Central Asia,a crucible of prehistoric and historical Trans-Eurasian interactions,has been pivotal in shaping cultural exchanges,population dynamics,and genetic admixture.Recent insights from ancient DNA studies have ...Central Asia,a crucible of prehistoric and historical Trans-Eurasian interactions,has been pivotal in shaping cultural exchanges,population dynamics,and genetic admixture.Recent insights from ancient DNA studies have shed light on the extensive population turnover within this region,encompassing a spectrum of groups from Paleolithic huntergatherers to Holocene herders and the nomadic pastoralist empires of historical times.The genomic analysis of ancient pathogens across the Eurasian steppe has further deepened our understanding of pathogen origins,clonal expansions,and the intricate processes of host-pathogen coevolution in relation to varying pathogen exposures and their spread.We consolidate the latest findings pertaining to the ancient human and pathogen genomes of Central Asia,elucidating their profound influence on the genomic tapestry of contemporary Central Asians.A notable gap in the current genomic databases for Central Asia is underscored,particularly within the scope of genomics-driven precision medicine.We stress the urgent need for the development of extensive,region-specific genomic resources that hold promise for revealing the genetic blueprints underlying human traits and diseases,refining polygenic scoring models for predictive medicine,and bolstering genomic research endeavors across Central Asia.展开更多
基金supported by the National Natural Science Foundation of China(82202078)supported by the Major Project of the National Social Science Foundation of China(23&ZD203)+7 种基金the Open Project of the Key Laboratory of ForensicGenetics of the Ministry of Public Security(2022FGKFKT05)the Center for Archaeological Science of Sichuan University(23SASA01)supported by the 1‧3‧5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC20002)the Sichuan Science and Technology Program(2024NSFSC1518)supported by the National Key Research and Development Program of China(No.2023YFC2605400)the National Natural Science Foundation of China(32288101,32030020)the Shanghai Science and Technology Commission Program(23JS1410100)the Office of Global Partnerships(Key Projects Development Fund).
文摘Central Asia,a crucible of prehistoric and historical Trans-Eurasian interactions,has been pivotal in shaping cultural exchanges,population dynamics,and genetic admixture.Recent insights from ancient DNA studies have shed light on the extensive population turnover within this region,encompassing a spectrum of groups from Paleolithic huntergatherers to Holocene herders and the nomadic pastoralist empires of historical times.The genomic analysis of ancient pathogens across the Eurasian steppe has further deepened our understanding of pathogen origins,clonal expansions,and the intricate processes of host-pathogen coevolution in relation to varying pathogen exposures and their spread.We consolidate the latest findings pertaining to the ancient human and pathogen genomes of Central Asia,elucidating their profound influence on the genomic tapestry of contemporary Central Asians.A notable gap in the current genomic databases for Central Asia is underscored,particularly within the scope of genomics-driven precision medicine.We stress the urgent need for the development of extensive,region-specific genomic resources that hold promise for revealing the genetic blueprints underlying human traits and diseases,refining polygenic scoring models for predictive medicine,and bolstering genomic research endeavors across Central Asia.
