphamide injection,and plasma exchange.After discharge,the patient took oral prednisone acetate tablets,cyclosporine capsules,hydroxychloroquine sulfate tablets and other treatments for symptoms and was followed up regularly for 1 month,after which the patient's condition continued to improve and stabilize. 展开更多
关键词 Plasma exchange Autoimmune hemolytic anemia Systemic lupus erythematosus Ulcerative colitis Case report
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Effects of a periodic intermittent theta burst stimulation in Alzheimer's disease
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作者 Xingqi wu Yibing Yan +12 位作者 Panpan Hu Lu Wang yue wu Pan wu Zhi Geng Guixian Xiao Shanshan Zhou Gongjun Ji Bensheng Qiu Ling Wei Yanghua Tian Hesheng Liu Kai Wang 《General Psychiatry》 CSCD 2024年第1期53-63,共11页
Background Previous studies havedemonstrated that excitatory repetitive transcranial magnetic stimulation(rTMS)can improve the cognitive function of patients with Alzheimer's disease(AD).Intermittent theta burst s... Background Previous studies havedemonstrated that excitatory repetitive transcranial magnetic stimulation(rTMS)can improve the cognitive function of patients with Alzheimer's disease(AD).Intermittent theta burst stimulation(iTBS)is a novel excitatory rTMS protocol for brain activity stimulation with the ability to induce long-term potentiation-like plasticity and represents a promising treatment for AD.However,the long-term effects of iTBS on cognitive decline and brain structure in patients with AD areunknown.Aims We aimed to explore whether repeating accelerated iTBS every three months could slow down the cognitive decline in patients with AD.Methods In this randomised,assessor-blinded,controlled trial,iTBS was administered to the left dorsolateral prefrontal cortex(DLPFC)of 42 patients with AD for 14days every 13weeks.Measurements included the Montreal Cognitive Assessment(MoCA),a comprehensive neuropsychological battery,and the grey matter volume(GMV)of the hippocampus.Patients were evaluated at baseline and after follow-up.The longitudinal pipeline of the Computational Anatomy Toolbox for SPM was used to detect significant treatment-related changes over time.Results The iTBS group maintained MoCA scores relative to the control group(t=3.26,p=0.013)and reduced hippocampal atrophy,which was significantly correlated with global degeneration scale changes.The baseline Mini-Mental State Examination(MMSE)score,apolipoprotein E genotype and Clinical Dementia Rating were indicative of MoCA scores at follow-up.Moreover,the GMV of the left(t=0.08,p=0.996)and right(t=0.19,p=0.977)hippocampus were maintained in the active group but significantly declined in the control group(left:t=4.13,p<0.001;right:t=5.31,p<0.001).GMV change in the left(r=0.35,p=0.023)and right(r=0.36,p=0.021)hippocampus across the intervention positively correlated with MoCA changes;left hippocampal GMV change was negatively correlated with global degeneration scale(r=-0.32,p=0.041)changes.Conclusions DLPFC-iTBS maybe a feasible and easy-to-implement non-pharmacological intervention to slow down the progressive decline of overall cognition and quality of life in patients with AD,providing a new AD treatment option.Trial registration number NCT04754152. 展开更多
关键词 STIMULATION ALZHEIMER maintained
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超声提取-高效液相色谱法测定化妆品中5种苯并三唑类紫外线吸收剂 被引量:3
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作者 王磊 吴越 田冬 《日用化学工业(中英文)》 CAS 北大核心 2023年第1期109-114,共6页
建立了一种利用高效液相色谱同时测定化妆品中甲酚曲唑(UV-P)、奥克三唑(UV-329)、布美三唑(UV-326)、甲酚曲唑三硅氧烷(DTTSO)、亚甲基双-苯并三唑基四甲基丁基酚(UV-360)的方法。其中,水状化妆品经甲醇/四氢呋喃溶解、超声提取、微孔... 建立了一种利用高效液相色谱同时测定化妆品中甲酚曲唑(UV-P)、奥克三唑(UV-329)、布美三唑(UV-326)、甲酚曲唑三硅氧烷(DTTSO)、亚甲基双-苯并三唑基四甲基丁基酚(UV-360)的方法。其中,水状化妆品经甲醇/四氢呋喃溶解、超声提取、微孔滤膜过滤后进样;乳液状、霜状化妆品经甲醇/四氢呋喃溶解、涡旋振荡、超声提取、微孔滤膜过滤后进样。使用ZORBAX SC-C18色谱柱(250 mm×4.6 mm,5μm),柱温23℃,以0.1%的甲酸水溶液为A相、甲醇为B相、四氢呋喃为C相进行洗脱,流速1.0 mL/min,检测波长340 nm,进样量5μL。结果表明,5种紫外线吸收剂在11~176 mg/L的质量浓度范围内线性关系良好(R2≧0.9994),检测限分别为6.72,11.94,13.80,18.47和23.49μg/L,相对标准偏差小于1.7%(n=6),加标平均回收率达到93.7%~104.5%。该方法能满足化妆品中5种苯并三唑类紫外线吸收剂的测定。 展开更多
关键词 超声提取 高效液相色谱 化妆品 苯并三唑 防晒剂 紫外线吸收剂
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"Three-in-One" Multi-Scale Structural Design of Carbon Fiber-Based Composites for Personal Electromagnetic Protection and Thermal Management 被引量:6
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作者 Ming Zhou Shujuan Tan +3 位作者 Jingwen Wang yue wu Leilei Liang Guangbin Ji 《Nano-Micro Letters》 SCIE EI CAS CSCD 2023年第10期317-333,共17页
Wearable devices with efficient thermal management and electromagnetic interference(EMI) shielding are highly desirable for improving human comfort and safety. Herein, a multifunctional wearable carbon fibers(CF) @ po... Wearable devices with efficient thermal management and electromagnetic interference(EMI) shielding are highly desirable for improving human comfort and safety. Herein, a multifunctional wearable carbon fibers(CF) @ polyaniline(PANI)/silver nanowires(Ag NWs) composites with a “branch-trunk” interlocked micro/nanostructure were achieved through "three-in-one" multi-scale design. The reasonable assembly of the three kinds of one-dimensional(1D) materials can fully exert their excellent properties i.e., the superior flexibility of CF, the robustness of PANI, and the splendid conductivity of Ag NWs. Consequently, the constructed flexible composite demonstrates enhanced mechanical properties with a tensile stress of 1.2 MPa, which was almost 6 times that of the original material. This is mainly attributed to the fact that the PNAI(branch) was firmly attached to the CF(trunk) through polydopamine(PDA), forming a robust interlocked structure. Meanwhile, the composite possesses excellent thermal insulation and heat preservation capacity owing to the synergistically low thermal conductivity and emissivity. More importantly, the conductive path of the composite established by the three 1D materials greatly improved its EMI shielding property and Joule heating performance at low applied voltage. This work paves the way for rational utilization of the intrinsic properties of 1D materials, as well as provides a promising strategy for designing wearable electromagnetic protection and thermal energy management devices. 展开更多
关键词 Electromagnetic shielding Multi-scale design One-dimensional materials Carbon fiber Thermal management
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气腔扩散阳性的肺腺癌临床病理学特征分析
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作者 范蕾 秦积龙 +3 位作者 林晓东 吴悦 何珍珍 何萍 《中国肺癌杂志》 CAS CSCD 北大核心 2023年第9期650-658,共9页
背景与目的气腔扩散(spread through air spaces,STAS)作为一种新发现的肺癌侵袭方式,其生物学特点及分子特征尚存在争议。本研究旨在探讨STAS与肺浸润性腺癌临床病理学特征及基因改变的关系。方法选取广州医科大学附属第一医院2019年7... 背景与目的气腔扩散(spread through air spaces,STAS)作为一种新发现的肺癌侵袭方式,其生物学特点及分子特征尚存在争议。本研究旨在探讨STAS与肺浸润性腺癌临床病理学特征及基因改变的关系。方法选取广州医科大学附属第一医院2019年7月至2021年3月确诊的肺非黏液性浸润性腺癌手术切除标本694例,分析STAS与临床病理因素之间的关系。应用免疫组织化学方法检测间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)蛋白表达;应用扩增阻滞突变系统-聚合酶链反应(amplification refractory mutation system-polymerase chain reaction,ARMS-PCR)技术检测表皮生长因子受体(epidermal growth factor receptor,EGFR)基因突变;应用反转录-PCR(reverse transcription-PCR,RT-PCR)技术检测肉瘤致癌因子受体(ROS proto-oncogene 1-receptor,ROS1)基因融合。结果STAS阳性病例共344例,STAS阴性病例共350例。STAS阳性与肿瘤最大径(P<0.001)、胸膜侵犯(P<0.001)、脉管侵犯(P<0.001)、神经束侵犯(P=0.013)、淋巴结转移(P<0.001)、临床分期(P<0.001)及组织学分型(P<0.001)相关;STAS与ALK蛋白表达(P<0.001)相关。多因素分析表明,STAS阳性与胸膜侵犯(P=0.001)、脉管侵犯(P<0.001)、淋巴结转移(P=0.005)及ALK蛋白表达(P=0.032)相关。结论STAS阳性与肺腺癌高侵袭性生物学行为有关,提示不良预后。 展开更多
关键词 肺肿瘤 肺腺癌 气腔扩散
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Tumor neoantigens: Novel strategies for application of cancer immunotherapy 被引量:3
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作者 HANYANG GUAN yue wu +10 位作者 LU LI YABING YANG SHENGHUI QIU ZHAN ZHAO XIAODONG CHU JIASHUAI HE ZUYANG CHEN YIRAN ZHANG HUI DING JINGHUA PAN YUNLONG PAN 《Oncology Research》 SCIE 2023年第4期437-448,共12页
Neoantigen-targeted immunotherapy is a rapidly advancing field that holds great promise for treating cancer.The recognition of antigens by immune cells is a crucial step in tumor-specific killing,and neoantigens gener... Neoantigen-targeted immunotherapy is a rapidly advancing field that holds great promise for treating cancer.The recognition of antigens by immune cells is a crucial step in tumor-specific killing,and neoantigens generated by mutations in cancer cells possess high immunogenicity and are selectively expressed in tumor cells,making them an attractive therapeutic target.Currently,neoantigens find utility in various domains,primarily in the realm of neoantigen vaccines such as DC vaccines,nucleic acid vaccines,and synthetic long peptide vaccines.Additionally,they hold promise in adoptive cell therapy,encompassing tumor-infiltrating cells,T cell receptors,and chimeric antigen receptors which are expressed by genetically modified T cells.In this review,we summarized recent progress in the clinical use of tumor vaccines and adoptive cell therapy targeting neoantigens,discussed the potential of neoantigen burden as an immune checkpoint in clinical settings.With the aid of state-of-the-art sequencing and bioinformatics technologies,together with significant advancements in artificial intelligence,we anticipated that neoantigens will be fully exploited for personalized tumor immunotherapy,from screening to clinical application. 展开更多
关键词 IMMUNOTHERAPY Tumor vaccine Adoptive T cell therapy Chimeric antigen receptor
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Co-Production of High-Grade Dissolving Pulp,Furfural,and Lignin from Eucalyptus via Extremely Low Acid Pretreatment and Pulping Technologies and Catalysis 被引量:1
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作者 Chengxiang Li yue wu +3 位作者 Chunhui Zhang Yao Liu Qixuan Lin Junli Ren 《Journal of Renewable Materials》 SCIE EI 2023年第6期2555-2574,共20页
Hemicellulose and lignin are not reasonably utilized during the dissolved pulp preparation process.This work aimed to propose a process for the co-production of dissolving pulp,furfural,and lignin from eucalyptus.High... Hemicellulose and lignin are not reasonably utilized during the dissolved pulp preparation process.This work aimed to propose a process for the co-production of dissolving pulp,furfural,and lignin from eucalyptus.High-grade dissolving pulp was prepared from eucalyptus using a combination of extremely low acid(ELA)pretreatment,Kraft cooking,and elementary chlorine-free(ECF)bleaching.The obtained pre-hydrolysate was catalytic conversion into furfural in a biphasic system,and lignin during Kraft cooking and ECF was recovered.The process condition was discussed as well as the mass flow direction.The results showed that ELA pretreatment could effectively remove 80.1%hemicellulose.Compared with traditional hydrothermal pretreatment,the ELA pretreatment significantly increased the xylose yield from 5.05 to 14.18 g/L at 170℃ for 2 h,which had practical significance for furfural production.The 82.7%furfural yield and 82.9%furfural selectivity were obtained from xylose-rich pre-hydrolysate using NaCl as a phase modifier in a biphasic system with 4-methyl-2-pentanone(MIBK)as an organic phase by ion exchange resin catalysts at 190℃ for 2 h.Subsequently,the pretreated eucalyptus was subjected to Kraft cooking,and the optimal alkali amount was 14%.Then,the Kraft pulp was bleached using the O-D1-EP-D_(2) sequence,and dissolving pulp was obtained with an ISO brightness of 86.0%,viscosity of 463 mL/g,andα-cellulose content of 95.4%.The Kraft lignin which has a potential application was investigated by 2D-HSQC NMR and 31P NMR.The results showed that the S/G ratio of Kraft lignin was 1.93,and the content of phenolic hydroxyl groups was 2.53 mmol/g.Moreover,based on the above proposed process,30.5 g dissolving pulp,5.5 g furfural,and 21.2 g lignin per 100 g eucalyptus chips(oven dry)were produced.This research will provide new catalysis and pulping technical routes for dissolving pulp,furfural,and Kraft lignin products,which are in great demand in the chemical industry. 展开更多
关键词 EUCALYPTUS extremely low acid pretreatment dissolving pulp FURFURAL kraft lignin
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A Model for Predicting the Erosion Rate Induced by the Use of a Selective Catalytic Reduction Denitrification Technology in Cement Kilns Flue Gas 被引量:1
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作者 Yihua Gao Fuping Qian +5 位作者 Yi Sun yue wu Shenghua wu Jinli Lu Yunlong Han Naijin Huang 《Fluid Dynamics & Materials Processing》 EI 2023年第8期1997-2011,共15页
Selective catalytic reduction(SCR)is a technology by which nitrogen oxides are converted with the aid of a catalyst into diatomic nitrogen and water.It is known that the catalyst can be easily eroded if a cement kiln ... Selective catalytic reduction(SCR)is a technology by which nitrogen oxides are converted with the aid of a catalyst into diatomic nitrogen and water.It is known that the catalyst can be easily eroded if a cement kiln with a high-dust content is considered.To understand this process,numerical simulations have been carried out considering a single catalyst channel in order to study the collision and erosion of fly ash and catalysts at meso scale.Based on a response surface methodology,the effects of five factors on the erosion rate have been studied,namely,the catalyst particle velocity,the particle size,the particle concentration,the incidence angle and the catalyst porosity.The results show that the influence of particle velocity,particle size and particle concentration is statistically significant and the particle size and incidence angle have a significant effect on the erosion rate.A quadratic polynomial prediction model for the erosion rate of honeycomb catalysts in cement kiln SCR reactors is finally proposed to support the future optimization of these systems. 展开更多
关键词 Cement kiln SCR denitrification catalyst erosion numerical simulation
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消费行为与信贷违约——基于自我调节理论的实证分析
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作者 吴越 张颖婕 +2 位作者 陆天 徐云杰 孙毅衡 《经济管理学刊》 2023年第2期97-128,共32页
在金融科技快速发展的今天,信贷风险是金融行业关注的重心。传统研究在分析用户信贷违约行为时,主要集中于用户一些基本的、静态的信息。结合近年来日益普及的数字化支付交易,本文研究了消费行为与信贷违约的关系。本文首先从自我调节... 在金融科技快速发展的今天,信贷风险是金融行业关注的重心。传统研究在分析用户信贷违约行为时,主要集中于用户一些基本的、静态的信息。结合近年来日益普及的数字化支付交易,本文研究了消费行为与信贷违约的关系。本文首先从自我调节理论出发,对品类级消费倾向的价值进行了理论分析。在该理论的指导下,本文重点关注人们在医疗健康和教育方面的消费行为。通过运用问卷调查和计量经济学方法,本文实证验证了品类级消费倾向对信用风险评估的解释价值。值得一提的是,在实证中,本文发现虽然医疗健康和教育方面的消费频率不高,但对于了解借款人的需求、动态监测和评估其信用状况有很强的指示作用。进一步地,本文考虑了未来导向消费倾向对信贷违约的作用机制,分析了未来导向对用户违约的影响。结果表明,重视未来导向相关产品消费的用户其违约的可能性更低。本文为行为理论指导金融风险管控提供了有价值的思路。 展开更多
关键词 信贷违约 自我调节理论 消费倾向 双重差分 未来导向
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Evolutionary Multitask Optimization in Real-World Applications: A Survey 被引量:2
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作者 yue wu Hangqi Ding +5 位作者 Benhua Xiang Jinlong Sheng Wenping Ma Kai Qin Qiguang Miao Maoguo Gong 《Journal of Artificial Intelligence and Technology》 2023年第1期32-38,共7页
Because of its strong ability to solve problems,evolutionary multitask optimization(EMTO)algorithms have been widely studied recently.Evolutionary algorithms have the advantage of fast searching for the optimal soluti... Because of its strong ability to solve problems,evolutionary multitask optimization(EMTO)algorithms have been widely studied recently.Evolutionary algorithms have the advantage of fast searching for the optimal solution,but it is easy to fall into local optimum and difficult to generalize.Combining evolutionary multitask algorithms with evolutionary optimization algorithms can be an effective method for solving these problems.Through the implicit parallelism of tasks themselves and the knowledge transfer between tasks,more promising individual algorithms can be generated in the evolution process,which can jump out of the local optimum.How to better combine the two has also been studied more and more.This paper explores the existing evolutionary multitasking theory and improvement scheme in detail.Then,it summarizes the application of EMTO in different scenarios.Finally,according to the existing research,the future research trends and potential exploration directions are revealed. 展开更多
关键词 evolutionary multitasking evolutionary algorithm OPTIMIZATION
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