PoEC: A Cross-Blockchain Consensus Mechanism for Governing Blockchain by Blockchain

The research on the governing blockchain by blockchain supervision system is an important development trend of blockchain technology.In this system there is a supervisory blockchain managing and governing the supervised blockchain based on blockchain technology,results in a uniquely cross-blockchain demand to consensus mechanism for solving the trust problem between supervisory blockchain and supervised blockchain.To solve this problem,this paper proposes a cross-blockchain consensus mechanism based on smart contract and a set of smart contracts endorse the crossblockchain consensus.New consensus mechanism called Proof-of-EndorseContracts(PoEC)consensus,which firstly transfers the consensus reached in supervisory blockchain to supervised blockchain by supervisory nodes,then packages the supervisory block in supervisory blockchain and transmits it to the smart contract deployed in the supervised blockchain,finally miners in supervised blockchain will execute and package the new block according to the status of the smart contract.The core part of the consensus mechanism is Endorse Contracts which designed and implemented by us and verified the effectiveness through experiments.PoEC consensus mechanism and Endorse Contracts support the supervised blockchain to join the governing blockchain by blockchain system without changing the original consensus mechanism,which has the advantages of low cost,high scalability and being able to crossblockchain.This paper proves that our method can provide a feasible crossblockchain governance scheme for the field of blockchain governance.

Functional nanoemulsions: Controllable low-energy nanoemulsification and advanced biomedical application

Nanoemulsions are widely used as advanced pharmaceutical delivery systems in biomedical field, due to their high encapsulation efficiency and good therapy efficacy.Nanoemulsification techniques that produce nanoemulsions with controllable sizes and compositions are promising for creating advanced nanoemulsion systems for pharmaceutical delivery.This review summarizes recent advances on low-energy emulsification techniques for producing nanoemulsions, and the use of these nanoemulsions as advanced pharmaceutical delivery systems and as templates to create drug-loaded functional particles for biomedical application.First, nanoemulsification techniques that utilize elaborate interfacial physics/chemistry and micro-/nano-fluidics, featured with relatively-low energy input, to produce nanoemulsions with controllable sizes and compositions, are introduced.Uses of these nanoemulsions to create nanoemulsionincorporated milli-particles, drug-loaded nanoparticles and nanoparticle-incorporated microparticles with sizes ranging from several millimeters to sub-10 nm are emphasized.Flexible and efficient use of the nanoemulsions, functional nanoparticles and milli-/micro-particles integrated with nanoemulsions or nanoparticles for advanced pharmaceutical delivery in biomedical field are highlighted, with focus on how the interplay between their sizes and compositions achieve desired pharmaceutical-delivery performances.Finally, perspectives on further advances on the controllable production of nanoemulsions are provided.