Endogenous retroviruses(ERVs)are viral elements that have been incorporated into the host genomes of mammals over time and have evolved to become part of the host genome.Some ERVs have been domesticated and serve a ro...Endogenous retroviruses(ERVs)are viral elements that have been incorporated into the host genomes of mammals over time and have evolved to become part of the host genome.Some ERVs have been domesticated and serve a role in host development and health.HML-2,a recently integrated family of human endogenous retrovirus K(HERVK)(Garcia-Montojo et al.,2018),is an example of such ERVs and is transcribed during early human development to encode viral proteins that are proposed to promote antiviral immune response and specialization of primordial germ cells(Grow et al.,2015;Xiang et al.,2022).展开更多
文摘Endogenous retroviruses(ERVs)are viral elements that have been incorporated into the host genomes of mammals over time and have evolved to become part of the host genome.Some ERVs have been domesticated and serve a role in host development and health.HML-2,a recently integrated family of human endogenous retrovirus K(HERVK)(Garcia-Montojo et al.,2018),is an example of such ERVs and is transcribed during early human development to encode viral proteins that are proposed to promote antiviral immune response and specialization of primordial germ cells(Grow et al.,2015;Xiang et al.,2022).
