Shaoyang acupoints are the most frequently used in migraine treatment.However,the central analgesic mechanism remains poorly understood.Studies have demonstrated that single stimulus of the verum acupuncture in health...Shaoyang acupoints are the most frequently used in migraine treatment.However,the central analgesic mechanism remains poorly understood.Studies have demonstrated that single stimulus of the verum acupuncture in healthy subjects can induce significant connectivity or activity changes in painrelated central networks compared with sham acupuncture.However,these findings are not indicative of the central analgesic mechanism of acupuncture at Shaoyang acupoints.Thus,we recruited 100migraine sufferers and randomly assigned them into five groups:Shaoyang uncommon acupoint,Shaoyang common acupoint,Yangming uncommon acupoint,non-acupoint control,and blank control groups.Subjects were subjected to evaluation of curative effects and functional MRI prior to and after10 and 20 acupuncture treatments.All subjects were diagnosed by physicians and enrolled following clinical physical examination.Subjects were observed during 1–4 weeks after inclusion.At the fifth week,the first clinical evaluation and resting functional MRI were conducted.The Shaoyang uncommon acupoint,Shaoyang common acupoint,Yangming uncommon acupoint,and non-acupoint control grousp then were treated with acupuncture,five times per week,20 times in total over 4 weeks.The second and third clinical evaluations and resting functional MRI screenings were conducted following10 and 20 acupuncture treatments.The blank control group was observed during the 5 to 8 week period,followed by clinical evaluation and resting functional MRI.The aim of this study was to examine changes in brain functional activity and central networks in subjects with migraine undergoing acupuncture at Shaoyang uncommon acupoints.This study provides a further explanation of the central analgesic mechanism by which acupuncture at Shaoyang acupoints treats migraine.展开更多
Isobaric vapor–liquid equilibrium(VLE) data for the binary system ethyl propionate(2) + para-xylene(3) and ternary system ethanol(1) + ethyl propionate(2) + para-xylene(2) at atmospheric pressure(101.3 k Pa)were obta...Isobaric vapor–liquid equilibrium(VLE) data for the binary system ethyl propionate(2) + para-xylene(3) and ternary system ethanol(1) + ethyl propionate(2) + para-xylene(2) at atmospheric pressure(101.3 k Pa)were obtained by a VLE modified othmer still. All the experimental data passed a point to point consistency test of Van Ness method, which verified the data reliability. The Wilson and UNIQUAC activity coefficient models were employed to correlate the binary VLE data to obtain binary interaction parameters. Based on binary interaction parameters, ternary VLE data of ethanol(1) + ethyl propionate(2) + para-xylene(3) were predicted by Wilson and UNIQUAC models, which proved that predicted values are consistent with the experimental data.Furthermore, azeotropic phenomenon between ethanol and ethyl propionate disappears when the mole ratio of para-xylene and binary system of ethanol and ethyl propionate is 1:1. Therefore, this paper convinced that para-xylene is a proper extractive additive that could be used in extractive distillation to separate the binary azeotropic system of ethanol and ethyl propionate.展开更多
The influence of different coating formulas and times on the water and oil resistance of paperboard was studied. The water and oil resistance of paperboard coated with a modified butadiene-styrene copolymer latex and ...The influence of different coating formulas and times on the water and oil resistance of paperboard was studied. The water and oil resistance of paperboard coated with a modified butadiene-styrene copolymer latex and fluorinated anion grease-proof agent was better than that coated with modified butadiene-styrene copolymer latex,where the modified butadiene-styrene copolymer latex was used as the pre-coating substrate and the F1516 fluorinated grease-proof agent was used as the top coating material. By coating modified butadiene-styrene copolymer latex with 30% solid content and F1516 fluorinated grease-proof agent with 24% solid content,the oil resistance of paperboard could reach anti-oil grade 12 and the water resistance could increased by98. 64%( compared with the base paperboard without any coating treatment).展开更多
Houttuynia cordata flavonoid and Sophora japonica L. polysaccharide were investigated to develop anti-UV sun-screening agent through UV wavelength scanning spectrum, antioxidant ability and cell viability after UVB ir...Houttuynia cordata flavonoid and Sophora japonica L. polysaccharide were investigated to develop anti-UV sun-screening agent through UV wavelength scanning spectrum, antioxidant ability and cell viability after UVB irradiation. The results showed that the extracts had strong UVA and UVB absorption ability and hydroxyl free radical scavenging ability. The S. japonica L. polysaccharide showed strong anti-UVB irradiation ability according to the cell viability experiment. It suggests that the H. cordata flavonoid and S. japonica L. polysaccharide could be combined as a candidate of anti-UV sun-screening supplement and compensate for the shortcomings of chemical sunscreens against UVA ray.展开更多
The dietary fiber in oats is mainly concentrated in the bran;however,the oat bran is mostly used for livestock and poultry feed and thus has a low utilization rate and low added value.In this study,insoluble dietary f...The dietary fiber in oats is mainly concentrated in the bran;however,the oat bran is mostly used for livestock and poultry feed and thus has a low utilization rate and low added value.In this study,insoluble dietary fiber(IDF)was extracted by a combination ofα-amylase and neutral protease.The optimal extraction conditions of the IDF were obtained by response surface methodology.The material-to-water ratio was 1:12.1,the concentration ofα-amylase was 1.85%,and the hydrolysis time was 39.14 min.After purifying the crude fiber with 4%sodium oxide(Na OH),70°C hot water,and anhydrous ethanol,the purity of dietary fiber exceeded 95%.X-ray diffraction analysis indicated that the IDF was predominantly amorphous.Scanning electron microscopy showed that the IDF surface exhibited a loose porous network structure.Fourier-transform infrared spectroscopy of the crude IDF showed characteristic absorption peaks at 3626,2929,1667,1538,1455,1242,and1048 cm^(-1),while the infrared spectrum of the purified IDF showed characteristic absorption peaks at 3401,2924,1744,1643,1418,and 1040 cm^(-1),which is consistent with the structure of cellulose polysaccharide.Differential scanning calorimetry analysis showed that there were three exothermic peaks at 270–310°C,320–350°C,and 440–460°C,which may represent the pyrolysis peaks of hemicellulose,cellulose,and lignin,respectively,indicating that the oat bran IDF had good thermal stability.The results indicate that the oat bran IDF can be used for the production of dietary fiber products and health-care products.展开更多
Excessive exudate at wound sites increases treatment difficulty and severely decelerates the healing process.In wound exu-date management,dressings with unidirectional liquid transport capability have exhibited enormo...Excessive exudate at wound sites increases treatment difficulty and severely decelerates the healing process.In wound exu-date management,dressings with unidirectional liquid transport capability have exhibited enormous potential.However,it remains challenging to improve the one-way liquid transport efficiency.Herein,a trilayered fibrous dressing is constructed by sequentially electrospinning polyurethane(PU)and polyvinylidene fluoride(PVDF)onto cotton fabric.Through hot pressing,a stable wettability gradient is formed across the PVDF/PU/cotton dressing due to the melting and bridging of PU nanofib-ers.The trilayered dressing exhibited rapid unidirectional transport with water penetrating from the hydrophobic side to the hydrophilic side in 6 s.The hydrostatic pressure from the hydrophilic side to the hydrophobic side is 569%higher than that from the hydrophobic side to the hydrophilic side,indicating that the dressing has a profound unidirectional conductivity.In vivo experiments demonstrates that the trilayered dressing can accelerate the wound healing process,especially in the early stages of wound occurrence,by quickly draining the excessive exudate.This study provides a new method to construct wound dressings with wettability gradients,which are advantageous for efficient exudate removal.展开更多
Photodynamic antibacterial therapy(PDAT)is a kind of rejuvenating strategy that combats bacterial infection due to its admirable characteristics of noninvasiveness and broad-spectrum antibacterial capability.However,t...Photodynamic antibacterial therapy(PDAT)is a kind of rejuvenating strategy that combats bacterial infection due to its admirable characteristics of noninvasiveness and broad-spectrum antibacterial capability.However,the efficiency of PDAT can be greatly hindered by limited light irradiation.Herein,we propose an enhanced PDAT by employing photonic composite films(PCFs)via slow photon and multiple scattering effects.The PCFs are obtained by UV light-initiated polymerization of poly(ethylene glycol)phenyl ether acrylate with a self-assembled SiO_(2)colloidal particle array,followed by the deposition of photosensitizers(PSs).The PCFs can prompt the PSs with matched absorption,which are deposited on their surface,to sufficiently utilize the incident light and generate more reactive oxygen species based on the slow photon phenomenon of photonic crystals and multiple scattering effects of the SiO_(2)colloidal particles.This finding demonstrates the great potential and significance of PCFs in the field of PDAT,which may reduce the requirements of excitation equipment and avoid damage to normal tissues from exposure to huge light energy.展开更多
Wound management is a crucial measure for skin wound healing and is significantly important to maintaining the integrity of skins and their functions.Electrical stimulation at the wound site is a compelling strategy f...Wound management is a crucial measure for skin wound healing and is significantly important to maintaining the integrity of skins and their functions.Electrical stimulation at the wound site is a compelling strategy for skin wound repair.However,there has been an urgent need for wearable and point-of-care electrical stimulation devices that have self-adhesive and mechanical properties comparable to wound tissue.Herein,we develop a bioinspired hybrid patch with self-adhesive and piezoelectric nanogenerator(HPSP)for promoting skin wound healing,which is composed of a mussel-inspired hydrogel matrix and a piezoelectric nanogenerator based on aligned electrospun poly(vinylidene fluoride)nanofibers.The device with optimized modulus and permeability for skin wear can self-adhere to the wound site and locally produce a dynamic voltage caused by motion.We show that the HPSP not only promotes fibroblast proliferation and migration in vitro,but also effectively facilitates the collagen deposition,angiogenesis,and re-epithelialization in vivo with the increased expressions of crucial growth factors.The HPSP reduces the wound closure time of full-thickness skin defects by about 1/3,greatly accelerating the healing process.This patch can serve as wearable and real-time electrical stimulation devices,potentially useful in clinical applications of skin wound healing.展开更多
Utilizing photothermal hydrogels as a wound dressing is a promising strategy to accelerate wound healing.Usually,a photothermal hydrogel has a strong light-absorbing capability,and hence its transparency can be largel...Utilizing photothermal hydrogels as a wound dressing is a promising strategy to accelerate wound healing.Usually,a photothermal hydrogel has a strong light-absorbing capability,and hence its transparency can be largely sacrificed,which is unbeneficial for the visual monitoring of wound states.It remains challenging to balance the trade-off between the photothermal conversion and wound visualization for the photothermal hydrogel dressing.Herein,a composite photothermal hydrogel film with high transparency is presented for the visual monitor of the wound,which is constructed by incorporating CsxW03 nanorods into the networks of polyacrylamide hydrogels.The composite photothermal hydrogel film exhibits high light absorption in the near-infrared region and high transmittance in the visible light region.Under 980 nm laser irradiation,the composite hydrogel can be heated up to 45°C.In vivo animal experiment on mouse skin wound model shows that the composite hydrogel film can locally heat the skin wound to accelerate healing while maintaining more than 70%transparency to realize real-time observation of the wound.This study provides the first attempt to solve the problem of opacity in photothermal hydrogel dressings,promoting the possibility of its clinical applications.展开更多
基金supported by the National Basic Research Program of China(973 Program),No.2012CB518501the Key Project of the National Natural Science Foundation of China,No.30930112/C190301
文摘Shaoyang acupoints are the most frequently used in migraine treatment.However,the central analgesic mechanism remains poorly understood.Studies have demonstrated that single stimulus of the verum acupuncture in healthy subjects can induce significant connectivity or activity changes in painrelated central networks compared with sham acupuncture.However,these findings are not indicative of the central analgesic mechanism of acupuncture at Shaoyang acupoints.Thus,we recruited 100migraine sufferers and randomly assigned them into five groups:Shaoyang uncommon acupoint,Shaoyang common acupoint,Yangming uncommon acupoint,non-acupoint control,and blank control groups.Subjects were subjected to evaluation of curative effects and functional MRI prior to and after10 and 20 acupuncture treatments.All subjects were diagnosed by physicians and enrolled following clinical physical examination.Subjects were observed during 1–4 weeks after inclusion.At the fifth week,the first clinical evaluation and resting functional MRI were conducted.The Shaoyang uncommon acupoint,Shaoyang common acupoint,Yangming uncommon acupoint,and non-acupoint control grousp then were treated with acupuncture,five times per week,20 times in total over 4 weeks.The second and third clinical evaluations and resting functional MRI screenings were conducted following10 and 20 acupuncture treatments.The blank control group was observed during the 5 to 8 week period,followed by clinical evaluation and resting functional MRI.The aim of this study was to examine changes in brain functional activity and central networks in subjects with migraine undergoing acupuncture at Shaoyang uncommon acupoints.This study provides a further explanation of the central analgesic mechanism by which acupuncture at Shaoyang acupoints treats migraine.
基金Supported by the National Natural Science Foundation of China(21376166)
文摘Isobaric vapor–liquid equilibrium(VLE) data for the binary system ethyl propionate(2) + para-xylene(3) and ternary system ethanol(1) + ethyl propionate(2) + para-xylene(2) at atmospheric pressure(101.3 k Pa)were obtained by a VLE modified othmer still. All the experimental data passed a point to point consistency test of Van Ness method, which verified the data reliability. The Wilson and UNIQUAC activity coefficient models were employed to correlate the binary VLE data to obtain binary interaction parameters. Based on binary interaction parameters, ternary VLE data of ethanol(1) + ethyl propionate(2) + para-xylene(3) were predicted by Wilson and UNIQUAC models, which proved that predicted values are consistent with the experimental data.Furthermore, azeotropic phenomenon between ethanol and ethyl propionate disappears when the mole ratio of para-xylene and binary system of ethanol and ethyl propionate is 1:1. Therefore, this paper convinced that para-xylene is a proper extractive additive that could be used in extractive distillation to separate the binary azeotropic system of ethanol and ethyl propionate.
文摘The influence of different coating formulas and times on the water and oil resistance of paperboard was studied. The water and oil resistance of paperboard coated with a modified butadiene-styrene copolymer latex and fluorinated anion grease-proof agent was better than that coated with modified butadiene-styrene copolymer latex,where the modified butadiene-styrene copolymer latex was used as the pre-coating substrate and the F1516 fluorinated grease-proof agent was used as the top coating material. By coating modified butadiene-styrene copolymer latex with 30% solid content and F1516 fluorinated grease-proof agent with 24% solid content,the oil resistance of paperboard could reach anti-oil grade 12 and the water resistance could increased by98. 64%( compared with the base paperboard without any coating treatment).
基金Supported by College Students'Practice Innovation Training Project in Henan Province(No.201711834006)Henan Provincial Department of Education(No.15A350008)
文摘Houttuynia cordata flavonoid and Sophora japonica L. polysaccharide were investigated to develop anti-UV sun-screening agent through UV wavelength scanning spectrum, antioxidant ability and cell viability after UVB irradiation. The results showed that the extracts had strong UVA and UVB absorption ability and hydroxyl free radical scavenging ability. The S. japonica L. polysaccharide showed strong anti-UVB irradiation ability according to the cell viability experiment. It suggests that the H. cordata flavonoid and S. japonica L. polysaccharide could be combined as a candidate of anti-UV sun-screening supplement and compensate for the shortcomings of chemical sunscreens against UVA ray.
基金supported by the Natural Science Foundation of Tianjin,China(No.17JCYBJC20400)。
文摘The dietary fiber in oats is mainly concentrated in the bran;however,the oat bran is mostly used for livestock and poultry feed and thus has a low utilization rate and low added value.In this study,insoluble dietary fiber(IDF)was extracted by a combination ofα-amylase and neutral protease.The optimal extraction conditions of the IDF were obtained by response surface methodology.The material-to-water ratio was 1:12.1,the concentration ofα-amylase was 1.85%,and the hydrolysis time was 39.14 min.After purifying the crude fiber with 4%sodium oxide(Na OH),70°C hot water,and anhydrous ethanol,the purity of dietary fiber exceeded 95%.X-ray diffraction analysis indicated that the IDF was predominantly amorphous.Scanning electron microscopy showed that the IDF surface exhibited a loose porous network structure.Fourier-transform infrared spectroscopy of the crude IDF showed characteristic absorption peaks at 3626,2929,1667,1538,1455,1242,and1048 cm^(-1),while the infrared spectrum of the purified IDF showed characteristic absorption peaks at 3401,2924,1744,1643,1418,and 1040 cm^(-1),which is consistent with the structure of cellulose polysaccharide.Differential scanning calorimetry analysis showed that there were three exothermic peaks at 270–310°C,320–350°C,and 440–460°C,which may represent the pyrolysis peaks of hemicellulose,cellulose,and lignin,respectively,indicating that the oat bran IDF had good thermal stability.The results indicate that the oat bran IDF can be used for the production of dietary fiber products and health-care products.
基金supported by a grant from the National Natural Science Foundation of China(51973195)Zhejiang Provincial Key Research and Development Program(2020C03042)“Ten Thousand Plan”-Zhejiang Provincial High Level Talents Special Support Plan(2020R52023).
文摘Excessive exudate at wound sites increases treatment difficulty and severely decelerates the healing process.In wound exu-date management,dressings with unidirectional liquid transport capability have exhibited enormous potential.However,it remains challenging to improve the one-way liquid transport efficiency.Herein,a trilayered fibrous dressing is constructed by sequentially electrospinning polyurethane(PU)and polyvinylidene fluoride(PVDF)onto cotton fabric.Through hot pressing,a stable wettability gradient is formed across the PVDF/PU/cotton dressing due to the melting and bridging of PU nanofib-ers.The trilayered dressing exhibited rapid unidirectional transport with water penetrating from the hydrophobic side to the hydrophilic side in 6 s.The hydrostatic pressure from the hydrophilic side to the hydrophobic side is 569%higher than that from the hydrophobic side to the hydrophilic side,indicating that the dressing has a profound unidirectional conductivity.In vivo experiments demonstrates that the trilayered dressing can accelerate the wound healing process,especially in the early stages of wound occurrence,by quickly draining the excessive exudate.This study provides a new method to construct wound dressings with wettability gradients,which are advantageous for efficient exudate removal.
基金This work was supported by the National Natural Science Foundation of China(52022032).
文摘Photodynamic antibacterial therapy(PDAT)is a kind of rejuvenating strategy that combats bacterial infection due to its admirable characteristics of noninvasiveness and broad-spectrum antibacterial capability.However,the efficiency of PDAT can be greatly hindered by limited light irradiation.Herein,we propose an enhanced PDAT by employing photonic composite films(PCFs)via slow photon and multiple scattering effects.The PCFs are obtained by UV light-initiated polymerization of poly(ethylene glycol)phenyl ether acrylate with a self-assembled SiO_(2)colloidal particle array,followed by the deposition of photosensitizers(PSs).The PCFs can prompt the PSs with matched absorption,which are deposited on their surface,to sufficiently utilize the incident light and generate more reactive oxygen species based on the slow photon phenomenon of photonic crystals and multiple scattering effects of the SiO_(2)colloidal particles.This finding demonstrates the great potential and significance of PCFs in the field of PDAT,which may reduce the requirements of excitation equipment and avoid damage to normal tissues from exposure to huge light energy.
基金We thank the funding support from the National Natural Science Foundation of China(Nos.51973075 and 51525302)Program for HUST Academic Frontier Youth Team(2015-01)The authors thank HUST Analytical and Testing Center for their supports on the facilities.
文摘Wound management is a crucial measure for skin wound healing and is significantly important to maintaining the integrity of skins and their functions.Electrical stimulation at the wound site is a compelling strategy for skin wound repair.However,there has been an urgent need for wearable and point-of-care electrical stimulation devices that have self-adhesive and mechanical properties comparable to wound tissue.Herein,we develop a bioinspired hybrid patch with self-adhesive and piezoelectric nanogenerator(HPSP)for promoting skin wound healing,which is composed of a mussel-inspired hydrogel matrix and a piezoelectric nanogenerator based on aligned electrospun poly(vinylidene fluoride)nanofibers.The device with optimized modulus and permeability for skin wear can self-adhere to the wound site and locally produce a dynamic voltage caused by motion.We show that the HPSP not only promotes fibroblast proliferation and migration in vitro,but also effectively facilitates the collagen deposition,angiogenesis,and re-epithelialization in vivo with the increased expressions of crucial growth factors.The HPSP reduces the wound closure time of full-thickness skin defects by about 1/3,greatly accelerating the healing process.This patch can serve as wearable and real-time electrical stimulation devices,potentially useful in clinical applications of skin wound healing.
基金The authors are thankful to the HUST Analytical and Testing Center for their help with the facilities.We thank the funding support from the National Natural Science Foundation of China(Grant No.52022032).
文摘Utilizing photothermal hydrogels as a wound dressing is a promising strategy to accelerate wound healing.Usually,a photothermal hydrogel has a strong light-absorbing capability,and hence its transparency can be largely sacrificed,which is unbeneficial for the visual monitoring of wound states.It remains challenging to balance the trade-off between the photothermal conversion and wound visualization for the photothermal hydrogel dressing.Herein,a composite photothermal hydrogel film with high transparency is presented for the visual monitor of the wound,which is constructed by incorporating CsxW03 nanorods into the networks of polyacrylamide hydrogels.The composite photothermal hydrogel film exhibits high light absorption in the near-infrared region and high transmittance in the visible light region.Under 980 nm laser irradiation,the composite hydrogel can be heated up to 45°C.In vivo animal experiment on mouse skin wound model shows that the composite hydrogel film can locally heat the skin wound to accelerate healing while maintaining more than 70%transparency to realize real-time observation of the wound.This study provides the first attempt to solve the problem of opacity in photothermal hydrogel dressings,promoting the possibility of its clinical applications.