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同型半胱氨酸与估计肾小球滤过率和慢性肾病的因果关系研究 被引量:1
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作者 白玉兰 黄胜珠 +5 位作者 陈泽凤 龙新阳 梁爽 林家莉 莫曾南 徐剑锋 《广西医科大学学报》 CAS 2020年第8期1512-1519,共8页
目的:传统的流行病学研究表明,同型半胱氨酸与估计肾小球滤过率(eGFR)和慢性肾病(CKD)之间存在相关性,但尚不清楚这种关联是否是因果关联。因此,本研究的目的是探讨同型半胱氨酸与eGFR和CKD之间的因果关联。方法:以与同型半胱氨酸显著... 目的:传统的流行病学研究表明,同型半胱氨酸与估计肾小球滤过率(eGFR)和慢性肾病(CKD)之间存在相关性,但尚不清楚这种关联是否是因果关联。因此,本研究的目的是探讨同型半胱氨酸与eGFR和CKD之间的因果关联。方法:以与同型半胱氨酸显著相关的18个单核苷酸多态性(SNPs)作为工具变量,本研究使用来自全基因组关联研究的汇总数据(eGFR和CKD,n=567,460)进行了两样本的孟德尔随机化(MR)分析和敏感性分析。结果:逆方差加权、MR Egger回归和加权中位数方法都显示同型半胱氨酸与eGFR和CKD无因果关联(均P>0.05)。Cochrane’s Q检验提示与同型半胱氨酸显著相关的11个SNPs之间可能存在异质性。MR Egger回归表明不存在水平多效性。Leave-one-out法表明,没有单一的SNP驱动MR分析结果。结论:同型半胱氨酸与eGFR和CKD之间不存在因果关联,即同型半胱氨酸并不直接导致eGFR降低或CKD的发生。因此,同型半胱氨酸水平不太可能是eGFR降低和/或CKD的预测风险指标或临床重要目标。 展开更多
关键词 同型半胱氨酸 估计肾小球滤过率 慢性肾病 孟德尔随机化
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男性睾酮与骨质疏松因果关系的两样本孟德尔随机化研究 被引量:1
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作者 黎远帆 颜赟坤 +7 位作者 罗茜倩 温政 陈泽凤 白玉兰 龙新阳 林睿 莫曾南 徐剑锋 《广西医科大学学报》 CAS 2020年第4期710-721,共12页
目的:运用两样本孟德尔随机化(MR)方法探讨男性血清睾酮水平与骨质疏松的因果关系,以发现新的治疗靶点。方法:以度他雄胺降低睾酮治疗前列腺癌的随机对照试验(n=3 225)的全基因组关联研究数据作为暴露数据集,来自骨质疏松症联盟的股骨颈... 目的:运用两样本孟德尔随机化(MR)方法探讨男性血清睾酮水平与骨质疏松的因果关系,以发现新的治疗靶点。方法:以度他雄胺降低睾酮治疗前列腺癌的随机对照试验(n=3 225)的全基因组关联研究数据作为暴露数据集,来自骨质疏松症联盟的股骨颈(FN)和腰椎(LS)骨密度(BMD)的汇总数据(n=3 2965)作为结果数据集。采用逆方差加权法(IVW),MR-Egger回归和加权中位数法评估因果效应关系,其他方法用于敏感性分析。结果:共有3组工具变量:创新组1,创新组2和保守组。保守组IVW结果显示,遗传决定的较高睾酮水平与FN BMD(Beta=-0.07;95%CI:-0.17~0.04)或LS BMD(Beta=-0.06;95%CI:-0.18~0.07)之间没有因果关系。MR-Egger回归证明遗传水平多效性未对因果估计结果造成偏倚,且Q统计量也未显示存在异质性。3个工具变量组在3种MR分析方法中都获得一致结果。结论:血清睾酮水平与骨质疏松在男性人群中未发现有因果关系,这表明改变血清睾酮水平可能不会降低男性骨质疏松的发病风险。 展开更多
关键词 睾酮 骨质疏松 骨密度 孟德尔随机化
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Intellectual Property Protection and New Development Pattern Construction of Xinjiang Jujube 被引量:2
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作者 Miaomiao XU yulan bai +3 位作者 Jinjin WANG Yuanpeng SUN Jin ZENG Zhiguo SUN 《Asian Agricultural Research》 2023年第7期1-8,共8页
"Three new developments"is the guiding ideology of Chinese-style high-quality development in the new era.Jujube(Zizyphus jujube Mill.)is a plant of Zizyphus of Rhamnaceae,which originated in China and has be... "Three new developments"is the guiding ideology of Chinese-style high-quality development in the new era.Jujube(Zizyphus jujube Mill.)is a plant of Zizyphus of Rhamnaceae,which originated in China and has been listed as one of the"five fruits"since ancient times.Xinjiang is the most important jujube producing area in China,and its yield has accounted for 50%of the national jujube yield.In the five prefectures and cities of southern Xinjiang,as well as the regimental farms of southern and eastern Xinjiang of Xinjiang Production and Construction Corps,the jujube industry is an advantageous characteristic industry in agriculture.This paper studied Xinjiang jujube industry and its agricultural intellectual property resources,analyzed six major issues to be further implemented,such as the"three new developments"thinking and the strategy of building an intellectual property power,and puts forward eight strategies such as coordinating the two markets and two resources to accelerate the construction of a new development pattern and dual circulation of jujube. 展开更多
关键词 Jujube(Zizyphus jujube Mill.) FRUIT Intellectual property New development pattern XINJIANG
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Intellectual Property Protection and High-quality Development of Grape Industrial Clusters in Xinjiang 被引量:2
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作者 Miaomiao XU Jinjin WANG +3 位作者 yulan bai Jin ZENG Yuanpeng SUN Zhiguo SUN 《Asian Agricultural Research》 2023年第5期1-7,共7页
This paper introduced the grape industry in Xinjiang and its agricultural intellectual property resources,and analyzed six major problems such as the ineffective leading role of intellectual property rights in high-qu... This paper introduced the grape industry in Xinjiang and its agricultural intellectual property resources,and analyzed six major problems such as the ineffective leading role of intellectual property rights in high-quality development.Finally,it proposed eight strategies to build a national-level regional fine-grain breeding base for grapes and develop“agricultural chips”in the context of the strategy of strengthening the country with intellectual property and innovation-driven development strategy. 展开更多
关键词 GRAPE Industrial clusters Intellectual property High-quality development XINJIANG
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Intellectual Property Rights and Authentic Protection of Chinese Wolfberry in Xinjiang
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作者 Miaomiao XU yulan bai +3 位作者 Yuanpeng SUN Jinjin WANG Jin ZENG Zhiguo SUN 《Medicinal Plant》 CAS 2023年第3期91-95,99,共6页
This paper introduced the biological characteristics and medicinal value of medlar(Lycium chinense Miller).It studied Chinese wolfberry industry and its agricultural intellectual property resources in Xinjiang.In addi... This paper introduced the biological characteristics and medicinal value of medlar(Lycium chinense Miller).It studied Chinese wolfberry industry and its agricultural intellectual property resources in Xinjiang.In addition,it analyzed main problems such as the lag in the construction of authentic medicinal materials bases and insufficient deep processing of related products.Finally,it proposed eight recommendations including cultivating biological species with more medicinal value and creating an advantageous area of characteristic authentic medicinal materials. 展开更多
关键词 Medlar(Lycium chinense Miller) Fruit of Chinese wolfberry(Lycii Fructus) Chinese medicinal materials Intellectual property AUTHENTICITY XINJIANG
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Intellectual Property Protection and High-Quality Development of Xinjiang Melons under the Big Food Concept
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作者 Miaomiao XU yulan bai +3 位作者 Jinjin WANG Yuanpeng SUN Jin ZENG Zhiguo SUN 《Asian Agricultural Research》 2023年第8期1-7,共7页
The development of diversified foods such as melons under the big food concept can reduce the pressure on staple food grain.Xinjiang has the advantages of building a new development pattern of dual circulation of dive... The development of diversified foods such as melons under the big food concept can reduce the pressure on staple food grain.Xinjiang has the advantages of building a new development pattern of dual circulation of diversified food industry and establishing a national diversified food safety and high-quality assurance center.The construction of an agricultural power needs the strategic support of an intellectual property power.This paper introduced and studied Xinjiang s melon industry and its agricultural intellectual property resources,analyzed the six main problems,including many idle land resources have not been developed into melon fields and the role of melons in diversified food supply systems not well played.Finally,it proposed to vigorously develop diversified food industries such as melons in Xinjiang and establish an eight-point strategy such as national diversified food safety and high-quality assurance center. 展开更多
关键词 Big food concept Strategy of building an intellectual property power MELON Intellectual property INHERITANCE Innovation and development Xinjiang
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蒙药结合疗术治疗慢性支气管炎的体会
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作者 白玉兰 《中国蒙医药(蒙)》 2023年第3期147-149,共3页
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蒙医坐疗法与蒙药结合治疗妇女赫依布日勒得森病
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作者 白玉兰 《中国蒙医药(蒙)》 2023年第8期55-57,共3页
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