Background:To provide an understanding of important aspects of the participant recruitment and data collec-tion,become aware of any potential problems,and obtain necessary information in order to design a large-scale ...Background:To provide an understanding of important aspects of the participant recruitment and data collec-tion,become aware of any potential problems,and obtain necessary information in order to design a large-scale randomized controlled trial(RCT)for lung cancer and colorectal cancer(CRC)screening in China.Methods:This feasibility study was a multicentered,open-label,pilot randomized trial.A total of 2696 participants who were at high risk of lung cancer were recruited from three screening centers and randomly allocated to arm 1(n=894),annual low-dose computed tomography(LDCT)plus a baseline colonoscopy;arm 2(n=902),biennial LDCT plus annual fecal immunochemical test(FIT)with OC-Sensor(OC-FIT);and arm 3(n=900),annual Insure-FIT plus Septin 9 blood test.Information on randomization,compliance,positivity rate,cancer case detection,and contamination with screening for lung cancer and CRC were collected.Results:Participant characteristics were similar across study arms.The compliance rate of annual LDCT screening in arm 1 was 86.4%(95%CI:83.9%,88.5%)at baseline(T0),and 69.0%(95%CI:65.8%,72.0%)and 70.7%(95%CI:67.6%,73.7%)at the following two rounds(T1 and T2).The compliance rates of biennial LDCT screening in arm 2 were similar to those in arm 1 in the corresponding rounds.The compliance rate was 55.5%(95%CI:52.2%,58.8%)for colonoscopy in arm 1,while the compliance rates of OC-FIT,Insure-FIT,and the Septin 9 test in arms 2 and 3 were all approximately 90%at T0,decreasing to 65%-80%at T1 and T2.The positivity rate,cancer case detection rate,and contamination rate of screening for lung cancer and CRC were also reported.Conclusion:In this pilot study,the feasibility of an RCT in China of lung cancer and CRC screening was demon-strated.展开更多
The electrical conductivity of serpentine is measured at 1.0-3.0 GPa and 300-870℃. The effect of frequencies on electrical conductivity measurement is analyzed. The conduction mechanisms of serpentine before and afte...The electrical conductivity of serpentine is measured at 1.0-3.0 GPa and 300-870℃. The effect of frequencies on electrical conductivity measurement is analyzed. The conduction mechanisms of serpentine before and after dehydration are discussed. Our experimental results show that the electrical conductivity of serpentine increases significantly after展开更多
Introduction Submucosal tunneling endoscopic resection(STER)for the treatment of upper gastrointestinal submucosal tumors originating from the muscularis propria was first introduced by Xu et al.[1]in 2012.It has been...Introduction Submucosal tunneling endoscopic resection(STER)for the treatment of upper gastrointestinal submucosal tumors originating from the muscularis propria was first introduced by Xu et al.[1]in 2012.It has been demonstrated to be safe and effective for treating small(<3.5 cm)esophageal leiomyoma.However,sometimes the esophageal leiomyoma may be a giant mass and protrude into the mediastinum.展开更多
基金the National Natural Science Foundation of China(No. 81460561and 81360502)Guangxi Natural Science Foundation(No.2014GXNSFAA118225)+1 种基金the Program of Key Laboratory of High-Incidence-Tumor Prevention and Treatment(Guangxi Medical University),the Ministry of Education,China(No. GKE2018-09and GK2018-11)the Innovative Project of Postgraduate Majored in Biomedical Engineering, Guangxi Medical University (No. SG2018010).
文摘Background:To provide an understanding of important aspects of the participant recruitment and data collec-tion,become aware of any potential problems,and obtain necessary information in order to design a large-scale randomized controlled trial(RCT)for lung cancer and colorectal cancer(CRC)screening in China.Methods:This feasibility study was a multicentered,open-label,pilot randomized trial.A total of 2696 participants who were at high risk of lung cancer were recruited from three screening centers and randomly allocated to arm 1(n=894),annual low-dose computed tomography(LDCT)plus a baseline colonoscopy;arm 2(n=902),biennial LDCT plus annual fecal immunochemical test(FIT)with OC-Sensor(OC-FIT);and arm 3(n=900),annual Insure-FIT plus Septin 9 blood test.Information on randomization,compliance,positivity rate,cancer case detection,and contamination with screening for lung cancer and CRC were collected.Results:Participant characteristics were similar across study arms.The compliance rate of annual LDCT screening in arm 1 was 86.4%(95%CI:83.9%,88.5%)at baseline(T0),and 69.0%(95%CI:65.8%,72.0%)and 70.7%(95%CI:67.6%,73.7%)at the following two rounds(T1 and T2).The compliance rates of biennial LDCT screening in arm 2 were similar to those in arm 1 in the corresponding rounds.The compliance rate was 55.5%(95%CI:52.2%,58.8%)for colonoscopy in arm 1,while the compliance rates of OC-FIT,Insure-FIT,and the Septin 9 test in arms 2 and 3 were all approximately 90%at T0,decreasing to 65%-80%at T1 and T2.The positivity rate,cancer case detection rate,and contamination rate of screening for lung cancer and CRC were also reported.Conclusion:In this pilot study,the feasibility of an RCT in China of lung cancer and CRC screening was demon-strated.
文摘The electrical conductivity of serpentine is measured at 1.0-3.0 GPa and 300-870℃. The effect of frequencies on electrical conductivity measurement is analyzed. The conduction mechanisms of serpentine before and after dehydration are discussed. Our experimental results show that the electrical conductivity of serpentine increases significantly after
文摘Introduction Submucosal tunneling endoscopic resection(STER)for the treatment of upper gastrointestinal submucosal tumors originating from the muscularis propria was first introduced by Xu et al.[1]in 2012.It has been demonstrated to be safe and effective for treating small(<3.5 cm)esophageal leiomyoma.However,sometimes the esophageal leiomyoma may be a giant mass and protrude into the mediastinum.
