Fluoxetine, an anti-depressant drug, has recently been shown to provide neuroprotection in central nervous system injury, but its roles in subarachnoid hemorrhage(SAH) remain unclear. In this study, we aimed to evalua...Fluoxetine, an anti-depressant drug, has recently been shown to provide neuroprotection in central nervous system injury, but its roles in subarachnoid hemorrhage(SAH) remain unclear. In this study, we aimed to evaluate whether fluoxetine attenuates early brain injury(EBI) after SAH. We demonstrated that intraperitoneal injection of fluoxetine(10 mg/kg per day) significantly attenuated brain edema and blood-brain barrier(BBB) disruption, microglial activation, and neuronal apoptosis in EBI after experimental SAH, as evidenced by the reduction of brain water content and Evans blue dye extravasation, prevention of disruption of the tight junction proteins zonula occludens-1, claudin-5, and occludin, a decrease of cells staining positive for Iba-1, ED-1, and TUNEL and a decline in IL-1 b, IL-6, TNF-a, MDA, 3-nitrotyrosine, and 8-OHDG levels. Moreover, fluoxetine significantly improved the neurological deficits of EBI and long-term sensorimotor behavioral deficits following SAH in a rat model. These results indicated that fluoxetine has a neuroprotective effect after experimental SAH.展开更多
The overarching goal of present study is to investigate the effects of Ir and Pd additions on the oxidation behaviour of PtAl coatings. Prior to depositing standard PtAl coating, Ir layer was electroplated by IrBr 3 a...The overarching goal of present study is to investigate the effects of Ir and Pd additions on the oxidation behaviour of PtAl coatings. Prior to depositing standard PtAl coating, Ir layer was electroplated by IrBr 3 aqueous solution while Pd layer was prepared using electroless deposition. Comparing with normal PtAl coating, cyclic oxidation tests were carried out on both the Ir-and Pd-modified aluminide coatings. The results showed that Ir-modified PtAl coating exhibited better oxidation resistance than both Pd-modified and normal PtAl coatings because Ir partly served as diffusion barrier to reserve Al while Pd did not.展开更多
基金supported by the National Natural Science Foundation of China (81601938)the Natural Science Fund of Shaanxi Province (2016JQ8010)the Science and Technology Projects Fund of Xi’an city (2016050SF/YX06(6))
文摘Fluoxetine, an anti-depressant drug, has recently been shown to provide neuroprotection in central nervous system injury, but its roles in subarachnoid hemorrhage(SAH) remain unclear. In this study, we aimed to evaluate whether fluoxetine attenuates early brain injury(EBI) after SAH. We demonstrated that intraperitoneal injection of fluoxetine(10 mg/kg per day) significantly attenuated brain edema and blood-brain barrier(BBB) disruption, microglial activation, and neuronal apoptosis in EBI after experimental SAH, as evidenced by the reduction of brain water content and Evans blue dye extravasation, prevention of disruption of the tight junction proteins zonula occludens-1, claudin-5, and occludin, a decrease of cells staining positive for Iba-1, ED-1, and TUNEL and a decline in IL-1 b, IL-6, TNF-a, MDA, 3-nitrotyrosine, and 8-OHDG levels. Moreover, fluoxetine significantly improved the neurological deficits of EBI and long-term sensorimotor behavioral deficits following SAH in a rat model. These results indicated that fluoxetine has a neuroprotective effect after experimental SAH.
基金sponsored by the‘Liaoning BaiQian Wan Talents’Programpartly supported by the R&D Program in Key Fields of Guangdong Province(No.2019B010936001)。
文摘The overarching goal of present study is to investigate the effects of Ir and Pd additions on the oxidation behaviour of PtAl coatings. Prior to depositing standard PtAl coating, Ir layer was electroplated by IrBr 3 aqueous solution while Pd layer was prepared using electroless deposition. Comparing with normal PtAl coating, cyclic oxidation tests were carried out on both the Ir-and Pd-modified aluminide coatings. The results showed that Ir-modified PtAl coating exhibited better oxidation resistance than both Pd-modified and normal PtAl coatings because Ir partly served as diffusion barrier to reserve Al while Pd did not.
