To the Editor,Sarcopenia includes the presence of both low skeletal muscle mass and low skeletal muscle function(strength and/or physical performance).A consensus definition of sarcopenia in cirrhosis patients is the ...To the Editor,Sarcopenia includes the presence of both low skeletal muscle mass and low skeletal muscle function(strength and/or physical performance).A consensus definition of sarcopenia in cirrhosis patients is the phenotypic manifestation of the loss of muscle mass.1 On the basis of body composition analyses,sarcopenic obesity(SO)is defined as a combination of obesity and sarcopenia.2 Sarcopenia and SO have been detected associating with poor prognosis,including frailty,poor survival,infec-tion,and a greater length of hospital stay,physical impairment,and mortality.展开更多
Three new sesquiterpene glycosides,named codonopsesquilosides A C(1 3),were isolated from an aqueous extract of the dried roots of Codonopsis pilosula.Their structures including absolute configurations were determined...Three new sesquiterpene glycosides,named codonopsesquilosides A C(1 3),were isolated from an aqueous extract of the dried roots of Codonopsis pilosula.Their structures including absolute configurations were determined by spectroscopic and chemical methods.These glycosides are categorized as C_(15) carotenoid(1),gymnomitrane(2),and eudesmane(3)types of sesquiterpenoids,respectively.Compound 1 is the first diglycoside of C_(15) carotenoids to be reported.Compound 2 represents the second reported example of gymnomitrane-type sesquiterpenoids from higher plants.The absolute configurations were supported by comparison of the experimental circular dichroism(CD)spectra with the calculated electronic CD(ECD)spectra of 13,their aglycones,and model compounds based on quantummechanical time-dependent density functional theory.The influences of the glycosyls on the calculated ECD spectra of the glycosidic sesquiterpenoids,as well as some nomenclature and descriptive problems with gymnomitrane-type sesquiterpenoids are discussed.展开更多
Four new acetylenes (1-4) and one new unsaturated to-hydroxy fatty acid (5), together with known analogues, were isolated from an aqueous extract of Codonopsis pilosula roots. Their structures were determined by spect...Four new acetylenes (1-4) and one new unsaturated to-hydroxy fatty acid (5), together with known analogues, were isolated from an aqueous extract of Codonopsis pilosula roots. Their structures were determined by spectroscopic and chemical methods. The new acetylenes are categorized as an unusual cyclotetradecatrienynone (1), tetradocenynetriol (2), and rare octenynoic acids (3 and 4), respectively, and 3 and 4 are possibly derived from oxidative metabolic degradation of 1 and/or 2. The absolute configuration of I. was assigned by comparison of the experimental circular dichroism (Cl)) spectrum with the calculated electronic circular dichroism (ECD) spectra of stereoisomers based on the quantum-mechanical time-dependent density functional theory, while the configuration of 2 was assigned by using modified Mosher's method based on the MPA determination rule of AoRs values for diols. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier By.展开更多
基金supported by grants from the National Natural Science Foundation of Shandong Province (No.ZR202103040311).
文摘To the Editor,Sarcopenia includes the presence of both low skeletal muscle mass and low skeletal muscle function(strength and/or physical performance).A consensus definition of sarcopenia in cirrhosis patients is the phenotypic manifestation of the loss of muscle mass.1 On the basis of body composition analyses,sarcopenic obesity(SO)is defined as a combination of obesity and sarcopenia.2 Sarcopenia and SO have been detected associating with poor prognosis,including frailty,poor survival,infec-tion,and a greater length of hospital stay,physical impairment,and mortality.
基金Financial support from the National Natural Sciences Foundation of China(NNSFC,Grant Nos.30825044 and 20932007)the Program for Changjiang Scholars and Innovative Research Team in University(PCSIRT,Grant No.IRT1007)the National Science and Technology Project of China(Nos.2012ZX09301002-002 and 2011ZX09307-002-01)
文摘Three new sesquiterpene glycosides,named codonopsesquilosides A C(1 3),were isolated from an aqueous extract of the dried roots of Codonopsis pilosula.Their structures including absolute configurations were determined by spectroscopic and chemical methods.These glycosides are categorized as C_(15) carotenoid(1),gymnomitrane(2),and eudesmane(3)types of sesquiterpenoids,respectively.Compound 1 is the first diglycoside of C_(15) carotenoids to be reported.Compound 2 represents the second reported example of gymnomitrane-type sesquiterpenoids from higher plants.The absolute configurations were supported by comparison of the experimental circular dichroism(CD)spectra with the calculated electronic CD(ECD)spectra of 13,their aglycones,and model compounds based on quantummechanical time-dependent density functional theory.The influences of the glycosyls on the calculated ECD spectra of the glycosidic sesquiterpenoids,as well as some nomenclature and descriptive problems with gymnomitrane-type sesquiterpenoids are discussed.
基金Financial support from the National Natural Sciences Foundation of China,China (NSFCNos.30825044 and 20932007)+1 种基金the Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT,No.IRT1007)the National Science and Technology Project of China (Nos.2012ZX09301002-002 and 2011ZX09307-002-01)
文摘Four new acetylenes (1-4) and one new unsaturated to-hydroxy fatty acid (5), together with known analogues, were isolated from an aqueous extract of Codonopsis pilosula roots. Their structures were determined by spectroscopic and chemical methods. The new acetylenes are categorized as an unusual cyclotetradecatrienynone (1), tetradocenynetriol (2), and rare octenynoic acids (3 and 4), respectively, and 3 and 4 are possibly derived from oxidative metabolic degradation of 1 and/or 2. The absolute configuration of I. was assigned by comparison of the experimental circular dichroism (Cl)) spectrum with the calculated electronic circular dichroism (ECD) spectra of stereoisomers based on the quantum-mechanical time-dependent density functional theory, while the configuration of 2 was assigned by using modified Mosher's method based on the MPA determination rule of AoRs values for diols. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier By.
