For high-dimensional models with a focus on classification performance,the?1-penalized logistic regression is becoming important and popular.However,the Lasso estimates could be problematic when penalties of different...For high-dimensional models with a focus on classification performance,the?1-penalized logistic regression is becoming important and popular.However,the Lasso estimates could be problematic when penalties of different coefficients are all the same and not related to the data.We propose two types of weighted Lasso estimates,depending upon covariates determined by the Mc Diarmid inequality.Given sample size n and a dimension of covariates p,the finite sample behavior of our proposed method with a diverging number of predictors is illustrated by non-asymptotic oracle inequalities such as the?1-estimation error and the squared prediction error of the unknown parameters.We compare the performance of our method with that of former weighted estimates on simulated data,then apply it to do real data analysis.展开更多
The hypoxia of the tumor microenvironment(TME)seriously restricts the photodynamic therapy(PDT)effect of conventional type-II photosensitizers,which are highly dependent on O_(2).In this work,a new type-I photosensiti...The hypoxia of the tumor microenvironment(TME)seriously restricts the photodynamic therapy(PDT)effect of conventional type-II photosensitizers,which are highly dependent on O_(2).In this work,a new type-I photosensitizer(TPE-TeVPPh3)consisting of a tetraphenylethylene group(TPE)as a bioimaging moiety,triphenyl-phosphine(PPh3)as a mitochondria-targeting group,and telluroviologen(TeV2+)as a reactive oxygen species(O_(2)•−,•OH)generating moiety is developed.The luminescence intensity of TPE-TeV-PPh3 increased significantly after specific oxidation by excess H2O2 in the TME without responding to normal tissues via the formation of Te═O bond,which can be used for monitoring abnormal H2O2,positioning,and imaging of tumors.TPE-TeV-PPh3 with highly reactive radicals generation and stronger hypoxia tolerance realizes efficient cancer cell killing under hypoxic conditions,achieving 88%tumor growth inhibition.Therefore,TPE-TeV-PPh3 with low phototoxicity in normal tissue achieves tumor imaging and effective PDT toward solid tumors in response to high concentrations of H_(2)O_(2)in the TME,which provides a new strategy for the development of type-I photosensitizers.展开更多
基金Supported by the National Natural Science Foundation of China(61877023)the Fundamental Research Funds for the Central Universities(CCNU19TD009)。
文摘For high-dimensional models with a focus on classification performance,the?1-penalized logistic regression is becoming important and popular.However,the Lasso estimates could be problematic when penalties of different coefficients are all the same and not related to the data.We propose two types of weighted Lasso estimates,depending upon covariates determined by the Mc Diarmid inequality.Given sample size n and a dimension of covariates p,the finite sample behavior of our proposed method with a diverging number of predictors is illustrated by non-asymptotic oracle inequalities such as the?1-estimation error and the squared prediction error of the unknown parameters.We compare the performance of our method with that of former weighted estimates on simulated data,then apply it to do real data analysis.
基金Natural Science Foundation of China,Grant/Award Numbers:22175138,21875180Key Research and Development Program of Shaanxi,Grant/Award Number:2021GXLH-Z023Independent Innovation Capability Improvement Project of Xi’an Jiaotong University,Grant/Award Number:PY3A066。
文摘The hypoxia of the tumor microenvironment(TME)seriously restricts the photodynamic therapy(PDT)effect of conventional type-II photosensitizers,which are highly dependent on O_(2).In this work,a new type-I photosensitizer(TPE-TeVPPh3)consisting of a tetraphenylethylene group(TPE)as a bioimaging moiety,triphenyl-phosphine(PPh3)as a mitochondria-targeting group,and telluroviologen(TeV2+)as a reactive oxygen species(O_(2)•−,•OH)generating moiety is developed.The luminescence intensity of TPE-TeV-PPh3 increased significantly after specific oxidation by excess H2O2 in the TME without responding to normal tissues via the formation of Te═O bond,which can be used for monitoring abnormal H2O2,positioning,and imaging of tumors.TPE-TeV-PPh3 with highly reactive radicals generation and stronger hypoxia tolerance realizes efficient cancer cell killing under hypoxic conditions,achieving 88%tumor growth inhibition.Therefore,TPE-TeV-PPh3 with low phototoxicity in normal tissue achieves tumor imaging and effective PDT toward solid tumors in response to high concentrations of H_(2)O_(2)in the TME,which provides a new strategy for the development of type-I photosensitizers.
