Poor oral health,indicated by tooth loss and periodontal disease,may be an important risk factor for various cancers.Prior studies have found inconsistent associations between tooth loss and several cancer types.Here,...Poor oral health,indicated by tooth loss and periodontal disease,may be an important risk factor for various cancers.Prior studies have found inconsistent associations between tooth loss and several cancer types.Here,we examined the relationship between tooth loss and incident cases of multiple cancers in the Linxian General Population Nutrition Intervention Trial cohort.In this large prospective cohort of over 29,000 participants,there were 3101,1701,626,327,348,and 179 incident esophageal,gastric cardia,gastric noncardia,liver,lung,and colorectal cancer cases,respectively,over 30 years of follow-up.Adjusted Cox proportional hazards regression models with time-varying covariates were used to estimate hazard ratios(HRs)and 95%confidence intervals(CIs)for the association between tooth loss and cancer outcomes during three time intervals:≤5 years(early),>5 and≤10 years(mid),>10 years(late).Tooth loss was assessed as quartiles of the number of lost teeth in excess of the loess-smoothed,age-specific median number of teeth lost.For esophageal cancer,the increase in risk associated with the highest quartile of tooth loss was 25%(95%CI:1.02,1.52)in the mid time interval,but the association weakened thereafter.For gastric cardia cancer,the increase in risk associated with the highest quartile of tooth loss was 1.34 in both the early(95%CI:1.06,1.71)and mid time intervals(95%CI:1.02,1.76),with no significant associations in the late interval.Gastric noncardia cancer was only associated with the second quartile of tooth loss in the late time interval(HR=1.54;95%CI:1.16,2.04).All associations between tooth loss and liver,lung,and colorectal cancers were null.Tooth loss was associated with risk of esophageal and gastric cancers in this updated analysis from the cohort.展开更多
The publisher regrets<Informed consent and publication ethics statement were not included in the published version of the following article that appeared in a previous issue of Journal of the National Cancer Center...The publisher regrets<Informed consent and publication ethics statement were not included in the published version of the following article that appeared in a previous issue of Journal of the National Cancer Center.Hence,the authors of the below article were contacted after publication to request an informed consent and a publication ethics statement and have responded with the two by the time this erratum is being published.展开更多
文摘Poor oral health,indicated by tooth loss and periodontal disease,may be an important risk factor for various cancers.Prior studies have found inconsistent associations between tooth loss and several cancer types.Here,we examined the relationship between tooth loss and incident cases of multiple cancers in the Linxian General Population Nutrition Intervention Trial cohort.In this large prospective cohort of over 29,000 participants,there were 3101,1701,626,327,348,and 179 incident esophageal,gastric cardia,gastric noncardia,liver,lung,and colorectal cancer cases,respectively,over 30 years of follow-up.Adjusted Cox proportional hazards regression models with time-varying covariates were used to estimate hazard ratios(HRs)and 95%confidence intervals(CIs)for the association between tooth loss and cancer outcomes during three time intervals:≤5 years(early),>5 and≤10 years(mid),>10 years(late).Tooth loss was assessed as quartiles of the number of lost teeth in excess of the loess-smoothed,age-specific median number of teeth lost.For esophageal cancer,the increase in risk associated with the highest quartile of tooth loss was 25%(95%CI:1.02,1.52)in the mid time interval,but the association weakened thereafter.For gastric cardia cancer,the increase in risk associated with the highest quartile of tooth loss was 1.34 in both the early(95%CI:1.06,1.71)and mid time intervals(95%CI:1.02,1.76),with no significant associations in the late interval.Gastric noncardia cancer was only associated with the second quartile of tooth loss in the late time interval(HR=1.54;95%CI:1.16,2.04).All associations between tooth loss and liver,lung,and colorectal cancers were null.Tooth loss was associated with risk of esophageal and gastric cancers in this updated analysis from the cohort.
文摘The publisher regrets<Informed consent and publication ethics statement were not included in the published version of the following article that appeared in a previous issue of Journal of the National Cancer Center.Hence,the authors of the below article were contacted after publication to request an informed consent and a publication ethics statement and have responded with the two by the time this erratum is being published.
