Study on prescription medication mode and mechanism of traditional Chinese medicine in the treatment of noncritical COVID-19 based on data mining

Background:As of 2023,coronavirus disease 2019(COVID-19)is still spreading globally.Therefore,we aim to integrate non-critical COVID-19 high-frequency and high-targeting Chinese medicines to provide a reference for clinical prescriptions to improve COVID-19-related symptoms.Materials and methods:The information on non-critical COVID-19 high-frequency Chinese medicines in the diagnosis and treatment of COVID-19 was obtained by the TCM inheritance support platform.Using network pharmacology and molecular docking technology,high-targeting Chinese medicines with good docking activity with COVID-19 receptors angiotensin-converting enzyme-II(ACE2),3CLpro and tyrosine-protein kinase receptor UFO(AXL)were obtained.A new prescription for non-critical COVID-19 was established by integrating high-frequency and high-targeting Chinese medicines.Rats with acute lung injury induced by lipopolysaccharide were used as the experimental model.The histopathological changes in the lungs of rats in each group were observed by hematoxylin-eosin staining.The lung coefficient of rats was measured.The levels of IL-6,TNF-α,and IL-1βin serum were detected by enzyme-linked immunosorbent assay.The mRNA and protein levels of ACE2 and AXL in lung tissue were detected by real-time quantitative polymerase chain reaction and western blot.Results:Through data mining,it was found that there were 39 high-frequency traditional Chinese medicines for non-critical COVID-19 in the diagnosis and treatment guidelines.According to network pharmacology and molecular docking,30 highly targeted traditional Chinese drugs for COVID-19 were found.The new prescriptions for non-critical COVID-19 were comprehensively obtained,including Glycyrrhizae Radix,Ephedra Herba,Amygdalus Communis Vas,Gypsum Fibrosum,Descurainiae Semen,Atractylodes Lancea,Scutellariae Radix,Amomum Tsao-Ko Crevostet,Forsythiae Fructus,Pogostemon cablin,Magnolia Officinalis.Compared with the LPS-induced lung injury model group,the medium dose of the new prescription group had significantly alleviated pathological changes in lung tissue,decreased lung coefficient,decreased contents of IL-6,TNF-αand IL-1β,and increased mRNA and protein expression of ACE2 and AXL(P<0.05).Conclusion:Based on data mining,network pharmacology and molecular docking technology,the new prescription for non-critical COVID-19 established by this method has an anti-inflammatory effect on rats with acute lung injury induced by lipopolysaccharide and can provide a reference for clinicians to alleviate the symptoms related to non-critical COVID-19.

Rational Design of Two-Dimensional Magnetic Chromium Borides Based on First-Principles Calculation

Two-dimensional(2D) magnetic materials have been experimentally recognized recently,however,the Curie temperatures(TC) of known 2D systems are quite low.Generally,magnetic systems can be seen as constituent magnetic elements providing spins and the non-magnetic elements providing frameworks to host the magnetic elements.Short bond lengths between the magnetic and non-magnetic elements would be beneficial for strong magnetic interactions and thus high TC.Based on this,we propose to combine the magnetic element Cr and the non-magnetic element boron to design novel 2D magnetic systems.Using our self-developed software package IM2 ODE,we design a series of chromium-boride based 2D magnetic materials.Nine stable magnetic systems are identified.Among them,we find that CrB4-Ⅰ,CrB4-Ⅱ and CrBs-Ⅰ with common structural units [CrB8] are ferromagnetic metals with estimated TC of 270 K,120 K and 110 K,respectively.On the other hand,five CrB3 phases with structural units [Cr2B12] are antiferromagnetic metals.Additionally,we also find one antiferromagnetic semiconductor CrB2-Ⅰ.Our work may open new directions for identifying 2D magnetic systems with high TC.

Discussion on the mechanism of TCM treatment of climacteric syndrome based on TCM inheritance assistance system and network pharmacology

Background:To explore the law of traditional Chinese medicine in the treatment of climacteric syndrome,and to study the potential mechanism of traditional Chinese medicine therapy.Methods:For the relevant prescriptions collected from Chinese Journal Full-text Database,Wanfang medical network,PubMed and EMBASE were transferred to the traditional Chinese medicine inheritance assistant system(TCMISSV2.5)to conduct the nucleocentric drug group analysis.In this study,we used BATMAN-TCM(http://bionet.ncpsb.org/batman-tcm/)online analysis tool to analyze Therapeutic Target Database disease enrichment and Kyoto Gene and Genome Encyclopedia(KEGG)pathway enrichment,and Cytoscape(3.7.1)software was used to construct disease-target and KEGG pathway-target networks for visualization.Results:Among the 103 prescriptions,3 pairs of core drug combinations and 9 new prescriptions were selected by data mining.In the KEGG pathway of Zhimu(Anemarrhenae rhizoma)and Huangbo(Phellodendri Chinensis cortex),the most potential targets were found in the neural active ligand receptor interaction pathway.Conclusion:The compatibility of Anemarrhenae rhizoma and Phellodendri Chinensis cortex may play a role in the treatment of nervous system symptoms in patients with climacteric syndrome by interfering the neuroactive ligand receptor interaction signaling pathway.

Exploring the clinical significance of Yinqiao powder based on the compatibility of Chinese herbal formulas

Yinqiao powder comes from the book"Wenbing Tiaobian"(Detailed Analysis of Epidemic Warm Diseases)written by Wu Jutong in the Qing Dynasty(1636-1912),in which it is mentioned that"pungent-cool diaphoretic agent Yinqiao power is used to treat patients with fever,not aversion to cold but thirsty"Yinqiao powder is often used to treat Wind-warm syndrome,warm-heat syndrome and miscellaneous diseases caused by some pathogenic factors in Wei-fen syndrome(Wei-fen syndrome is the syndrome name of the disease and is often used to indicate the initial stage of exogenous febrile disease,which is the syndrome of the body's guard surface.)and upper energizer.With the further research and application of Yinqiao powder,it is more and more widely used in clinic.This article summarizes the clinical application of Yinqiao powder through the analysis of the prescription meaning,compatible prescriptions,decoction methods and other aspects of Yinqiao powder in order to provide more evidence for clinical treatment of febrile disease.At the same time,through the prescription thinking of Yinqiao powder,we can learn Wu Jutong's treatment principle and academic thought of"Shangjiao(Shangjiao is one of the three and is the upper part of the Sanjiao.Generally refers to the chest above the diaphragm,including the heart,lungs and throat.)is like a feather,not lightly".Wu Jutong's flexible use of Chinese medicine and the thought of syndrome differentiation and treatment are also worthy of our study and reference.

Clinical research progress of acupuncture therapy in the treatment of ankylosing spondylitis

Ankylosing spondylitis is a chronic inflammatory disease characterized by ankylosis of the spine and sacroiliac joints.The continuous development of this disease can cause damage to multiple organs.At present,modern medical treatment programs generally focus on symptomatic treatment such as analgesia and anti-inflammatory,which can relieve pain and inflammation to a certain extent,but there are many problems such as adverse drug reactions,and cannot be completely cured.Modern medical treatment of ankylosing spondylitis focuses on relieving symptoms,controlling disease activity,slowing disease progression,and reducing disability rates.As an important part of traditional Chinese medicine,acupuncture therapy,compared with modern medicine,has obvious advantages in the treatment of ankylosing spondylitis,such as good curative effect,quick effect,safety and low price,and no toxic and side effects.By reviewing the literature,it is found that there are a large number of clinical studies on the treatment of ankylosing spondylitis by acupuncture and moxibustion in recent years,and it is concluded that acupuncture and moxibustion has unique advantages in reducing local pain,alleviating inflammatory symptoms,improving joint function,preventing spinal deformity,and improving quality of life.Therefore,this study summarizes and reviews the relevant literature on different acupuncture and moxibustion therapy for ankylosing spondylitis,in order to provide ideas and solutions for the effective treatment of this disease.

The effect of cytisine on smoking cessation in patients with pulmonary tuberculosis

An article by Omara Dogar et al[1].that was first published in Lancet Global Health in 2020 revealed that current evidence didn’t support the addition of cytisine to brief behavioural support for the treatment of tobacco dependence in patients with tuberculosis.