Vitamins are vital to sustain normal physiological function, metabolism, and growth for all living organisms. Being an integral component of coenzyme, vitamins can affect the catalytic activities of many enzymes and t...Vitamins are vital to sustain normal physiological function, metabolism, and growth for all living organisms. Being an integral component of coenzyme, vitamins can affect the catalytic activities of many enzymes and the expression of drug transporters. Genetic variations in metabolism and/or transporter genes of drugs can influence the exposure of the human body to drugs and/or their active metabolites, thus contributing to the variations in drug responses and toxicities.Nonetheless, pharmacogenomics studies on nutrients have been rarely summarized. In this article,we reviewed recent progress on vitamin pharmacogenomics, for a better understanding on the influence of vitamin-related gene polymorphisms on inter-individual differences in diseases and drug efficacy and safety.展开更多
基金supported by grants from the National Key Research and Development Program (Grant No. 2016YFC0905000)National High-tech R&D Program of China (863 Program+2 种基金 Grant No. 2012AA02A518)National Natural Scientific Foundation of China (Grant Nos. 81522048, 81573511, and 81273595)the Innovationdriven Project of Central South University, China (Grant No. 2016CX024)
文摘Vitamins are vital to sustain normal physiological function, metabolism, and growth for all living organisms. Being an integral component of coenzyme, vitamins can affect the catalytic activities of many enzymes and the expression of drug transporters. Genetic variations in metabolism and/or transporter genes of drugs can influence the exposure of the human body to drugs and/or their active metabolites, thus contributing to the variations in drug responses and toxicities.Nonetheless, pharmacogenomics studies on nutrients have been rarely summarized. In this article,we reviewed recent progress on vitamin pharmacogenomics, for a better understanding on the influence of vitamin-related gene polymorphisms on inter-individual differences in diseases and drug efficacy and safety.
