Preparation and evaluation of controllable drug delivery system:A light responsive nanosphere based on β-cyclodextrin/mesoporous silica

A novel light responsive nanosphere was constructed,and it was used as a drug carrier to investigate the loading and release properties of the Quercetin(QU).In this paper,mesoporous silica nanoparticles(MSN)were used as a substrate,and 3-aminopropyl triethyoxysilane was used as a surface modification agent to introduce—NH_(2),and the azobenzene-4,4’-dicarboxylic acid(AZO)was used as light responsive agent to introduce the group of—N=N—,and thenβ-cyclodextrin(β-CD)was combined with AZO through host-guest interaction to construct light responsive nanoparticles(MSN@β-CD).The structure and properties of the carrier were analyzed by FTIR,BET,XPS,TGA,XRD,SEM and TEM.In vitro drug release studies showed the release rate of QU@MSN@β-CD(dark)was 12.19%within 72 h,but the release rate of QU@MSN@β-CD(light 10 min)was 26.09%,exhibiting a light-responsive property.The CCK8 tests demonstrated that MSN@β-CD could significantly decrease the toxicity of QU.Therefore,the controllable light-responsive drug delivery system has great application prospects.

Perovskite-based color camera inspired by human visual cells

There are two primary types of photoreceptor cells in the human eye:cone cells and rod cells that enable color vision and night vision,respectively.Herein,inspired by the function of human visual cells,we develop a high-resolution perovskite-based color camera using a set of narrowband red,green,blue,and broadband white perovskite photodetectors as imaging sensors.The narrowband red,green,and blue perovskite photodetectors with color perceptions mimic long-,medium-,and short-wavelength cones cells to achieve color imaging ability.Also,the broadband white perovskite photodetector with better detectivity mimics rod cells to improve weak-light imaging ability.Our perovskite-based camera,combined with predesigned pattern illumination and image reconstruction technology,is demonstrated with high-resolution color images(up to 256 x 256 pixels)in diffuse mode.This is far beyond previously reported advanced perovskite array image sensors that only work in monochrome transmission mode.This work shows a new approach to bio-inspired cameras and their great potential to strongly mimic the ability of the natural eve.

Aerodynamic performance enhancement of co-flow jet airfoil with simple high-lift device

The present study performed a numerical investigation to explore the performance enhancement of a co-flow jet(CFJ)airfoil with simple high-lift device configuration,with a specific goal to examine the feasibility and capability of the proposed configuration for low-speed take-off and landing.Computations have been accomplished by an in-house-programmed Reynoldsaveraged Navier-Stokes solver enclosed by k-ωshear stress transport turbulence model.Three crucial geometric parameters,viz.,injection slot location,suction slot location and its angle were selected for the sake of revealing their effects on aerodynamic lift,drag,power consumption and equivalent lift-to-drag ratio.Results show that using simple high-lift devices on CFJ airfoil can significantly augment the aerodynamic associated lift and efficiency which evidences the feasibility of CFJ for short take-off and landing with small angle of attack.The injection and suction slot locations are more influential with respect to the aerodynamic performance of CFJ airfoil compared with the suction slot angle.The injection location is preferable to be located in the downstream of the pressure suction peak on leading edge to reduce the power expenditure of the pumping system for a relative higher equivalent lift-to-drag ratio.Another concluded criterion is that the suction slot should be oriented on the trailing edge flap for achieving more aerodynamic gain,meanwhile,carefully selecting this location is crucial in determining the aerodynamic enhancement of CFJ airfoil with deflected flaps.

Aerodynamic characteristics of co-flow jet wing with simple high-lift devices

Numerical investigations are conducted to explore the aerodynamic characteristics of three-dimensional Co-Flow Jet(CFJ) wing with simple high-lift devices during low-speed takeoff and landing. Effects of three crucial parameters of CFJ wing, i.e., angle of attack, jet momentum and swept angle, are comprehensively examined. Additionally, the aerodynamic characteristics of two CFJ configurations, i.e., using open and discrete slots for injection, are compared. The results show that applying CFJ technique to a wing with simple high-lift device is able to generate more lift,reduce drag and enlarge stall margin with lower energy expenditure due to the super-circulation effect. Increasing the jet intensity can reduce the drag significantly, which is mainly contributed by the reaction jet force. The Oswald efficiency factor is, in some circumstances, larger than one,which indicates the potential of CFJ in reducing induced drag. Compared with clean wing configuration, using CFJ technique allows the aerodynamic force variation less sensitive to the swept angle, and such phenomenon is better observed for small swept angle region. Eventually, it is interesting to know that the discrete slotted CFJ configuration demonstrates a promising enhancement in aerodynamic performance in terms of high lift, low drag and efficiency.