Novel circular RNA expression profile of uveal melanoma revealed by microarray

Objective: The present study aimed to investigate circular RNA(circRNA) expression in uveal melanoma(UM).Methods: First,we used microarray to compare the expression profiles of circRNA in five UM samples and five normal uvea tissues.Next,bioinformatics analyses,including gene ontology(GO) analysis and pathway analysis,were applied to study these differentially expressed circRNAs to predict pathogenic pathways that may be involved.Quantitative real-time polymerase chain reaction(qRT-PCR) in 20 UM samples and 20 normal uvea samples was used to confirm the circRNA expression profiles obtained from the microarray data.Finally,we analyzed the interaction between validated circRNAs and their potential cancer-associated miRNA targets.Results: In total,50,579 circRNAs [fold change(FC) ≥2.0; P<0.05],including 20,654 up-regulated and 29,925 down-regulated circRNAs,were identified as differentially expressed between UM tissues and normal uvea tissues.We used qRT-PCR to verify seven dysregulated circRNAs indicated by the microarray data,including hsa_circ_0119873,hsa_circ_0128533,hsa_circ_0047924,hsa_circ_0103232,hsa-circRNA10628-6,hsa_circ_0032148 and hsa_circ_0133460,which may be promising candidates to study future molecular mechanisms.Conclusions: This study explored,for the first time,the abnormal expression of circRNAs in UM and described the expression profile of circRNAs,providing a new potential target for the mechanism of UM and future treatment of UM.

Reconstructions for Continuous-Wave Diffuse Optical Tomography by a Globally Convergent Method

In this paper, a novel reconstruction method is presented for Near Infrared (NIR) 2-D imaging to recover optical absorption coefficients from laboratory phantom data. The main body of this work validates a new generation of highly efficient reconstruction algorithms called “Globally Convergent Method” (GCM) based upon actual measurements taken from brain-shape phantoms. It has been demonstrated in earlier studies using computer-simulated data that this type of reconstructions is stable for imaging complex distributions of optical absorption. The results in this paper demonstrate the excellent capability of GCM in working with experimental data measured from optical phantoms mimicking a rat brain with stroke.

Ti_(3)C_(2)T_(x)MXene wrapped,carbon-coated porous Si sheets for improved lithium storage performance

Si-based materials have shown great potential as lithium-ion batteries(LIBs)anodes due to their natural reserves and high theoretical capacity.However,the large volume changes during cycles and poor conductivity of Si lead to rapid capacity decay and poor cycling stability,ultimately limiting their commercial applications.Herein,we have skillfully utilized the microporous MCM-22 zeolite as the unique silicon source to produce porous Si(pSi)sheets by a simple magnesiothermic reduction,followed by a carbon coating and further Ti_(3)C_(2)T_(x)MXene assembly,obtaining the ternary pSi@NC@TNSs composite.In the design,porous Si sheets provide more active sites and shorten Li-ion transport paths for electrochemical reactions.The N-doped carbon(NC)layer serves as a bonding layer to couple pSi and Ti_(3)C_(2)T_(x).The conductive network formed by 2D Ti_(3)C_(2)T_(x)and medium NC layer effectively enhances the overall charge transport of the electrode material,and helps to stabilize the electrode structure.Therefore,the as-made pSi@NC@TNSs anode delivers an improved lithium storage performance,exhibiting a high reversible capacity of 925 mAh/g at 0.5 A/g after 100 cycles.This present strategy provides an effective way towards high-performance Si-based anodes for LIBs.

Design and Analysis of Biomimetic Nose Cone for Morphing of Aerospace Vehicle

当穿透并且重入空气时， Morphing 能力绝对是重要的让太空车辆获得气体动力学，活动性和飞行控制的占优势的功能。然而，为存在太空车辆的挑战尚待活泼地改变它鼻子锥的结构。这份报纸在由调整它的生物形态的形状提高蜜蜂的飞行特征的蜜蜂腹部上执行很多观察实验。morphing 结构从蜜蜂腹部被采用改进轴的可伸缩性和太空车辆的弯曲性质，它能导致超级演习的飞行性能。与最佳设计和拓扑学的方法结合了，新仿生的 morphing 结构被建议并且适用于太空车辆的 morphing 鼻子锥的设计。而且，模拟被进行优化 morphing 鼻子锥的结构的参数。biomimetic 鼻子锥的这个概念图案将提供一个有效方法让太空车辆减少空气动力学拖。

Single-grain cutting based modeling of abrasive belt wear in cylindrical grinding

A systematic wear model of the cylindrical grinding process with an alumina abrasive belt from the perspective of single grain sliding wear was established in this study.The model consists of three parts:a single cutting force model derived by applying a stress integration method,a single grain wear height analysis based on the wear rate of alumina,and a grinding mileage prediction of multiple grains with Gaussian distributed protrusion heights.Cutting force,single grain wear height and full‐size grinding mileage verification experiments were conducted.The results indicated that the established model was in reasonable agreement with the experimental outcomes,which suggests that this model could be useful in the industry to predict the wear process of abrasive belts.

Mapping China’s offshore mariculture based on dense time-series optical and radar data

Due to the weak information about cultural targets in the complex marine environment,an omission problem exists in large-scale mariculture extraction using single-view and single-source images.To overcome this problem,we developed a mariculture extraction method that combines dense time-series Sentinel-2 and Sentinel-1 data.A high-precision Chinese mariculture distribution map for 2020 was produced with an overall accuracy of 94.00%and a kappa coefficient of 0.91.The results show that(1)the total area of mariculture was 1173249.22 ha on the national scale,which was significantly larger than the previous studies(459595.70 and 205920.28 ha,respectively),with Shandong Province(39.09%)having the largest proportion;(2)China’s mariculture presented a spatial distribution characteristic of‘Denser North and Sparser South’,and mariculture was centralized in the coastal zones of the northern provinces(60.76%)rather than the southern provinces;(3)the official production statistics and remote sensing-derived mariculture area revealed a highly corresponding trend at the provincial level,with an R2 reaching 0.78,which is much higher than the 0.07 and 0.41 values of the comparison data.The results directly provide data reference for mariculture production estimation and site selection or ideas for mariculture extraction in other regions and globally.