Dear Editor,An increasing number of single-cell RNA-seq(scRNA-seq)studies gained deep insights into the gene expression heterogeneity among individual cells by cell type/state identification(Chen et al.,2019).Alternat...Dear Editor,An increasing number of single-cell RNA-seq(scRNA-seq)studies gained deep insights into the gene expression heterogeneity among individual cells by cell type/state identification(Chen et al.,2019).Alternative splicing(AS)enables genes to generate multiple isoforms through the combination of disparate exons to increase the diversity of transcriptome(Lee and Rio,2015).展开更多
基金supported by the National Natural Science Foundation of China(31771460,31671377)the National Key Research and Development Program of China(2016YFC0902100)。
文摘Dear Editor,An increasing number of single-cell RNA-seq(scRNA-seq)studies gained deep insights into the gene expression heterogeneity among individual cells by cell type/state identification(Chen et al.,2019).Alternative splicing(AS)enables genes to generate multiple isoforms through the combination of disparate exons to increase the diversity of transcriptome(Lee and Rio,2015).