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Photoimmunotherapy for Local Recurrence of Nasopharyngeal Carcinoma: A Case Report
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作者 yukiomi kushihashi Tatsuo Masubuchi +5 位作者 Isaku Okamoto Chihiro Fushimi Kenji Hanyu Mayu Yamauchi Yuichiro Tada Koki Miura 《International Journal of Otolaryngology and Head & Neck Surgery》 2022年第5期258-265,共8页
Photoimmunotherapy (PIT), developed by the National Cancer Institute, involves Cetuximab sarotalocan sodium infusion followed by laser irradiation. PIT exerts specific antitumor effects on a variety of carcinomas that... Photoimmunotherapy (PIT), developed by the National Cancer Institute, involves Cetuximab sarotalocan sodium infusion followed by laser irradiation. PIT exerts specific antitumor effects on a variety of carcinomas that express epidermal growth factor receptors. PIT is a new cancer treatment option approved by Japan ahead of other countries worldwide. As of 2022, PIT is indicated in “unresectable, locally advanced, or locally recurrent head and neck cancer, with priority given to standard treatments such as chemotherapy when available”. The conventional treatment for unresectable locally advanced or locally recurrent head and neck cancer is palliative. Whether photoimmunotherapy can be curative for unresectable locally advanced head and neck cancers depends on the case. Herein, we report a case of locally recurrent nasopharyngeal carcinoma, treated with photoimmunotherapy via the nasal cavity, along with a literature review. Preoperative simulation provided considerable information on device selection, numbers of devices, and availability of working space. As a result, a complete response was obtained following a cylindrical diffuser puncture. Cases of local recurrence of nasopharyngeal carcinoma are considered a good indication for PIT. However, since the follow-up period after treatment was short in this case, we will continue to conduct strict follow-ups and accumulate more cases. 展开更多
关键词 Photoimmunotherapy Nasopharyngeal Carcinoma Head and Neck Carcinoma Cetuximab Sarotalocan Sodium
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Association between head-and-neck cancers and active and passive cigarette smoking 被引量:1
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作者 yukiomi kushihashi Yoshiyuki Kadokura +5 位作者 Syuhei Takiguchi Yoshiyuki Kyo Yoshihiro Yamada Miki Shino Masato Kano Harumi Suzaki 《Health》 2012年第9期619-624,共6页
Although there have been many reports on the toxicity of tobacco smoke, fewer studies have reported the relationship between the smoke and carcinogenesis of head-and-neck cancers. It is assumed that direct stimulation... Although there have been many reports on the toxicity of tobacco smoke, fewer studies have reported the relationship between the smoke and carcinogenesis of head-and-neck cancers. It is assumed that direct stimulations due to tobacco smoke, such as chemical and mechanical stimulations, strongly influence the epithelium of the nasal cavity, paranasal sinuses, pharynx, and larynx. We investigated the influence of active and passive cigarette smoking on head-and-neck cancers. The subjects were 283 head-and-neck cancer patients examined at the otolaryngology department of Showa University Northern Yokohama Hospital in a 9-year and 2-month period from April 2001 to June 2010, in whom the presence or absence of active and passive cigarette smoking could be confirmed in detail. The active and passive smoking rates and the Brinkman index were retrospectively investigated according to the primary cancer site, gender, and histopathological classification. The active and passive smoking rates were high (about 90%) in patients with hypopharyngeal, laryngeal, and cervical esophageal cancers, and the Brinkman index was high in all. Squamous cell carcinoma (SCC) patients accounted for a high ratio of the head-and-neck cancer patients, and the active and passive smoking rates were significantly higher in SCC than in non-squamous cell carcinoma (non-SCC) patients (p < 0.0003). The active and passive smoking rates and the Brinkman index were high in patients with head-and-neck cancers in regions receiving strong direct stimulation from tobacco smoke, and the Brinkman index was also high in these patients, suggesting that carcinogenesis of head-and-neck cancers is strongly influenced by direct tobacco smoke stimulation. 展开更多
关键词 Head-and-Neck CANCERS SQUAMOUS Cell Carcinoma ACTIVE SMOKING RATE PASSIVE SMOKING RATE Brinkman Index
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A Study of 100 Cases of Cervical Schwannoma Treated with Inter-Capsular Resection
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作者 Toshikazu Shimane Shunya Egawa +7 位作者 yukiomi kushihashi Hitoshi Sato Yoshiro Saito Yuya Kurasawa Takashi Moriya Hirano Koujiro Hideyuki Katsuta Kenichiro Ikeda 《International Journal of Otolaryngology and Head & Neck Surgery》 2020年第2期61-67,共7页
Background: Cervical schwannoma is a relatively rare disease, and it is difficult to experience many surgical cases because it may be followed up without surgery. We examined 100 patients who underwent inter-capsular ... Background: Cervical schwannoma is a relatively rare disease, and it is difficult to experience many surgical cases because it may be followed up without surgery. We examined 100 patients who underwent inter-capsular resection for cervical schwannomas at our center and classified the patients according to the nerve of origin. Methods: We retrospectively reviewed 100 patients who underwent inter-capsular resection for cervical schwannoma at our center from April 2005 to September 2019. We examined the patient’s characteristics including age, sex, tumor size (maximum diameter), origin nerve, preoperative symptoms, and postoperative neurological deficits for all cases. We classified the cases according to the nerve of origin and the occurrence of postoperative neurological deficits. Results: The occurrence of postoperative neurological deficit for all cases was as follows: “none” was 73%, “temporary paralysis” was 21%, and “permanent paralysis” was 6%. In the case of vagus nerve: “none” was 65.4%, “temporary paralysis” was 23.1%, “permanent paralysis” was 11.5%. In the case of sympathetic nerve: “none” was 64.7%, “temporary paralysis” was 29.4%, “permanent paralysis” was 5.9%. In the case of brachial plexus: “none” was 87.0%, “temporary paralysis” was 13.0%, “permanent paralysis” was 0%. In the case of cervical and accessory nerves: “none” was 86.4%, “temporary paralysis” was 13.6%, “permanent paralysis” was 0%. In the case of facial nerve: “none” was 0%, “temporary paralysis” was 80.0%, “permanent paralysis” was 20%. In the case of lingual nerve: “none” was 80.0%, “temporary paralysis” was 20.0%, “permanent paralysis” was 0%. Conclusions: Inter-capsular resection is useful for the treatment of cervical schwannoma and a simple comparison is difficult, but probably with good results. This study provides information that will be useful for the treatment of cervical schwannoma. 展开更多
关键词 CERVICAL SCHWANNOMA Inter-Capsular RESECTION Origin Nerve Neurologi-cal DEFICIT Complication
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A Case of Bilateral Secondary Pneumothorax Shortly after the Completion of Concurrent Chemoradiotherapy for Tongue Cancer
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作者 Yoshiro Saito Hideyuki Katsuta +6 位作者 Takashi Moriya Yuya Kurasawa Hitoshi Sato Shunya Egawa yukiomi kushihashi Kenichiro Ikeda Toshikazu Shimane 《International Journal of Otolaryngology and Head & Neck Surgery》 2020年第3期93-100,共8页
Metastatic lung tumours rarely lead to development of pneumothorax, and no case of bilateral secondary pneumothorax due to lung metastases arising from tongue cancer has been reported. Here, we report a case of a pati... Metastatic lung tumours rarely lead to development of pneumothorax, and no case of bilateral secondary pneumothorax due to lung metastases arising from tongue cancer has been reported. Here, we report a case of a patient with tongue cancer with lung metastases complicated by bilateral secondary pneumothorax soon after the completion of concurrent chemoradiotherapy. A 39-year-old man with cervical lymph node metastases originating from pT2N0M0 tongue cancer underwent neck dissection and postoperative concurrent chemoradiotherapy. Shortly after the completion of chemoradiotherapy, he developed bilateral secondary pneumothorax. Subsequently, he underwent partial lung resection for the pulmonary fistulae for diagnostic and therapeutic purposes;nodular lesions found in both the lungs. The diagnosis of secondary pneumothorax was based on histopathological findings. Although all pulmonary fistulae disappeared after partial lung resection, he died of the primary disease despite our best efforts to control the metastatic pulmonary lesions. 展开更多
关键词 TONGUE Cancer METASTATIC Lung TUMOUR PNEUMOTHORAX Concurrent CHEMORADIOTHERAPY
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Case Report of a Clear-Cell Variant of Follicular Thyroid Carcinoma
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作者 yukiomi kushihashi Kenichiro Ikeda +7 位作者 Syunya Egawa Yoshiro Saito Yuya Kurasaa Takashi Moriya Sawa Arai Takefumi Yui Hideyuki Katsuta Toshikazu Shimane 《International Journal of Otolaryngology and Head & Neck Surgery》 2020年第2期68-77,共10页
Clear-cell variants of follicular carcinoma are rare subtypes of thyroid cancer. There is no unified view of the histopathological features of clear cell variants, but follicular carcinomas composed predominantly of c... Clear-cell variants of follicular carcinoma are rare subtypes of thyroid cancer. There is no unified view of the histopathological features of clear cell variants, but follicular carcinomas composed predominantly of clear cells are distinguished from clear cell variants. In clinical practice, it is important to determine whether clear cell variants arise primarily from the thyroid gland or are thyroid metastases of other clear cell carcinomas, such as renal cell carcinoma. We present a case in which a patient with initially suspected anaplastic thyroid carcinoma due to a rapidly progressive anterior neck mass was diagnosed with a clear cell variant of follicular carcinoma after a tissue biopsy. The patient was treated with lenvatinib, then his performance status improved, and he was discharged from the hospital. On day 188 after discharge, a contrast-enhanced computed tomography (CECT) scan of the neck showed further shrinkage of the tumor. However, a CECT scan of the chest revealed multiple lung metastases. On day 233 after discharge, the patient developed severe pneumonia resulting from tracheal rupture due to intratumoral necrosis. It was difficult to decide whether lenvatinib should have been discontinued or reduced when lung metastasis appeared. It is necessary to accumulate additional cases to make informed decisions about continuing lenvatinib therapy. 展开更多
关键词 Clear Cell Variant Follicular Carcinoma Thyroid Carcinoma Lenvatinib
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