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RET融合型非小细胞肺癌的研究进展 被引量:5
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作者 郑玉军 姜巍 +4 位作者 陈东妍 李颜君 代璐璐 黄磊 王明吉 《中国肺癌杂志》 CAS CSCD 北大核心 2021年第8期591-597,共7页
过去的20年来,随着分子生物学研究的不断进展,非小细胞肺癌(non-small cell lung cancer,NSCLC)的治疗方法不断发展,靶向治疗使驱动基因突变阳性患者的生存期得到了改善。越来越多的靶点逐渐被发现,针对不同驱动基因的药物将NSCLC的治... 过去的20年来,随着分子生物学研究的不断进展,非小细胞肺癌(non-small cell lung cancer,NSCLC)的治疗方法不断发展,靶向治疗使驱动基因突变阳性患者的生存期得到了改善。越来越多的靶点逐渐被发现,针对不同驱动基因的药物将NSCLC的治疗带入了一个前景广阔的靶向时代。在NSCLC的诸多驱动基因中,转染原癌基因(transfection proto-oncogene gene,RET)融合是除了表皮生长因子受体(epidermal growth factor receptor,EGFR)、间变淋巴瘤激酶(anaplastic lymphoma kinase,ALK)及c-ros原癌基因1-受体酪氨酸激酶(c-ros oncogene 1,receptor tyrosine kinase,ROS1)以外又一个重要的新兴靶点,针对RET基因融合的靶向药物不断推陈出新,近来新型高选择性RET抑制剂BLU-667和LOXO-292获得了重要突破。本文将对NSCLC中RET基因融合突变的概述、检测方法、临床病理特征、靶向治疗及耐药后的研究进展进行综述。 展开更多
关键词 肺肿瘤 转染原癌基因 融合基因
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外泌体在恶性肿瘤中的研究进展 被引量:2
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作者 郑玉军 姜巍 +5 位作者 陈东妍 王雷 李颜君 代璐璐 黄磊 王明吉 《中国肺癌杂志》 CAS CSCD 北大核心 2020年第8期689-694,共6页
"体液活检"是近些年恶性肿瘤研究的热点,肿瘤细胞外泌体因携带其"母体"肿瘤细胞的部分功能性蛋白及基因,介导信息传递、参与调控机体的生理功能及病理状态在肿瘤的发生发展过程中起着重要作用,并作为肿瘤液态活检... "体液活检"是近些年恶性肿瘤研究的热点,肿瘤细胞外泌体因携带其"母体"肿瘤细胞的部分功能性蛋白及基因,介导信息传递、参与调控机体的生理功能及病理状态在肿瘤的发生发展过程中起着重要作用,并作为肿瘤液态活检的一种新途径。本文旨在对外泌体的结构、生物特性和检测方法在恶性肿瘤发生发展及临床诊断治疗中的作用进行综述。 展开更多
关键词 外泌体 恶性肿瘤 肿瘤发生
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免疫检查点抑制剂在EGFR突变型晚期非小细胞肺癌中的应用 被引量:2
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作者 郑玉军 姜巍 +5 位作者 李晶 代璐璐 陈东妍 李颜君 黄磊 王明吉 《中国肺癌杂志》 CAS CSCD 北大核心 2022年第9期671-677,共7页
近年来,免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)极大地提高了无驱动基因突变的非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的生存率。与野生型肿瘤相比,表皮生长因子受体(epidermal growth factor receptor,EGFR... 近年来,免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)极大地提高了无驱动基因突变的非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的生存率。与野生型肿瘤相比,表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的肿瘤在程序性细胞死亡配体1(programmed cell death ligand 1,PD-L1)、肿瘤突变负荷(tumor mutational burden,TMB)等免疫微环境特征上具有更大的异质性。ICIs是否适用于EGFR突变的NSCLC患者一直存在争议。临床研究显示免疫单药对于EGFR突变的NSCLC患者无显著疗效,ICIs联合化疗和抗血管生成药物则显示了良好的生存获益。本文就EGFR突变晚期NSCLC患者ICIs单药或联合治疗的临床研究及相关机制进行综述。 展开更多
关键词 分子特征 免疫检查点抑制剂 肺肿瘤
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Optimization of Air Defense System Deployment Against Reconnaissance Drone Swarms 被引量:1
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作者 Ning Li zhenglian Su +2 位作者 Haifeng Ling Mumtaz Karatas yujun zheng 《Complex System Modeling and Simulation》 2023年第2期102-117,共16页
Due to their advantages in flexibility,scalability,survivability,and cost-effectiveness,drone swarms have been increasingly used for reconnaissance tasks and have posed great challenges to their opponents on modern ba... Due to their advantages in flexibility,scalability,survivability,and cost-effectiveness,drone swarms have been increasingly used for reconnaissance tasks and have posed great challenges to their opponents on modern battlefields.This paper studies an optimization problem for deploying air defense systems against reconnaissance drone swarms.Given a set of available air defense systems,the problem determines the location of each air defense system in a predetermined region,such that the cost for enemy drones to pass through the region would be maximized.The cost is calculated based on a counterpart drone path planning problem.To solve this adversarial problem,we first propose an exact iterative search algorithm for small-size problem instances,and then propose an evolutionary framework that uses a specific encoding-decoding scheme for large-size problem instances.We implement the evolutionary framework with six popular evolutionary algorithms.Computational experiments on a set of different test instances validate the effectiveness of our approach for defending against reconnaissance drone swarms. 展开更多
关键词 drone swarms anti-drone air defense systems deployment optimization evolutionary algorithms
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UAV search-and-rescue planning using an adaptive memetic algorithm 被引量:2
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作者 Libin HONG Yue WANG +2 位作者 Yichen DU Xin CHEN yujun zheng 《Frontiers of Information Technology & Electronic Engineering》 SCIE EI CSCD 2021年第11期1477-1491,共15页
The use of unmanned aerial vehicles(UAVs) is becoming more commonplace in search-and-rescue tasks,but UAV search planning can be very complex due to limited response time, large search area, and multiple candidate sea... The use of unmanned aerial vehicles(UAVs) is becoming more commonplace in search-and-rescue tasks,but UAV search planning can be very complex due to limited response time, large search area, and multiple candidate search modes. In this paper, we present a UAV search planning problem where the search area is divided into a set of subareas and each subarea has a prior probability that the target is present in it. The problem aims to determine the search sequence of the subareas and the search mode for each subarea to maximize the probability of finding the target. We propose an adaptive memetic algorithm that combines a genetic algorithm with a set of local search procedures and dynamically determines which procedure to apply based on the past performance of the procedures measured in fitness improvement and diversity improvement during problem-solving. Computational experiments show that the proposed algorithm exhibits competitive performance compared to a set of state-of-the-art global search heuristics, non-adaptive memetic algorithms, and adaptive memetic algorithms on a wide set of problem instances. 展开更多
关键词 Memetic algorithm SELF-ADAPTIVE Unmanned aerial vehicle(UAV) Search-and-rescue
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