To investigate the chemical constituents of the stems ofAquilaria sinensis （Lour.） Gilg, the separation and purification were performed by solvent extraction, repeated chromatography on silica gel, Sephadex LH-20 an...To investigate the chemical constituents of the stems ofAquilaria sinensis （Lour.） Gilg, the separation and purification were performed by solvent extraction, repeated chromatography on silica gel, Sephadex LH-20 and prep-HPLC. The structures were determined by spectrum analysis. Thirteen known compounds were isolated and their structures were identified as justicidin A （1）, justidin F （2）, ciwujiatone （3）, （＋） syringaresinol （4）, syringaresinol-4,4＇-di-O-13-D-glucopyranoside （5）, syringaresinol-4＂O-β-D- glucopyranoside （6）, curuilignan D （7）, syringin （8）, koaburaside （9）, 3,4,5-trimethoxyphenyl-l-O-β-D-glucopyranoside （10）, 3,4,5-trimethoxyphenyl-l-O-13-D-apiofuranosyl-（1 ＂→6＇） glucopyranoside （11）, 7-ketositosterol （12）, 7-oxo-5,6-dihydrostigmasterol （13）. All the compounds described above were isolated from genus Aquilaria for the first time.展开更多
基金The Special Program for New Drug Innovation of the Ministry of Science and Technology,China(Grant No. 2009ZX311-004,2009ZX0308-004)
文摘To investigate the chemical constituents of the stems ofAquilaria sinensis （Lour.） Gilg, the separation and purification were performed by solvent extraction, repeated chromatography on silica gel, Sephadex LH-20 and prep-HPLC. The structures were determined by spectrum analysis. Thirteen known compounds were isolated and their structures were identified as justicidin A （1）, justidin F （2）, ciwujiatone （3）, （＋） syringaresinol （4）, syringaresinol-4,4＇-di-O-13-D-glucopyranoside （5）, syringaresinol-4＂O-β-D- glucopyranoside （6）, curuilignan D （7）, syringin （8）, koaburaside （9）, 3,4,5-trimethoxyphenyl-l-O-β-D-glucopyranoside （10）, 3,4,5-trimethoxyphenyl-l-O-13-D-apiofuranosyl-（1 ＂→6＇） glucopyranoside （11）, 7-ketositosterol （12）, 7-oxo-5,6-dihydrostigmasterol （13）. All the compounds described above were isolated from genus Aquilaria for the first time.
