Objective:To explore the value of fluid dynamic parameters and inflammatory factors in the prediction of early atherosclerosis in type 2 diabetes mellitus.Methods:A total of 126 patients with type 2 diabetes mellitus ...Objective:To explore the value of fluid dynamic parameters and inflammatory factors in the prediction of early atherosclerosis in type 2 diabetes mellitus.Methods:A total of 126 patients with type 2 diabetes mellitus who were admitted to our hospital from March 2015 to July 2016 were selected as study subjects and divided into non atherosclerotic group (61 cases) and atherosclerosis group (65 cases)according to carotid artery IMT. At the same time, 60 healthy persons were selected as the control group. The fluid dynamics indexes (PSV, EDV and MV) and serum inflammatory factors (MCP-1, TNF-α and hs-CRP) were detected in the three groups.Results: There were no significant differences in PSV, EDV and MV between left and right carotid arteries in non-atherosclerotic group and control group. PSV, EDV and MV of left and right carotid artery were significantly lower in atherosclerosis group than those in control group. The carotid artery PSV, EDV and MV of left and right in atherosclerosis group were also significantly lower than those of non-atherosclerosis group. The MCP-1, TNF-α and hs-CRP levels in the non-atherosclerosis group were respectively (417.10±78.54), (85.72±9.97) and (3.73±0.61), significantly higher than those in the control group. The MCP-1, TNF-αand hs-CRP levels in atherosclerosis group were respectively (532.95±97.48), (123.56±12.85) and (5.39±0.74) , significantly higher than those in the control group and non-atherosclerosis group.Conclusion:Hydrodynamic parameters and serum inflammatory factors can be used as diagnostic criteria for carotid atherosclerosis in type 2 diabetic patients, and provide guidance for the early diagnosis of carotid atherosclerosis in patients with type 2 diabetes mellitus.展开更多
Porous carbon material facilitates the reaction SO2+O2+H2O!H2SO4 in coal-burned flue gas for sulfur resources recovery at mild conditions.It draws a long-term mystery on its heterogeneous catalysis due to the complica...Porous carbon material facilitates the reaction SO2+O2+H2O!H2SO4 in coal-burned flue gas for sulfur resources recovery at mild conditions.It draws a long-term mystery on its heterogeneous catalysis due to the complicated synergic effect between its microstructure and chemical components.To decouple the effects of geometric structure from chemical components,classical molecular dynamics method was used to investigate the static and dynamic characteristics of the reactants(H2O,SO2 and O2)in the confined space truncated by double-layer graphene(DLG).Strong adsorption of SO2 and O2 by the DLG was observed,which results in the filling of the solute molecules into the interior of the DLG and the depletion of H2O.This effect mainly results from the different affinity of the DLG to the species and can be tuned by the separation of the two graphene layers.Such dimension dependence of the static and dynamic properties like distribution profile,molecular cluster,hydrogen bond and diffusion coefficient were also studied.The conclusions drawn in this work could be helpful to the further understanding of the underlying reaction mechanism of desulfurization process in porous carbon materials and other applications of carbon-based catalysts.展开更多
文摘Objective:To explore the value of fluid dynamic parameters and inflammatory factors in the prediction of early atherosclerosis in type 2 diabetes mellitus.Methods:A total of 126 patients with type 2 diabetes mellitus who were admitted to our hospital from March 2015 to July 2016 were selected as study subjects and divided into non atherosclerotic group (61 cases) and atherosclerosis group (65 cases)according to carotid artery IMT. At the same time, 60 healthy persons were selected as the control group. The fluid dynamics indexes (PSV, EDV and MV) and serum inflammatory factors (MCP-1, TNF-α and hs-CRP) were detected in the three groups.Results: There were no significant differences in PSV, EDV and MV between left and right carotid arteries in non-atherosclerotic group and control group. PSV, EDV and MV of left and right carotid artery were significantly lower in atherosclerosis group than those in control group. The carotid artery PSV, EDV and MV of left and right in atherosclerosis group were also significantly lower than those of non-atherosclerosis group. The MCP-1, TNF-α and hs-CRP levels in the non-atherosclerosis group were respectively (417.10±78.54), (85.72±9.97) and (3.73±0.61), significantly higher than those in the control group. The MCP-1, TNF-αand hs-CRP levels in atherosclerosis group were respectively (532.95±97.48), (123.56±12.85) and (5.39±0.74) , significantly higher than those in the control group and non-atherosclerosis group.Conclusion:Hydrodynamic parameters and serum inflammatory factors can be used as diagnostic criteria for carotid atherosclerosis in type 2 diabetic patients, and provide guidance for the early diagnosis of carotid atherosclerosis in patients with type 2 diabetes mellitus.
基金supported by the National Natural Science Foundation of China(Grant No.51508356)the Scientific Research Foundation of the Science and Technology Department of Sichuan Province,China(No.2017GZ0376).
文摘Porous carbon material facilitates the reaction SO2+O2+H2O!H2SO4 in coal-burned flue gas for sulfur resources recovery at mild conditions.It draws a long-term mystery on its heterogeneous catalysis due to the complicated synergic effect between its microstructure and chemical components.To decouple the effects of geometric structure from chemical components,classical molecular dynamics method was used to investigate the static and dynamic characteristics of the reactants(H2O,SO2 and O2)in the confined space truncated by double-layer graphene(DLG).Strong adsorption of SO2 and O2 by the DLG was observed,which results in the filling of the solute molecules into the interior of the DLG and the depletion of H2O.This effect mainly results from the different affinity of the DLG to the species and can be tuned by the separation of the two graphene layers.Such dimension dependence of the static and dynamic properties like distribution profile,molecular cluster,hydrogen bond and diffusion coefficient were also studied.The conclusions drawn in this work could be helpful to the further understanding of the underlying reaction mechanism of desulfurization process in porous carbon materials and other applications of carbon-based catalysts.
