COVID-19,a highly contagious respiratory infection caused by the SARS-Co V-2 virus,was first identified in December 2019 and has rapidly expanded to become a global pandemic[1].From then on,millions of people were inf...COVID-19,a highly contagious respiratory infection caused by the SARS-Co V-2 virus,was first identified in December 2019 and has rapidly expanded to become a global pandemic[1].From then on,millions of people were infected,while the exact number of infections is difficult to determine,as not all people who are infected with the virus get tested,and some may not show any symptoms,and the number is rising as the pandemic continues.The sickness is characterized by fever,cough.展开更多
Hydromagnetic nanoliquid establish an extraordinary category of nanoliquids that unveil both liquid and magnetic attributes.The interest in the utilization of hydromagnetic nanoliquids as a heat transporting medium st...Hydromagnetic nanoliquid establish an extraordinary category of nanoliquids that unveil both liquid and magnetic attributes.The interest in the utilization of hydromagnetic nanoliquids as a heat transporting medium stem from a likelihood of regulating its flow along with heat transportation process subjected to an externally imposed magnetic field.This analysis reports the hydromagnetic nanoliquid impact on differential type(second-grade)liquid from a convectively heated extending surface.The well-known Darcy-Forchheimer aspect capturing porosity characteristics is introduced for nonlinear analysis.Robin conditions elaborating heat-mass transportation effect are considered.In addition,Ohmic dissipation and suction/injection aspects are also a part of this research.Mathematical analysis is done by implementing the basic relations of fluid mechanics.The modeled physical problem is simplified through order analysis.The resulting systems(partial differential expressions)are rendered to the ordinary ones by utilizing the apposite variables.Convergent solutions are constructed employing homotopy algorithm.Pictorial and numeric result are addressed comprehensively to elaborate the nature of sundry parameters against physical quantities.The velocity profile is suppressed with increasing Hartmann number(magnetic parameter)whereas it is enhanced with increment in material parameter(second-grade).With the elevation in thermophoresis parameter,temperature and concentration of nanoparticles are accelerated.展开更多
Ferroptosis, a recently identified form of non-apoptotic programmed cell death, has attracted significant attention in the field of cancer therapy due to its unique mechanism of cell death. To meet the demands of ferr...Ferroptosis, a recently identified form of non-apoptotic programmed cell death, has attracted significant attention in the field of cancer therapy due to its unique mechanism of cell death. To meet the demands of ferroptosis-mediated cancer treatment, several small molecule-based drugs have been reported for the implementation of ferroptosis. However, some cancer cells are inherently resistant to these drugs, and the lack of selectivity of these drugs against cancer cells can limit their clinical application. Recent advancements in light-mediated biomedical techniques offer a promising alternative for the development of ferroptotic therapy, that is photo-controlled activation of ferroptosis. In this review, we systematically summarize the current strategies for photo-controlled ferroptosis activation and detail analysis of the underlying mechanisms of those photo-controlled ferroptotic therapies. Finally, we discuss the challenges associated with photo-activated ferroptosis and provide an outlook on the future developments in ferroptotic cancer therapy.展开更多
An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation,tumor progression and metastasis.This makes iron metabolism an attractive therapeutic target.Unfor...An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation,tumor progression and metastasis.This makes iron metabolism an attractive therapeutic target.Unfortunately,current iron-based therapeutic strategies often lack effectiveness and can elicit off-target toxicities.We report here a dual-therapeutic prodrug,DOXjade,that allows for iron chelation chemo-photothermal cancer therapy.This prodrug takes advantage of the clinically approved iron chelator deferasirox(ExJade®)and the topoisomerase 2 inhibitor,doxorubicin(DOX).Loading DOXjade onto ultrathin 2D Ti_(3)C_(2) MXene nanosheets produces a construct,Ti_(3)C_(2)-PVP@DOXjade,that allows the iron chelation and chemotherapeutic functions of DOXjade to be photo-activated at the tumor sites,while potentiating a robust photothermal effect with photothermal conversion efficiencies of up to 40%.Antitumor mechanistic investigations reveal that upon activation,Ti_(3)C_(2)-PVP@DOXjade serves to promote apoptotic cell death and downregulate the iron depletion-induced iron transferrin receptor(TfR).A tumor pH-responsive iron chelation/photothermal/chemotherapy antitumor effect was achieved both in vitro and in vivo.The results of this study highlight what may constitute a promising iron chelation-based phototherapeutic approach to cancer therapy.展开更多
文摘COVID-19,a highly contagious respiratory infection caused by the SARS-Co V-2 virus,was first identified in December 2019 and has rapidly expanded to become a global pandemic[1].From then on,millions of people were infected,while the exact number of infections is difficult to determine,as not all people who are infected with the virus get tested,and some may not show any symptoms,and the number is rising as the pandemic continues.The sickness is characterized by fever,cough.
基金Institutional Fund Projects under grant no.(IFPIP:1429-135-1443)。
文摘Hydromagnetic nanoliquid establish an extraordinary category of nanoliquids that unveil both liquid and magnetic attributes.The interest in the utilization of hydromagnetic nanoliquids as a heat transporting medium stem from a likelihood of regulating its flow along with heat transportation process subjected to an externally imposed magnetic field.This analysis reports the hydromagnetic nanoliquid impact on differential type(second-grade)liquid from a convectively heated extending surface.The well-known Darcy-Forchheimer aspect capturing porosity characteristics is introduced for nonlinear analysis.Robin conditions elaborating heat-mass transportation effect are considered.In addition,Ohmic dissipation and suction/injection aspects are also a part of this research.Mathematical analysis is done by implementing the basic relations of fluid mechanics.The modeled physical problem is simplified through order analysis.The resulting systems(partial differential expressions)are rendered to the ordinary ones by utilizing the apposite variables.Convergent solutions are constructed employing homotopy algorithm.Pictorial and numeric result are addressed comprehensively to elaborate the nature of sundry parameters against physical quantities.The velocity profile is suppressed with increasing Hartmann number(magnetic parameter)whereas it is enhanced with increment in material parameter(second-grade).With the elevation in thermophoresis parameter,temperature and concentration of nanoparticles are accelerated.
基金financial support received from the National Research Foundation of Korea(CRI project no.2018R1A3B1052702,J.S.K)L.Y.thanks the China Scholarship Fund(CSC number 201907030009).
文摘Ferroptosis, a recently identified form of non-apoptotic programmed cell death, has attracted significant attention in the field of cancer therapy due to its unique mechanism of cell death. To meet the demands of ferroptosis-mediated cancer treatment, several small molecule-based drugs have been reported for the implementation of ferroptosis. However, some cancer cells are inherently resistant to these drugs, and the lack of selectivity of these drugs against cancer cells can limit their clinical application. Recent advancements in light-mediated biomedical techniques offer a promising alternative for the development of ferroptotic therapy, that is photo-controlled activation of ferroptosis. In this review, we systematically summarize the current strategies for photo-controlled ferroptosis activation and detail analysis of the underlying mechanisms of those photo-controlled ferroptotic therapies. Finally, we discuss the challenges associated with photo-activated ferroptosis and provide an outlook on the future developments in ferroptotic cancer therapy.
基金supported by the National Natural Science Foundation of China(Grant No.11904239,Y.W.W)the Creative Research Initiative of National Research Foundation of Korea(NRF)(CRI project No.2018R1A3B1052702,J.S.K.)+1 种基金Initial support for the work in Austin came from the National Institutes of Health(CA 68682 to J.L.S.)with subsequent funding from the Robert A.Welch Foundation(F-0018 to J.L.S.)supported by Brain Pool Program through the funded by the Ministry of Science and ICT(Grant No.2020H1D3A1A02080172,M.L.).
文摘An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation,tumor progression and metastasis.This makes iron metabolism an attractive therapeutic target.Unfortunately,current iron-based therapeutic strategies often lack effectiveness and can elicit off-target toxicities.We report here a dual-therapeutic prodrug,DOXjade,that allows for iron chelation chemo-photothermal cancer therapy.This prodrug takes advantage of the clinically approved iron chelator deferasirox(ExJade®)and the topoisomerase 2 inhibitor,doxorubicin(DOX).Loading DOXjade onto ultrathin 2D Ti_(3)C_(2) MXene nanosheets produces a construct,Ti_(3)C_(2)-PVP@DOXjade,that allows the iron chelation and chemotherapeutic functions of DOXjade to be photo-activated at the tumor sites,while potentiating a robust photothermal effect with photothermal conversion efficiencies of up to 40%.Antitumor mechanistic investigations reveal that upon activation,Ti_(3)C_(2)-PVP@DOXjade serves to promote apoptotic cell death and downregulate the iron depletion-induced iron transferrin receptor(TfR).A tumor pH-responsive iron chelation/photothermal/chemotherapy antitumor effect was achieved both in vitro and in vivo.The results of this study highlight what may constitute a promising iron chelation-based phototherapeutic approach to cancer therapy.
