期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Heterologous expression in transgenic mosquitoes
1
作者 Santhosh PK yuhua deng +1 位作者 Weidong Gu Xiaoguang Chen 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2010年第3期244-250,共7页
Arthropod-borne diseases such as malaria and dengue virus afflict billions of people worldwide imposing major economic and social burdens.Control of such pathogens is mainly performed by vector management and treatmen... Arthropod-borne diseases such as malaria and dengue virus afflict billions of people worldwide imposing major economic and social burdens.Control of such pathogens is mainly performed by vector management and treatment of affected individuals with drugs.The failure of these conventional approaches due to emergence of insecticide-resistant insects and drug-resistant parasites demonstrate the need of novel and efficacious control strategies to combat these diseases.Genetic modification(GM) of mosquito vectors to impair their ability to be infected and transmit pathogens has emerged as a new strategy to reduce transmission of many vector-borne diseases and deliver public health gains.Several advances in developing transgenic mosquitoes unable to transmit pathogens have gained support,some of them attempt to manipulate the naturally occurring endogenous refractory mechanisms,while others initiate the identification of an exogenous foreign gene which disrupt the pathogen development in insect vectors. Heterologous expression of transgenes under a native or heterologous promoter is important for the screening and effecting of the transgenic mosquitoes.The effect of the transgene on mosquito fitness is a crucial parameter influencing the success of this transgenic approach.This review examines these two aspects and describes the basic research work that has been accomplished towards understanding the complex relation between the parasite and its vector and focuses on recent advances and perspectives towards construction of transgenic mosquitoes refractory to vector-borne disease transmission. 展开更多
关键词 ANOPHELES Fitness load MALARIA TRANSGENE TRANSPOSABLE element Vector
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部