The lack of a reliable and specific marker for ferroptosis has hindered the advancement of treatments related to this cell death mechanism toward clinical application.A recent study published in Molecular Cell has ide...The lack of a reliable and specific marker for ferroptosis has hindered the advancement of treatments related to this cell death mechanism toward clinical application.A recent study published in Molecular Cell has identified hyperoxidized perox-iredoxin 3(PRDX3)as a promising marker for ferroptosis,open-ing up new avenues for monitoring and targeting ferroptosis in disease treatment.展开更多
Ferroptosis,an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsatu-rated-fatty-acid-containing phospholipids in cellular membranes,has recently been revealed to play an important r...Ferroptosis,an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsatu-rated-fatty-acid-containing phospholipids in cellular membranes,has recently been revealed to play an important role in radiotherapy-induced cell death and tumor suppression,and to mediate the synergy between radiotherapy and immunotherapy.In this review,we summarize known as well as putative mechanisms underlying the crosstalk between radiotherapy and fer-roptosis,discuss the interactions between ferroptosis and other forms of regulated cell death induced by radiotherapy,and explore combination therapeutic strategies targeting ferroptosis in radiotherapy and immunotherapy.This review will provide important frameworks for future investigations of ferroptosis in cancer therapy.展开更多
基金Research in the authors’laboratory has been supported by the University of Texas MD Anderson Cancer Center,National Institutes of Health grants R01CA181196,R01CA244144,R01CA247992,R01CA269646,and U54CA274220Cancer Prevention&Research Institute of Texas grant RP230072(to B.G.)Cancer Center Support(Core)Grant P30 CA016672 from The National Cancer Institute(to the University of Texas MD Anderson Cancer Center).
文摘The lack of a reliable and specific marker for ferroptosis has hindered the advancement of treatments related to this cell death mechanism toward clinical application.A recent study published in Molecular Cell has identified hyperoxidized perox-iredoxin 3(PRDX3)as a promising marker for ferroptosis,open-ing up new avenues for monitoring and targeting ferroptosis in disease treatment.
基金Radiation Oncology Strategic Initiatives(ROSI)from The University of Texas MD Anderson Cancer Center。
文摘Ferroptosis,an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsatu-rated-fatty-acid-containing phospholipids in cellular membranes,has recently been revealed to play an important role in radiotherapy-induced cell death and tumor suppression,and to mediate the synergy between radiotherapy and immunotherapy.In this review,we summarize known as well as putative mechanisms underlying the crosstalk between radiotherapy and fer-roptosis,discuss the interactions between ferroptosis and other forms of regulated cell death induced by radiotherapy,and explore combination therapeutic strategies targeting ferroptosis in radiotherapy and immunotherapy.This review will provide important frameworks for future investigations of ferroptosis in cancer therapy.
