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Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures
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作者 yun-jian dai Zheng-Hao Xu +5 位作者 Bo Feng Ceng-Lin Xu Hua-Wei Zhao Deng-Chang Wu Wei-Wei Hu Zhong Chen 《Neuroscience Bulletin》 SCIE CAS CSCD 2014年第6期913-922,共10页
Gender differences are involved in many neurological disorders including epilepsy. However, little is known about the effect of gender difference on the risk of epilepsy in adults with a specific early pathological st... Gender differences are involved in many neurological disorders including epilepsy. However, little is known about the effect of gender difference on the risk of epilepsy in adults with a specific early pathological state such as complex febrile seizures(FSs) in infancy. Here we used a well-established complex FS model in rats and showed that:(1) the susceptibility to seizures induced by hyperthermia, pentylenetetrazol(PTZ), and maximal electroshock(MES) was similar in male and female rat pups, while males were more susceptible to PTZ- and MES-induced seizures than age-matched females in normal adult rats;(2) adult rats with complex FSs in infancy acquired higher seizure susceptibility than normal rats; importantly, female FS rats were more susceptible to PTZ and MES than male FS rats; and(3) the protein expression of interleukin-1β, an infl ammatory factor associated with seizure susceptibility, was higher in adult FS females than in males, which may reflect a gender-difference phenomenon of seizure susceptibility. Our results provide direct evidence that the acquired seizure susceptibility after complex FSs is gender-dependent. 展开更多
关键词 gender difference complex febrile seizures seizure susceptibility EPILEPSY IL-1Β
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Correction to: Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures
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作者 yun-jian dai Zheng-Hao Xu +5 位作者 Bo Feng Ceng-Lin Xu Hua-Wei Zhao Deng-Chang Wu Wei-Wei Hu Zhong Chen 《Neuroscience Bulletin》 SCIE CAS CSCD 2018年第2期403-404,共2页
In the original publication of the article, the representativeEEG of female rat pups with FS in Figure 1 C and D wasincorrectly intercepted from that of male rat pups. Thiscorrection does not affect the conclusions of... In the original publication of the article, the representativeEEG of female rat pups with FS in Figure 1 C and D wasincorrectly intercepted from that of male rat pups. Thiscorrection does not affect the conclusions of the paper.Figure 1 has been corrected on the online PDF version anddisplayed below. 展开更多
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