The Impact of a Comprehensive Program on College Success of Academically and Socioeconomically Disadvantaged Students

Low rates in college graduation and persistence have been a significant and persistent issue among urban high school graduates in the Unites States of America,especially for the academically and socioeconomically disadvantaged student population.In response to a college completion initiative,higher education institutions in one large city have joined forces to battle this issue.The purpose of this mixed-methods study was to examine the effects of one such university’s comprehensive support program on public high school graduates’success in college graduation and persistence,and identifies a set of unique high impact practices that have contributed to the success of the program.

Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y_(12 ) signaling pathway

Ticagrelor is the first reversibly binding oralP2Y_(12) receptor antagonist to inhibit platelet activation and has been approved by the Food and Drug Administration for the treatment of coronary artery disease. At present, the other pharmacological functions of ticagrelor remain poorly understood. The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome plays a critical role in the innate immune system, but its excessive activation also contributes to the pathogenesis of complex diseases. In this study, we systematically examined the effects of ticagrelor on the NLRP3 inflammasome and found that ticagrelor inhibits NLRP3 inflammasome activation in macrophages independent of its classic inhibitory effect on theP2Y_(12) signaling pathway. Further mechanistic studies demonstrate that ticagrelor attenuates the oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) by blocking chloride efflux, an effect achieved through the degradation of chloride intracellular channel proteins (CLICs) and blockade of the translocation of CLICs to the plasma membrane. Moreover, experiments on lipopolysaccharide-induced sepsis and alum-induced peritonitis in mice confirmed that ticagrelor mitigates the severity of systemic inflammation independent ofP2Y_(12) receptor antagonism. Importantly, oral administration of ticagrelor rapidly and strongly inhibited NLRP3 inflammasome activation in peripheral blood mononuclear cells from patients with acute coronary syndrome. Overall, our study reveals a novel pharmacological function of ticagrelor in addition to its classic antiplatelet properties, which suggests that ticagrelor may serve as a potential therapeutic agent for use in NLRP3-associated diseases.

Learning to recognize misaligned hyperfine orbital angular momentum modes

Orbital angular momentum(OAM)-carrying beams have received extensive attention due to their high-dimensional characteristics in the context of free-space optical communication.However,accurate OAM mode recognition still suffers from reference misalignment of lateral displacement,beam waist size,and initial phase.Here we propose a deep-learning method to exquisitely recognize OAM modes under misalignment by using an alignment-free fractal multipoint interferometer.Our experiments achieve 98.35% recognizing accuracy when strong misalignment is added to hyperfine OAM modes whose Bures distance is 0.01.The maximum lateral displacement we added with respect to the perfectly on-axis beam is about±0.5 beam waist size.This work offers a superstable proposal for OAM mode recognition in the application of free-space optical communication and allows an increase of the communication capacity.

Multiple-order line rogue wave,lump and its interaction,periodic,and cross-kink solutions for the generalized CHKP equation

The multiple-order line rogue wave solutions method is emp loyed for searching the multiple soliton solutions for the generalized(2+1)-dimensional Camassa-HolmKadomtsev-Petviashvili(CHKP)equation,which contains first-order,second-order,and third-order waves solutions.At the critical point,the second-order derivative and Hessian matrix for only one point will be investigated and the lump solution has one minimum value.For the case,the lump solution will be shown the bright-dark lump structure and for another case can be present the dark lump structure-two small peaks and one deep hole.Also,the interaction of lump with periodic waves and the interaction between lump and soliton can be obtained by introducing the Hirota forms.In the meanwhile,the cross-kink wave and periodic wave solutions can be gained by the Hirota operator.The physical phenomena of these gained multiple soliton solutions are analyzed and indicated in figures by selecting suitable values.We alternative offer that the determining method is general,impressive,outspoken,and powerful and can be exerted to create exact solutions of various kinds of nonlinear models originated in mathematical physics and engineering.