Porous titanium(Ti)scaffolds have been extensively utilized as bone substitute scaffolds due to their superior biocompatibility and excellent mechanical properties.However,naturally formed TiO2 on the surface limits f...Porous titanium(Ti)scaffolds have been extensively utilized as bone substitute scaffolds due to their superior biocompatibility and excellent mechanical properties.However,naturally formed TiO2 on the surface limits fast osseointegration.Different biomolecules have been widely utilized to overcome this issue;however,homogeneous porous Ti scaffolds could not simultaneously deliver multiple biomolecules that have different release behaviors.In this study,functionally graded porous Ti scaffolds(FGPTs)with dense inner and porous outer parts were fabricated using a two-body combination and densification procedure.FGPTs with growth factor(BMP-2)and antibiotics(TCH)exhibited suitable mechanical properties as bone substituting material and presented good structural stability.The release of BMP-2 was considerably prolonged,whereas the release of TCH was comparable to that of homogenous porous titanium scaffolds(control group).The osteogenic differentiation obtained using FGPTs was maintained due to the prolonged release of BMP-2.The antimicrobial properties of these scaffolds were verified using S.aureus in terms of prior release time.In addition,various candidates for graded porous Ti scaffolds with altered pore characteristics were presented.展开更多
基金supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT)(Nos. 2021R1I1A1A01043176 and2021R1A2C1091301)the framework of international cooperation program managed by the National Research Foundation of Korea (No.2021K2A9A2A06037540)+3 种基金Korean Fund for Regenerative Medicine funded by Ministry of Science and ICTMinistry of Health and Welfare (No. 2021M3E5E5096420, Republic of Korea)Korea Medical Device Development Fund grant funded by the Korea government(the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health&Welfare, Republic of Korea, the Ministry of Food and Drug Safety)(Project Number:202011B29)the GRRC program of the Gyeo nggi Province (Grant Number GRRC-KPU2021-A01, Multi-material Machining Innovative Technology Research Center)
文摘Porous titanium(Ti)scaffolds have been extensively utilized as bone substitute scaffolds due to their superior biocompatibility and excellent mechanical properties.However,naturally formed TiO2 on the surface limits fast osseointegration.Different biomolecules have been widely utilized to overcome this issue;however,homogeneous porous Ti scaffolds could not simultaneously deliver multiple biomolecules that have different release behaviors.In this study,functionally graded porous Ti scaffolds(FGPTs)with dense inner and porous outer parts were fabricated using a two-body combination and densification procedure.FGPTs with growth factor(BMP-2)and antibiotics(TCH)exhibited suitable mechanical properties as bone substituting material and presented good structural stability.The release of BMP-2 was considerably prolonged,whereas the release of TCH was comparable to that of homogenous porous titanium scaffolds(control group).The osteogenic differentiation obtained using FGPTs was maintained due to the prolonged release of BMP-2.The antimicrobial properties of these scaffolds were verified using S.aureus in terms of prior release time.In addition,various candidates for graded porous Ti scaffolds with altered pore characteristics were presented.
