囊腔型肺癌(lung cancer associated with cystic airspaces,LCCA)是一种影像学上表现为肿瘤内或边缘存在囊性空腔的肺癌类型。由于易被误诊或漏诊,LCCA患者的预后不良,因此需要更多临床研究来揭示其特点。目前已有4种影像学分类系统,...囊腔型肺癌(lung cancer associated with cystic airspaces,LCCA)是一种影像学上表现为肿瘤内或边缘存在囊性空腔的肺癌类型。由于易被误诊或漏诊,LCCA患者的预后不良,因此需要更多临床研究来揭示其特点。目前已有4种影像学分类系统,并且近年来对LCCA的关注度逐渐升高,尤其是对其影像学特征进行了一定的研究。既往结果显示,LCCA的病理特征与影像学表现存在相关性,但对于与肺癌相关的驱动基因突变和分子分型的研究仍不充分。由于LCCA难以早期诊断,预后较一般类型肺癌差,本文综述了LCCA的定义、病因与发病机制、影像学特征与诊断依据、组织学和病理学特征及预后等方面的研究进展,以期为临床决策提供参考。展开更多
In pressurized water reactor(PWR),fretting wear is one of the main causes of fuel assembly failure.Moreover,the operation condition of cladding is complex and harsh.A unique fretting damage test equipment was develope...In pressurized water reactor(PWR),fretting wear is one of the main causes of fuel assembly failure.Moreover,the operation condition of cladding is complex and harsh.A unique fretting damage test equipment was developed and tested to simulate the fretting damage evolution process of cladding in the PWR environment.It can simulate the fretting wear experiment of PWR under different temperatures(maximum temperature is 350℃),displacement amplitude,vibration frequency,and normal force.The fretting wear behavior of Zr-4 alloy under different temperature environments was tested.In addition,the evolution of wear scar morphology,profile,and wear volume was studied using an optical microscope(OM),scanning electron microscopy(SEM),and a 3D white light interferometer.Results show that higher water temperature evidently decreased the cladding wear volume,the wear mechanism of Zr-4 cladding changed from abrasive wear to adhesive wear and the formation of an oxide layer on the wear scar reduced the wear volume and maximum wear depth.展开更多
In this work,the medium internal phase O/W Pickering emulsions stabilized with bamboo shoots nanocellulose(BSNC)was successfully fabricated.The nanocellulose extracted from bamboo shoots with an average width of 56.37...In this work,the medium internal phase O/W Pickering emulsions stabilized with bamboo shoots nanocellulose(BSNC)was successfully fabricated.The nanocellulose extracted from bamboo shoots with an average width of 56.37 nm and height of 7.44 nm showed great potential as an emulsifier in the Pickering emulsions.The effects of BSNC content,oil-water ratio and emulsification process on the structure,stability and rheology of the resultant Pickering emulsions was explored.The obtained emulsion with the BSNC content of 0.5 wt%at the oil to water volume ratio of 5:5 had a lower particle size of around 25μm.With the increasing BSNC content,the emulsions presented increased droplet size,and even demulsification occurred.Interestingly,the physicochemical properties of the emulsions could be significantly improved through twice shearing,which effectively reduced droplet size.The surface coverage was above 100%for the Pickering emulsions stabilized with the BSNC content of 0.5%-1.1%.With the increasing BSNC content,the apparent viscosity was increased first and then decreased,and all emulsions showed elastic behaviors.This work would provide theoretical guidance for preparing medium or high internal phase Pickering emulsions stabilized with nanocellulose.展开更多
基金国家自然科学基金项目(No.82360562、No.82272980、No.82060426、No.81702274)云南省基础研究计划项目(No.202201 AY 070001-133)云南省科技厅基础研究专项(No.202201AT070011)资助。
文摘囊腔型肺癌(lung cancer associated with cystic airspaces,LCCA)是一种影像学上表现为肿瘤内或边缘存在囊性空腔的肺癌类型。由于易被误诊或漏诊,LCCA患者的预后不良,因此需要更多临床研究来揭示其特点。目前已有4种影像学分类系统,并且近年来对LCCA的关注度逐渐升高,尤其是对其影像学特征进行了一定的研究。既往结果显示,LCCA的病理特征与影像学表现存在相关性,但对于与肺癌相关的驱动基因突变和分子分型的研究仍不充分。由于LCCA难以早期诊断,预后较一般类型肺癌差,本文综述了LCCA的定义、病因与发病机制、影像学特征与诊断依据、组织学和病理学特征及预后等方面的研究进展,以期为临床决策提供参考。
基金Supported by National Key R&D Program of China(Grant No.2022YFB3401901)Key Program of National Natural Science Foundation of China(Grant No.U2067221)+2 种基金Sichuan Provincial Science and Technology Planning Project(Grant Nos.2022JDJQ0019 and 2022ZYD0029)Funds for China Postdoctoral Science Foundation(Grant No.2022M713008)Sichuan Provincial Innovative Talent Funding Project for Postdoctoral Fellows(Grant No.BX202225).
文摘In pressurized water reactor(PWR),fretting wear is one of the main causes of fuel assembly failure.Moreover,the operation condition of cladding is complex and harsh.A unique fretting damage test equipment was developed and tested to simulate the fretting damage evolution process of cladding in the PWR environment.It can simulate the fretting wear experiment of PWR under different temperatures(maximum temperature is 350℃),displacement amplitude,vibration frequency,and normal force.The fretting wear behavior of Zr-4 alloy under different temperature environments was tested.In addition,the evolution of wear scar morphology,profile,and wear volume was studied using an optical microscope(OM),scanning electron microscopy(SEM),and a 3D white light interferometer.Results show that higher water temperature evidently decreased the cladding wear volume,the wear mechanism of Zr-4 cladding changed from abrasive wear to adhesive wear and the formation of an oxide layer on the wear scar reduced the wear volume and maximum wear depth.
基金This work was supported by the National Nature Science Foundation of China(32072177).
文摘In this work,the medium internal phase O/W Pickering emulsions stabilized with bamboo shoots nanocellulose(BSNC)was successfully fabricated.The nanocellulose extracted from bamboo shoots with an average width of 56.37 nm and height of 7.44 nm showed great potential as an emulsifier in the Pickering emulsions.The effects of BSNC content,oil-water ratio and emulsification process on the structure,stability and rheology of the resultant Pickering emulsions was explored.The obtained emulsion with the BSNC content of 0.5 wt%at the oil to water volume ratio of 5:5 had a lower particle size of around 25μm.With the increasing BSNC content,the emulsions presented increased droplet size,and even demulsification occurred.Interestingly,the physicochemical properties of the emulsions could be significantly improved through twice shearing,which effectively reduced droplet size.The surface coverage was above 100%for the Pickering emulsions stabilized with the BSNC content of 0.5%-1.1%.With the increasing BSNC content,the apparent viscosity was increased first and then decreased,and all emulsions showed elastic behaviors.This work would provide theoretical guidance for preparing medium or high internal phase Pickering emulsions stabilized with nanocellulose.