基金Project supported by the Natural Science Foundation of Zhejiang Province(No.Y18H040003)the Medicine and Health Research Foundation of Zhejiang Province(Nos.2019RC012,2019KY017,2016KYA197,2015KYA028,and 2013RCA025)the Outstanding Young Scientific Research Funds of Zhejiang Provincial People’s Hospital(No.zry2015A005),China