Background: The rubella outbreak in Japan has not yet been eliminated. In particular, an outbreak of congenital rubella syndrome has recently become a public health problem in Japan. The World Health Organization has ...Background: The rubella outbreak in Japan has not yet been eliminated. In particular, an outbreak of congenital rubella syndrome has recently become a public health problem in Japan. The World Health Organization has set an elimination target of 2015 for measles in Japan. However, an outbreak of measles occurred in Japan between 2007 and 2008. Starting in April 2006, the measles and rubella vaccines were administered twice, once when a child reached 1 year old and once when the child was 5 - 6 years old (just before starting elementary school). Between October of 1978 and 2006, children were vaccinated only once for measles and rubella. Design: During the study enrollment period (2011-2013), the serum antibody titers of measles and rubella were measured in pediatric patients (n = 163) in the Tokyo Takanawa Hospital. Results: The prevalence rates of the two diseases indicated that only one vaccination was insufficient to protect against infection. Conclusions: Our studies have determined that it was important to vaccinate children twice for measles and rubella during early infancy.展开更多
Background: The objective of this study is to determine whether analyze of the infant’s pain associated with diphtheria-pertussis-tetanus (DPT) immunization is useful for vaccination in children. It is not known whet...Background: The objective of this study is to determine whether analyze of the infant’s pain associated with diphtheria-pertussis-tetanus (DPT) immunization is useful for vaccination in children. It is not known whether the immunization pain can be prevented with the adequate choice of DPT vaccines among several manufacturers in Japan. Further, it is not clear whether the difference of the reaction during vaccination between gender and age. Design: Three manufacturer’s Japanese DPT vaccines were used in this study. The parents assessed their infant’s pain on a modified visual analogue scale (MVAS), the start of the crying and total crying time during the immunization. Results: The A manufacturer’s DPT vaccine was significantly lower on the proportion of crying, the duration of crying and MVAS score than the other two manufacturer’s DPT vaccines. The proportion of crying, the duration of crying and MVAS score was lower in the boy than in the girl. On the other hand, it had not found the difference of their reactions with age. Conclusions: Our studies have found that the adequate choice of DPT vaccine decreased vaccination pain. The studies also indicate that some tendencies with vaccinations were shown in children. To consider these tendencies was useful in performing less painful vaccination.展开更多
Periodic fever with aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is an autoimmune disorder and the most common disorder characterized by periodic fever in children. A male patient has been followed ...Periodic fever with aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is an autoimmune disorder and the most common disorder characterized by periodic fever in children. A male patient has been followed up from 11 months to 10 years of age because of repeated high fever. We prescribed antifebriles and antibiotics for each febrile episode without a beneficial effect to him each time. He required several days of rest at home to recover from each episode. During his most recent febrile episode at 10 years of age, we prescribed 5.0 g of shinbuto (TJ-30;Tsumura Co., Tokyo, Japan). His fever resolved the next day and he was able to attend school. His growth and development are normal. Shinbuto had a therapeutic effect in this patient with PFAPA syndrome and may be useful in this condition.展开更多
文摘Background: The rubella outbreak in Japan has not yet been eliminated. In particular, an outbreak of congenital rubella syndrome has recently become a public health problem in Japan. The World Health Organization has set an elimination target of 2015 for measles in Japan. However, an outbreak of measles occurred in Japan between 2007 and 2008. Starting in April 2006, the measles and rubella vaccines were administered twice, once when a child reached 1 year old and once when the child was 5 - 6 years old (just before starting elementary school). Between October of 1978 and 2006, children were vaccinated only once for measles and rubella. Design: During the study enrollment period (2011-2013), the serum antibody titers of measles and rubella were measured in pediatric patients (n = 163) in the Tokyo Takanawa Hospital. Results: The prevalence rates of the two diseases indicated that only one vaccination was insufficient to protect against infection. Conclusions: Our studies have determined that it was important to vaccinate children twice for measles and rubella during early infancy.
文摘Background: The objective of this study is to determine whether analyze of the infant’s pain associated with diphtheria-pertussis-tetanus (DPT) immunization is useful for vaccination in children. It is not known whether the immunization pain can be prevented with the adequate choice of DPT vaccines among several manufacturers in Japan. Further, it is not clear whether the difference of the reaction during vaccination between gender and age. Design: Three manufacturer’s Japanese DPT vaccines were used in this study. The parents assessed their infant’s pain on a modified visual analogue scale (MVAS), the start of the crying and total crying time during the immunization. Results: The A manufacturer’s DPT vaccine was significantly lower on the proportion of crying, the duration of crying and MVAS score than the other two manufacturer’s DPT vaccines. The proportion of crying, the duration of crying and MVAS score was lower in the boy than in the girl. On the other hand, it had not found the difference of their reactions with age. Conclusions: Our studies have found that the adequate choice of DPT vaccine decreased vaccination pain. The studies also indicate that some tendencies with vaccinations were shown in children. To consider these tendencies was useful in performing less painful vaccination.
文摘Periodic fever with aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is an autoimmune disorder and the most common disorder characterized by periodic fever in children. A male patient has been followed up from 11 months to 10 years of age because of repeated high fever. We prescribed antifebriles and antibiotics for each febrile episode without a beneficial effect to him each time. He required several days of rest at home to recover from each episode. During his most recent febrile episode at 10 years of age, we prescribed 5.0 g of shinbuto (TJ-30;Tsumura Co., Tokyo, Japan). His fever resolved the next day and he was able to attend school. His growth and development are normal. Shinbuto had a therapeutic effect in this patient with PFAPA syndrome and may be useful in this condition.
