Neoadjuvant chemotherapy with capecitabine combined with oxaliplatin for mid-low locally advanced rectal cancer with negative mesorectal fascia:Long-term outcomes of a prospective trial(PKUCH-R03 trial)

Objective:To evaluate the safety and efficacy of neoadjuvant chemotherapy(NCT)in mid-low locally advanced rectal cancer with negative mesorectal fascia(MRF).Methods:This prospective,single-arm phaseⅡtrial was designed and conducted at Peking University Cancer Hospital.The patients who provided consent received 3 months of NCT(capecitabine and oxaliplatin,CapOX)followed by total mesorectal excision(TME).The primary endpoint was the rate of pathological complete response(pCR).Results:From January 2019 through December 2021,a total of 53 patients were enrolled,7.5%of whom experienced grade 3-4 adverse events during NCT.The pCR rate was 17.0%for the entire cohort,and the overall rate of postoperative complications was 37.7%(1.9%of gradeⅢa patients).The 3-year disease-free survival rate was 91.4%,and 23.5%(12/51)of the patients suffered from major low anterior resection syndrome(LARS).Postoperative complications were independently associated with major LARS.Conclusions:For patients with mid-low rectal cancer with negative MRF,3 months of NCT were found to yield a favorable tumor response with acceptable toxicity.With fair long-term survival,the NCT regimen could be associated with low rates of perioperative complications as well as acceptable anal function.

Reduced Graphene Oxide Mediated SnO_2 Nanocrystals for Enhanced Gas-sensing Properties

SnO2-reduced graphene oxide （SnO2-rGO） composites were prepared via a hydro-thermal reaction of graphene oxide （GO） and SnCI2·2H2O in the mixed solvent of ethylene glycol and water. During the redox reaction, GO was reduced to rGO while Sn2＋ was oxidized to Sn02, uniformly depositing on the surface of rGO sheets. The composites were characterized by X-ray diffraction （XRD）, scanning electron microscopy （SEM）, thermogravimetric analysis （TGA）, infrared spectra analysis （IR） and transmission electron microscopy （TEM）, respectively, and their gas sensing properties were further investigated. Compared with pure SnO2 nanoparticles, the as-prepared SnO2-rGO gas sensor and response-recovery time to ethanol and H2S at responding and low cost SnO2-rGO gas sensor could showed much better gas sensing behavior in sensitivity ow concentrations. Overall, the highly sensitive, quick- be potentially applied in environmental monitoring area.