Histone deacetylases(HDACs)inhibitors are novel in cancer therapy nowadays.HDAC6-selective inhibitors exert advantageous effects due to higher selectivity and less toxicity.We explored the anti-tumor effect and the mo...Histone deacetylases(HDACs)inhibitors are novel in cancer therapy nowadays.HDAC6-selective inhibitors exert advantageous effects due to higher selectivity and less toxicity.We explored the anti-tumor effect and the molecular mechanism of cay 10603,a potent HDAC6 inhibitor in Burkitt's lymphoma cells.Our study revealed cay 10603 inhibited the proliferation of Burkitt's lymphoma cell lines,and induced caspase-dependent apoptosis.Cayl0603 inhibited the expression of CDKs and cyciins to impede cell cycle progression in both Burkitt's lymphoma cell lines.Cay 10603 also showed the additive effect with vpl 6 notably.Our data presented the promising anti-tumor effect of cay 10603 in the Burkitt's lymphoma therapy.展开更多
Ecological purification in a reservoir is an important strategy to control the level of nutrients in water.The bacterial community of such a reservoir is the main agent for pollutant degradation,which has not been ful...Ecological purification in a reservoir is an important strategy to control the level of nutrients in water.The bacterial community of such a reservoir is the main agent for pollutant degradation,which has not been fully documented.Taking the Jinze Reservoir,a freshwater source for Shanghai,China as the case,its spatial distributions of water and sediment bacteria were determined using 16S rRNA gene-based Illumina MiSeq sequencing,and the environmental parameters were analyzed.The reservoir takes natural river water and functions as an ecological purification system,consisting of three functional zones,i.e.,pretreatment zone,ecological purification zone,and ecological sustaining zone.Results show that the concentrations of both total nitrogen(TN)and total phosphorus(TP)decreased considerably after the ecological treatment,and the concentration of dissolved oxygen(DO)in the ecological purification zone was boosted from that before pretreatment.In addition,patterns of bacterial communities in both water and sediment were similar and consisted of mainly Proteobacteria,Actinobacteria,and Bacteroidetes.However,difference in water bacterial composition was distinct in each functional zone,whereas the bacterial communities in sediment changed only slightly among sediment samples.Network analysis revealed nonrandom co-occurrence patterns of bacterial community composition in water and sediment,and Pseudomonas,unclassified Comamonadaceae,Variovorax,and Dechloromonas were the key taxa in the co-occurrence network.The bacterial taxa from the same module of the network had strong ecological connections,participated in C-cycles,and shared common trophic properties.PICRUSt analysis showed that bacteria were involved potentially in various essential processes;and the abundance of predicted xenobiotic biodegradation genes showed a decreasing trend in water samples from the inlet to the outlet of the reservoir.These results improve our current knowledge of the spatial distribution of bacteria in water and sediment in ecological purification reservoirs.展开更多
Chinese migrant workers are very exposed to the shocks caused by the COVID-19 pandemic.Falling remittances adversely affect their families who rely on remittance incomes.The impacts of COVID-19 on migrants and remitta...Chinese migrant workers are very exposed to the shocks caused by the COVID-19 pandemic.Falling remittances adversely affect their families who rely on remittance incomes.The impacts of COVID-19 on migrants and remittance-receiving households are assessed using a nationally representative household dataset and a microsimulation model.We found about 70 percent of migrant workers lost part of their wage income during the pandemic lockdown period and rural migrants working in small and medium enterprises were affected the most.This led to about 50 percent of remittance-receiving households being affected adversely by falling remittances,and the average decline in such income was more than 45 percent.Nearly 13 percent of pre-pandemic nonpoor remittance-receiving households could fall into poverty,raising the poverty rate among remittancereceiving households by 4 percentage points.Many households that were poor prior to the pandemic became more impoverished.The results indicate that social protection programs targeting vulnerable migrants and their families at home are important.展开更多
文摘Histone deacetylases(HDACs)inhibitors are novel in cancer therapy nowadays.HDAC6-selective inhibitors exert advantageous effects due to higher selectivity and less toxicity.We explored the anti-tumor effect and the molecular mechanism of cay 10603,a potent HDAC6 inhibitor in Burkitt's lymphoma cells.Our study revealed cay 10603 inhibited the proliferation of Burkitt's lymphoma cell lines,and induced caspase-dependent apoptosis.Cayl0603 inhibited the expression of CDKs and cyciins to impede cell cycle progression in both Burkitt's lymphoma cell lines.Cay 10603 also showed the additive effect with vpl 6 notably.Our data presented the promising anti-tumor effect of cay 10603 in the Burkitt's lymphoma therapy.
基金Supported by the Key Program in the Youth Elite Support Plan in Universities of Anhui Province(No.gxyqZD2020046)the Key Program in the Key University Science Research Project of Anhui Province(No.KJ2020A0716)the Key Research and Development Program of Anhui Province(No.202004i07020010)。
文摘Ecological purification in a reservoir is an important strategy to control the level of nutrients in water.The bacterial community of such a reservoir is the main agent for pollutant degradation,which has not been fully documented.Taking the Jinze Reservoir,a freshwater source for Shanghai,China as the case,its spatial distributions of water and sediment bacteria were determined using 16S rRNA gene-based Illumina MiSeq sequencing,and the environmental parameters were analyzed.The reservoir takes natural river water and functions as an ecological purification system,consisting of three functional zones,i.e.,pretreatment zone,ecological purification zone,and ecological sustaining zone.Results show that the concentrations of both total nitrogen(TN)and total phosphorus(TP)decreased considerably after the ecological treatment,and the concentration of dissolved oxygen(DO)in the ecological purification zone was boosted from that before pretreatment.In addition,patterns of bacterial communities in both water and sediment were similar and consisted of mainly Proteobacteria,Actinobacteria,and Bacteroidetes.However,difference in water bacterial composition was distinct in each functional zone,whereas the bacterial communities in sediment changed only slightly among sediment samples.Network analysis revealed nonrandom co-occurrence patterns of bacterial community composition in water and sediment,and Pseudomonas,unclassified Comamonadaceae,Variovorax,and Dechloromonas were the key taxa in the co-occurrence network.The bacterial taxa from the same module of the network had strong ecological connections,participated in C-cycles,and shared common trophic properties.PICRUSt analysis showed that bacteria were involved potentially in various essential processes;and the abundance of predicted xenobiotic biodegradation genes showed a decreasing trend in water samples from the inlet to the outlet of the reservoir.These results improve our current knowledge of the spatial distribution of bacteria in water and sediment in ecological purification reservoirs.
基金supports from the National Natural Science Foundation of China(No.71761147004)the Agricultural Science and Technology Innovation Program(No.2021-RY-01)+1 种基金Zhejiang University-IFPRI Center for International Development Studiesthe Consultative Group on International Agricultural Research(CGIAR)Program on Policies,Institutions,and Markets(PIM)led by IFPRI.
文摘Chinese migrant workers are very exposed to the shocks caused by the COVID-19 pandemic.Falling remittances adversely affect their families who rely on remittance incomes.The impacts of COVID-19 on migrants and remittance-receiving households are assessed using a nationally representative household dataset and a microsimulation model.We found about 70 percent of migrant workers lost part of their wage income during the pandemic lockdown period and rural migrants working in small and medium enterprises were affected the most.This led to about 50 percent of remittance-receiving households being affected adversely by falling remittances,and the average decline in such income was more than 45 percent.Nearly 13 percent of pre-pandemic nonpoor remittance-receiving households could fall into poverty,raising the poverty rate among remittancereceiving households by 4 percentage points.Many households that were poor prior to the pandemic became more impoverished.The results indicate that social protection programs targeting vulnerable migrants and their families at home are important.
