To the Editor:Malignant pleural effusion(MPE)is a collection of a large amount of exudativeuid in the pleural cavity that mainly originates from pleural metastases in patients with malignant tumors.The formation of MP...To the Editor:Malignant pleural effusion(MPE)is a collection of a large amount of exudativeuid in the pleural cavity that mainly originates from pleural metastases in patients with malignant tumors.The formation of MPE is related to angiogenesis,increased vascular permeability,lymphatic obstruction,immune reactions,and the tumor metastasis microenvironment,but molecular-based diagnostic and next-generation therapeutic strategies for MPE are still lacking.Exosomes are vesicles with a double-layered lipid membrane structure that are widely distributed in bodyuids and can be produced by almost all cells.Increased evidence has shown that exosomes are related to the development of MPE and are correlated with the efcacy of and response to targeted therapy or immunotherapy.Although exosomes are one of the main components of MPE,the source and functional role of exosomes in MPE are still unclear.展开更多
基金Key R&D Plan of Jiangxi Province(No.2021BBG71006)Zhejiang Provincial Basic Public Welfare Research Project(No.GF19H160028)Key project of Science and Technology Innovation of Health Commission of Jiangxi Province(Nos.2023ZD005 and 2024ZD008)
文摘To the Editor:Malignant pleural effusion(MPE)is a collection of a large amount of exudativeuid in the pleural cavity that mainly originates from pleural metastases in patients with malignant tumors.The formation of MPE is related to angiogenesis,increased vascular permeability,lymphatic obstruction,immune reactions,and the tumor metastasis microenvironment,but molecular-based diagnostic and next-generation therapeutic strategies for MPE are still lacking.Exosomes are vesicles with a double-layered lipid membrane structure that are widely distributed in bodyuids and can be produced by almost all cells.Increased evidence has shown that exosomes are related to the development of MPE and are correlated with the efcacy of and response to targeted therapy or immunotherapy.Although exosomes are one of the main components of MPE,the source and functional role of exosomes in MPE are still unclear.
