Short Retraction Notice? This article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE's?Retraction Guidelines. The aim is to promote the circulation o...Short Retraction Notice? This article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE's?Retraction Guidelines. The aim is to promote the circulation of scientific research by offering an ideal research publication platform with due consideration of internationally accepted standards on publication ethics. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have caused. Please see the?article page?for more details. The full retraction notice in PDF is preceding the original paper which is marked "RETRACTED".展开更多
Distant supervision has the ability to generate a huge amount training data.Recently,the multi-instance multi-label learning is imported to distant supervision to combat noisy data and improve the performance of relat...Distant supervision has the ability to generate a huge amount training data.Recently,the multi-instance multi-label learning is imported to distant supervision to combat noisy data and improve the performance of relation extraction.But multi-instance multi-label learning only uses hidden variables when inference relation between entities,which could not make full use of training data.Besides,traditional lexical and syntactic features are defective reflecting domain knowledge and global information of sentence,which limits the system’s performance.This paper presents a novel approach for multi-instance multilabel learning,which takes the idea of fuzzy classification.We use cluster center as train-data and in this way we can adequately utilize sentencelevel features.Meanwhile,we extend feature set by paragraph vector,which carries semantic information of sentences.We conduct an extensive empirical study to verify our contributions.The result shows our method is superior to the state-of-the-art distant supervised baseline.展开更多
An effective therapeutic regimen for hepatic fibrosis requires a deep understanding of the pathogenesis mechanism.Hepatic fibrosis is characterized by activated hepatic stellate cells(aHSCs)with an excessive productio...An effective therapeutic regimen for hepatic fibrosis requires a deep understanding of the pathogenesis mechanism.Hepatic fibrosis is characterized by activated hepatic stellate cells(aHSCs)with an excessive production of extracellular matrix.Although promoted activation of HSCs by M2 macrophages has been demonstrated,the molecular mechanism involved remains ambiguous.Herein,we propose that the vitamin D receptor(VDR)involved in macrophage polarization may regulate the communication between macrophages and HSCs by changing the functions of exosomes.We confirm that activating the VDR can inhibit the effect of M2 macrophages on HSC activation.The exosomes derived from M2 macrophages can promote HSC activation,while stimulating VDR alters the protein profiles and reverses their roles in M2 macrophage exosomes.Smooth muscle cell-associated protein 5(SMAP-5)was found to be the key effector protein in promoting HSC activation by regulating autophagy flux.Building on these results,we show that a combined treatment of a VDR agonist and a macrophage-targeted exosomal secretion inhibitor achieves an excellent anti-hepatic fibrosis effect.In this study,we aim to elucidate the association between VDR and macrophages in HSC activation.The results contribute to our understanding of the pathogenesis mechanism of hepatic fibrosis,and provide potential therapeutic targets for its treatment.展开更多
Intelligent construction technology has been widely used in the field of railway engineering.This work first analyzes the connotation,function,and characteristics of intelligent construction of railway engineering(ICR...Intelligent construction technology has been widely used in the field of railway engineering.This work first analyzes the connotation,function,and characteristics of intelligent construction of railway engineering(ICRE)and establishes its system structure from three dimensions,namely,life cycle,layers of management,and intelligent function,to deeply understand the development situation of intelligent railway construction in China.Second,seven key technical support systems of ICRE,which include building information modeling(BIM)standard system for China’s railway sector,technology management platform and life cycle management based on BIM-hGIS(geography information system),ubiquitous intelligent perception system,intelligent Intemet-of-Things(IoT)communication system based on mobile interconnection,construction management platform based on cloud computing and big data,unmanned operation system based on artificial intelligence,intelligent machinery and robot,and intelligent operation and maintenance system based on BIM and PHM(prediction and health management),are established.Third,ICRE is divided into three development stages:primary(perception),intermediate(substitution),and advanced(intelligence).The evaluation index system of each stage is provided from the aspects of technology and function.Finally,this work summarizes and analyzes the application situation of ICRE in the entire railway sector of China,represented by Beijing-Zhangjiakou and Beijing-Xiong’an high-speed railways.Result shows that the technical support systems of the ICRE have emerged in China and are still in the process of deepening basic technology research and preliminary application.In the future,the ICRE of China’s railway sector will develop toward a higher stage.展开更多
Li-rich manganese-based cathode materials(LR) are considered as excellent cathode materials for a new generation of lithium-ion batteries causes their outstanding electrochemical performance, friendly price, and envir...Li-rich manganese-based cathode materials(LR) are considered as excellent cathode materials for a new generation of lithium-ion batteries causes their outstanding electrochemical performance, friendly price, and environmental friendliness. But defects such as rapid voltage decay and loss of lattice oxygen limit their applications. The electrochemical performance of LR has to be improved by means of modification. The previous single modification methods like element doping, surface coating, structure design, etc. can only optimize the electrochemical performance of LR from one aspect. Recently, multiple modifications,which can combine the advantages of multiple modifications, have been favored by researchers. Here, we comprehensively review the recent progress of multiple modification of LR based on the combination of different modification means. The review and summary of the multiple modification of LR will play a guiding role in its development in the future.展开更多
文摘Short Retraction Notice? This article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE's?Retraction Guidelines. The aim is to promote the circulation of scientific research by offering an ideal research publication platform with due consideration of internationally accepted standards on publication ethics. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have caused. Please see the?article page?for more details. The full retraction notice in PDF is preceding the original paper which is marked "RETRACTED".
文摘Distant supervision has the ability to generate a huge amount training data.Recently,the multi-instance multi-label learning is imported to distant supervision to combat noisy data and improve the performance of relation extraction.But multi-instance multi-label learning only uses hidden variables when inference relation between entities,which could not make full use of training data.Besides,traditional lexical and syntactic features are defective reflecting domain knowledge and global information of sentence,which limits the system’s performance.This paper presents a novel approach for multi-instance multilabel learning,which takes the idea of fuzzy classification.We use cluster center as train-data and in this way we can adequately utilize sentencelevel features.Meanwhile,we extend feature set by paragraph vector,which carries semantic information of sentences.We conduct an extensive empirical study to verify our contributions.The result shows our method is superior to the state-of-the-art distant supervised baseline.
基金supported by the National Natural Science Foundation of China(Nos.81930099,81773664,82130102,92159304,81703585,and 81903651)the Natural Science Foundation of Jiangsu Province(Nos.BK20212011 and BK20180565)+4 种基金the Technology Innovation Project of Nucleic Acid Drug from National Center of Technology Innovation for Biopharmaceuticals(No.NCTIB2022HS01014)the“Double First-Class”University Project(No.CPU2022QZ05)the 111 Project from the Ministry of Education of China and the State Administration of Foreign Expert Affairs of China(Nos.111-2-07 and B17047)the Fundamental Research Funds for the Central Universities of China(No.2632022ZD11)the Open Project of State Key Laboratory of Natural Medicines(No.SKLNMZZ202017),China.
文摘An effective therapeutic regimen for hepatic fibrosis requires a deep understanding of the pathogenesis mechanism.Hepatic fibrosis is characterized by activated hepatic stellate cells(aHSCs)with an excessive production of extracellular matrix.Although promoted activation of HSCs by M2 macrophages has been demonstrated,the molecular mechanism involved remains ambiguous.Herein,we propose that the vitamin D receptor(VDR)involved in macrophage polarization may regulate the communication between macrophages and HSCs by changing the functions of exosomes.We confirm that activating the VDR can inhibit the effect of M2 macrophages on HSC activation.The exosomes derived from M2 macrophages can promote HSC activation,while stimulating VDR alters the protein profiles and reverses their roles in M2 macrophage exosomes.Smooth muscle cell-associated protein 5(SMAP-5)was found to be the key effector protein in promoting HSC activation by regulating autophagy flux.Building on these results,we show that a combined treatment of a VDR agonist and a macrophage-targeted exosomal secretion inhibitor achieves an excellent anti-hepatic fibrosis effect.In this study,we aim to elucidate the association between VDR and macrophages in HSC activation.The results contribute to our understanding of the pathogenesis mechanism of hepatic fibrosis,and provide potential therapeutic targets for its treatment.
文摘Intelligent construction technology has been widely used in the field of railway engineering.This work first analyzes the connotation,function,and characteristics of intelligent construction of railway engineering(ICRE)and establishes its system structure from three dimensions,namely,life cycle,layers of management,and intelligent function,to deeply understand the development situation of intelligent railway construction in China.Second,seven key technical support systems of ICRE,which include building information modeling(BIM)standard system for China’s railway sector,technology management platform and life cycle management based on BIM-hGIS(geography information system),ubiquitous intelligent perception system,intelligent Intemet-of-Things(IoT)communication system based on mobile interconnection,construction management platform based on cloud computing and big data,unmanned operation system based on artificial intelligence,intelligent machinery and robot,and intelligent operation and maintenance system based on BIM and PHM(prediction and health management),are established.Third,ICRE is divided into three development stages:primary(perception),intermediate(substitution),and advanced(intelligence).The evaluation index system of each stage is provided from the aspects of technology and function.Finally,this work summarizes and analyzes the application situation of ICRE in the entire railway sector of China,represented by Beijing-Zhangjiakou and Beijing-Xiong’an high-speed railways.Result shows that the technical support systems of the ICRE have emerged in China and are still in the process of deepening basic technology research and preliminary application.In the future,the ICRE of China’s railway sector will develop toward a higher stage.
基金supported by the Natural Science Foundation of Hunan Province(Nos.2021JJ30823 and 2020JJ2048)National Natural Science Foundation of China(No.51974368)。
文摘Li-rich manganese-based cathode materials(LR) are considered as excellent cathode materials for a new generation of lithium-ion batteries causes their outstanding electrochemical performance, friendly price, and environmental friendliness. But defects such as rapid voltage decay and loss of lattice oxygen limit their applications. The electrochemical performance of LR has to be improved by means of modification. The previous single modification methods like element doping, surface coating, structure design, etc. can only optimize the electrochemical performance of LR from one aspect. Recently, multiple modifications,which can combine the advantages of multiple modifications, have been favored by researchers. Here, we comprehensively review the recent progress of multiple modification of LR based on the combination of different modification means. The review and summary of the multiple modification of LR will play a guiding role in its development in the future.
