Altered metabolism is a hallmark of cancer,and the reprogramming of energy metabolism has historically been considered a general phenomenon of tumors.It is well recognized that long noncoding RNAs(lncRNAs)regulate ene...Altered metabolism is a hallmark of cancer,and the reprogramming of energy metabolism has historically been considered a general phenomenon of tumors.It is well recognized that long noncoding RNAs(lncRNAs)regulate energy metabolism in cancer.However,lncRNA-mediated posttranslational modifications and metabolic reprogramming are unclear at present.In this review,we summarized the current understanding of the interactions between the alterations in cancer-associated energy metabolism and the lncRNA-mediated posttranslational modifications of metabolic enzymes,transcription factors,and other proteins involved in metabolic pathways.In addition,we discuss the mechanisms through which these interactions contribute to tumor initiation and progression,and the key roles and clinical significance of functional lncRNAs.We believe that an in-depth understanding of lncRNA-mediated cancer metabolic reprogramming can help to identify cellular vulnerabilities that can be exploited for cancer diagnosis and therapy.展开更多
Metabolic enzymes have an indispensable role in metabolic reprogramming,and their aberrant expression or activity has been associated with chemosensitivity.Hence,targeting metabolic enzymes remains an attractive appro...Metabolic enzymes have an indispensable role in metabolic reprogramming,and their aberrant expression or activity has been associated with chemosensitivity.Hence,targeting metabolic enzymes remains an attractive approach for treating tumors.展开更多
基金This study was supported by the National Key R&D Program of China(2018YFC1313304 and 2018YFC1313300)the National Natural Science Foundation of China(82073112,82022052 and 81871951).
文摘Altered metabolism is a hallmark of cancer,and the reprogramming of energy metabolism has historically been considered a general phenomenon of tumors.It is well recognized that long noncoding RNAs(lncRNAs)regulate energy metabolism in cancer.However,lncRNA-mediated posttranslational modifications and metabolic reprogramming are unclear at present.In this review,we summarized the current understanding of the interactions between the alterations in cancer-associated energy metabolism and the lncRNA-mediated posttranslational modifications of metabolic enzymes,transcription factors,and other proteins involved in metabolic pathways.In addition,we discuss the mechanisms through which these interactions contribute to tumor initiation and progression,and the key roles and clinical significance of functional lncRNAs.We believe that an in-depth understanding of lncRNA-mediated cancer metabolic reprogramming can help to identify cellular vulnerabilities that can be exploited for cancer diagnosis and therapy.
基金This research was supported by the National Natural Science Foundation of China(82022052,82173128,81930065,82073377,81772587)Natural Science Foundation of Guangdong Province(2018B030306049,2021A1515012439)Science and Technology Program of Guangdong(2019B020227002)+1 种基金Science and Technology Program of Guangzhou(201904020046)CAMS Innovation Fund for Medical Sciences(CIFMS)(2019-I2M-5-036).
文摘Metabolic enzymes have an indispensable role in metabolic reprogramming,and their aberrant expression or activity has been associated with chemosensitivity.Hence,targeting metabolic enzymes remains an attractive approach for treating tumors.
