Electrical contact materials are increasingly widely used,but the existing electric contact lubricants still have lots of room for improvement,such as anti-wear performance and lubrication life.Due to the excellent el...Electrical contact materials are increasingly widely used,but the existing electric contact lubricants still have lots of room for improvement,such as anti-wear performance and lubrication life.Due to the excellent electrical and lubrication properties,graphene shows great potential in lubricating the sliding electrical contact interface,but there is a lack of relevant research.Some researchers have studied the lubrication performance of graphene between the gold-coated/TiN-coated friction pair at an ultra-low current.However,the lubrication performance of graphene on more widely used electrical contact materials such as copper and its alloys under larger and more commonly used current or voltage conditions has not been reported.In this paper,we study the lubrication performance of graphene in the copper and its alloys sliding electrical contact interface under usual parameters,which is explored through four aspects:different substrates-copper and brass,different test methods-constant voltage and constant current,different normal loads and durability test.The experiments demonstrate that graphene can significantly reduce the friction and wear on brass and copper under the above test methods and parameters,with low contact resistance at the same time.Our work is expected to provide a new lubricant for electrical contact materials and contribute to enriching the tribological theory of graphene.展开更多
This paper presents a comprehensive exploration into the integration of Internet of Things(IoT),big data analysis,cloud computing,and Artificial Intelligence(AI),which has led to an unprecedented era of connectivity.W...This paper presents a comprehensive exploration into the integration of Internet of Things(IoT),big data analysis,cloud computing,and Artificial Intelligence(AI),which has led to an unprecedented era of connectivity.We delve into the emerging trend of machine learning on embedded devices,enabling tasks in resource-limited environ-ments.However,the widespread adoption of machine learning raises significant privacy concerns,necessitating the development of privacy-preserving techniques.One such technique,secure multi-party computation(MPC),allows collaborative computations without exposing private inputs.Despite its potential,complex protocols and communication interactions hinder performance,especially on resource-constrained devices.Efforts to enhance efficiency have been made,but scalability remains a challenge.Given the success of GPUs in deep learning,lever-aging embedded GPUs,such as those offered by NVIDIA,emerges as a promising solution.Therefore,we propose an Embedded GPU-based Secure Two-party Computation(EG-STC)framework for Artificial Intelligence(AI)systems.To the best of our knowledge,this work represents the first endeavor to fully implement machine learning model training based on secure two-party computing on the Embedded GPU platform.Our experimental results demonstrate the effectiveness of EG-STC.On an embedded GPU with a power draw of 5 W,our implementation achieved a secure two-party matrix multiplication throughput of 5881.5 kilo-operations per millisecond(kops/ms),with an energy efficiency ratio of 1176.3 kops/ms/W.Furthermore,leveraging our EG-STC framework,we achieved an overall time acceleration ratio of 5–6 times compared to solutions running on server-grade CPUs.Our solution also exhibited a reduced runtime,requiring only 60%to 70%of the runtime of previously best-known methods on the same platform.In summary,our research contributes to the advancement of secure and efficient machine learning implementations on resource-constrained embedded devices,paving the way for broader adoption of AI technologies in various applications.展开更多
Background and aims:Hepatocellular carcinoma(HCC),which is prevalent worldwide and has a high mortality rate,needs to be effectively diagnosed.We aimed to evaluate the significance of plasma microRNA-15a/16-1(miR-15a/...Background and aims:Hepatocellular carcinoma(HCC),which is prevalent worldwide and has a high mortality rate,needs to be effectively diagnosed.We aimed to evaluate the significance of plasma microRNA-15a/16-1(miR-15a/16)as a biomarker of hepatitis B virus-related HCC(HBV-HCC)using the machine learning model.This study was the first large-scale investigation of these two miRNAs in HCC plasma samples.Methods:Using quantitative polymerase chain reaction,we measured the plasma miR-15a/16 levels in a total of 766 participants,including 74 healthy controls,335 with chronic hepatitis B(CHB),47 with compensated liver cirrhosis,and 310 with HBV-HCC.The diagnostic performance of miR-15a/16 was examined using a machine learning model and compared with that of alpha-fetoprotein(AFP).Lastly,to validate the diagnostic efficiency of miR-15a/16,we performed pseudotemporal sorting of the samples to simulate progression from CHB to HCC.Results:Plasma miR-15a/16 was significantly decreased in HCC than in all control groups(P<0.05 for all).In the training cohort,the area under the receiver operating characteristic curve(AUC),sensitivity,and average precision(AP)for the detection of HCC were higher for miR-15a(AUC=0.80,67.3%,AP=0.80)and miR-16(AUC=0.83,79.0%,AP=0.83)than for AFP(AUC=0.74,61.7%,AP=0.72).Combining miR-15a/16 with AFP increased the AUC to 0.86(sensitivity 85.9%)and the AP to 0.85 and was significantly superior to the other markers in this study(P<0.05 for all),as further demonstrated by the detection error tradeoff curves.Moreover,miR-15a/16 impressively showed potent diagnostic power in early-stage,small-tumor,and AFP-negative HCC.A validation cohort confirmed these results.Lastly,the simulated follow-up of patients further validated the diagnostic efficiency of miR-15a/16.Conclusions:We developed and validated a plasma miR-15a/16-based machine learning model,which exhibited better diagnostic performance for the early diagnosis of HCC compared to that of AFP.展开更多
基金supported by the National Natural Science Foundation of China(No.12302127)Natural Science Foundation of Chongqing,China(No.cstc2021jcyj-msxmX0044)+1 种基金the Tribology Science Fund of State Key Laboratory of Tribology of China(No.SKLTKF20B02)the Experimental Technology Research Project of Southwest University(No.SYJ2023003).
文摘Electrical contact materials are increasingly widely used,but the existing electric contact lubricants still have lots of room for improvement,such as anti-wear performance and lubrication life.Due to the excellent electrical and lubrication properties,graphene shows great potential in lubricating the sliding electrical contact interface,but there is a lack of relevant research.Some researchers have studied the lubrication performance of graphene between the gold-coated/TiN-coated friction pair at an ultra-low current.However,the lubrication performance of graphene on more widely used electrical contact materials such as copper and its alloys under larger and more commonly used current or voltage conditions has not been reported.In this paper,we study the lubrication performance of graphene in the copper and its alloys sliding electrical contact interface under usual parameters,which is explored through four aspects:different substrates-copper and brass,different test methods-constant voltage and constant current,different normal loads and durability test.The experiments demonstrate that graphene can significantly reduce the friction and wear on brass and copper under the above test methods and parameters,with low contact resistance at the same time.Our work is expected to provide a new lubricant for electrical contact materials and contribute to enriching the tribological theory of graphene.
基金supported in part by Major Science and Technology Demonstration Project of Jiangsu Provincial Key R&D Program under Grant No.BE2023025in part by the National Natural Science Foundation of China under Grant No.62302238+2 种基金in part by the Natural Science Foundation of Jiangsu Province under Grant No.BK20220388in part by the Natural Science Research Project of Colleges and Universities in Jiangsu Province under Grant No.22KJB520004in part by the China Postdoctoral Science Foundation under Grant No.2022M711689.
文摘This paper presents a comprehensive exploration into the integration of Internet of Things(IoT),big data analysis,cloud computing,and Artificial Intelligence(AI),which has led to an unprecedented era of connectivity.We delve into the emerging trend of machine learning on embedded devices,enabling tasks in resource-limited environ-ments.However,the widespread adoption of machine learning raises significant privacy concerns,necessitating the development of privacy-preserving techniques.One such technique,secure multi-party computation(MPC),allows collaborative computations without exposing private inputs.Despite its potential,complex protocols and communication interactions hinder performance,especially on resource-constrained devices.Efforts to enhance efficiency have been made,but scalability remains a challenge.Given the success of GPUs in deep learning,lever-aging embedded GPUs,such as those offered by NVIDIA,emerges as a promising solution.Therefore,we propose an Embedded GPU-based Secure Two-party Computation(EG-STC)framework for Artificial Intelligence(AI)systems.To the best of our knowledge,this work represents the first endeavor to fully implement machine learning model training based on secure two-party computing on the Embedded GPU platform.Our experimental results demonstrate the effectiveness of EG-STC.On an embedded GPU with a power draw of 5 W,our implementation achieved a secure two-party matrix multiplication throughput of 5881.5 kilo-operations per millisecond(kops/ms),with an energy efficiency ratio of 1176.3 kops/ms/W.Furthermore,leveraging our EG-STC framework,we achieved an overall time acceleration ratio of 5–6 times compared to solutions running on server-grade CPUs.Our solution also exhibited a reduced runtime,requiring only 60%to 70%of the runtime of previously best-known methods on the same platform.In summary,our research contributes to the advancement of secure and efficient machine learning implementations on resource-constrained embedded devices,paving the way for broader adoption of AI technologies in various applications.
基金supported by Research and Development Planned Project in Key Areas of Guangdong Province(No.2019B110233002)National Natural Science Foundation of China(No.12171494 and 11931019)+3 种基金Natural Science Foundation of Guangdong Province,China(No.2022A1515011540)Guangdong Province Key Laboratory of Computational Science at the Sun Yat-sen University(No.2020B1212060032)Joint Key Projects of City and Hospital of Guangzhou Science and Technology(No.202201020422)General Planned Project of Guangzhou Science and Technology(No.202201010950).
文摘Background and aims:Hepatocellular carcinoma(HCC),which is prevalent worldwide and has a high mortality rate,needs to be effectively diagnosed.We aimed to evaluate the significance of plasma microRNA-15a/16-1(miR-15a/16)as a biomarker of hepatitis B virus-related HCC(HBV-HCC)using the machine learning model.This study was the first large-scale investigation of these two miRNAs in HCC plasma samples.Methods:Using quantitative polymerase chain reaction,we measured the plasma miR-15a/16 levels in a total of 766 participants,including 74 healthy controls,335 with chronic hepatitis B(CHB),47 with compensated liver cirrhosis,and 310 with HBV-HCC.The diagnostic performance of miR-15a/16 was examined using a machine learning model and compared with that of alpha-fetoprotein(AFP).Lastly,to validate the diagnostic efficiency of miR-15a/16,we performed pseudotemporal sorting of the samples to simulate progression from CHB to HCC.Results:Plasma miR-15a/16 was significantly decreased in HCC than in all control groups(P<0.05 for all).In the training cohort,the area under the receiver operating characteristic curve(AUC),sensitivity,and average precision(AP)for the detection of HCC were higher for miR-15a(AUC=0.80,67.3%,AP=0.80)and miR-16(AUC=0.83,79.0%,AP=0.83)than for AFP(AUC=0.74,61.7%,AP=0.72).Combining miR-15a/16 with AFP increased the AUC to 0.86(sensitivity 85.9%)and the AP to 0.85 and was significantly superior to the other markers in this study(P<0.05 for all),as further demonstrated by the detection error tradeoff curves.Moreover,miR-15a/16 impressively showed potent diagnostic power in early-stage,small-tumor,and AFP-negative HCC.A validation cohort confirmed these results.Lastly,the simulated follow-up of patients further validated the diagnostic efficiency of miR-15a/16.Conclusions:We developed and validated a plasma miR-15a/16-based machine learning model,which exhibited better diagnostic performance for the early diagnosis of HCC compared to that of AFP.