Objectives: To describe a novel procedure to treat hemorrhage of placenta accreta spectrum disorders (PAS) or cesarean-scar pregnancy (CSP). Methods: This was a retrospective study of women under cesarean delivery wit...Objectives: To describe a novel procedure to treat hemorrhage of placenta accreta spectrum disorders (PAS) or cesarean-scar pregnancy (CSP). Methods: This was a retrospective study of women under cesarean delivery with PAS or placenta previa. Patients’ information was acquired from hospital records. A novel procedure of surgery is developed with seven major steps, including avoiding placenta incised, elevating upward the uterine, clamping the uterine arteries with sponge forceps, removing the placenta, opening the vesicouterine space and suture techniques. Results: A total of 38 patients were reviewed. Twenty-one patients diagnosed with placenta accrete syndrome and 3 patients with CSP were underwent surgery with the novel procedure of surgery and all severe hemorrhage was controlled without hysterectomy. There were 2 women with bladder injuries needing primary repair. Fourteen patients with placenta previa underwent cesarean delivery and there was no intraoperative complication of the total 14 patients. Conclusion: The seven-step approach is more secure and effective to control severe hemorrhage without other invasive procedures in cesarean delivery with PAS. It is technically easier to maintain and improve surgical skills.展开更多
For centuries,attempts have been continuously made to artificially reconstitute counterparts of in vivo organs from their tissues or cells.Only in the recent decade has organoid technology as a whole technological fie...For centuries,attempts have been continuously made to artificially reconstitute counterparts of in vivo organs from their tissues or cells.Only in the recent decade has organoid technology as a whole technological field systematically emerged and been shown to play important roles in tissue engineering.Based on their self-organizing capacities,stem cells of versatile organs,both harvested and induced,can form 3D structures that are structurally and functionally similar to their in vivo counterparts.These organoid models provide a powerful platform for elucidating the development mechanisms,modeling diseases,and screening drug candidates.In this review,we will summarize the advances of this technology for generating various organoids of tissues from the three germ layers and discuss their drawbacks and prospects for tissue engineering.展开更多
文摘Objectives: To describe a novel procedure to treat hemorrhage of placenta accreta spectrum disorders (PAS) or cesarean-scar pregnancy (CSP). Methods: This was a retrospective study of women under cesarean delivery with PAS or placenta previa. Patients’ information was acquired from hospital records. A novel procedure of surgery is developed with seven major steps, including avoiding placenta incised, elevating upward the uterine, clamping the uterine arteries with sponge forceps, removing the placenta, opening the vesicouterine space and suture techniques. Results: A total of 38 patients were reviewed. Twenty-one patients diagnosed with placenta accrete syndrome and 3 patients with CSP were underwent surgery with the novel procedure of surgery and all severe hemorrhage was controlled without hysterectomy. There were 2 women with bladder injuries needing primary repair. Fourteen patients with placenta previa underwent cesarean delivery and there was no intraoperative complication of the total 14 patients. Conclusion: The seven-step approach is more secure and effective to control severe hemorrhage without other invasive procedures in cesarean delivery with PAS. It is technically easier to maintain and improve surgical skills.
基金This study was supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16020905 and XDB19000000)the National Key Research and Development Program of China(2017YFA0505500 and 2018ZX10302207-00*-001)+1 种基金the Basic Frontier Science Research Program of Chinese Academy of Sciences(ZDBS-LYSM015)the National Natural Science Foundation of China(81830054 and 81772723).
文摘For centuries,attempts have been continuously made to artificially reconstitute counterparts of in vivo organs from their tissues or cells.Only in the recent decade has organoid technology as a whole technological field systematically emerged and been shown to play important roles in tissue engineering.Based on their self-organizing capacities,stem cells of versatile organs,both harvested and induced,can form 3D structures that are structurally and functionally similar to their in vivo counterparts.These organoid models provide a powerful platform for elucidating the development mechanisms,modeling diseases,and screening drug candidates.In this review,we will summarize the advances of this technology for generating various organoids of tissues from the three germ layers and discuss their drawbacks and prospects for tissue engineering.
