Enantioselective α-photoalkylation of β-ketocarbonyls without any external photosensitizer was described in this work. The photoalkylation reactions, enabled solely by a chiral primary amine catalyst, provided conve...Enantioselective α-photoalkylation of β-ketocarbonyls without any external photosensitizer was described in this work. The photoalkylation reactions, enabled solely by a chiral primary amine catalyst, provided convenient constructions of all-carbon quaternary stereocenters with good activity and high enantioselectivity. Mechanism studies revealed α direct photolytic radical chain process under visible light irradiation.展开更多
基金We thank the National Natural Science Foundation of China （Nos. 21390400, 21672217 and 21521002） for financial support. S.L is supported by the National Program of Top-notch Young Professionals and Chinese Academy of Sciences （No. QYZDJSSWSLH023）. We thank Dr. Taishan Wang and Prof. Chunru Wang for their kindly help with EPR simulation.
文摘Enantioselective α-photoalkylation of β-ketocarbonyls without any external photosensitizer was described in this work. The photoalkylation reactions, enabled solely by a chiral primary amine catalyst, provided convenient constructions of all-carbon quaternary stereocenters with good activity and high enantioselectivity. Mechanism studies revealed α direct photolytic radical chain process under visible light irradiation.
