Purpose: This study attempts to investigate how a user's search behavior changes in the exploratory search process in order to understand the characteristics of the user's search behavior and build a behaviora...Purpose: This study attempts to investigate how a user's search behavior changes in the exploratory search process in order to understand the characteristics of the user's search behavior and build a behavioral model.Design/methodology/approach: Forty-two matriculated full-time senior college students with a female-to-male ratio of 1 to 1 who majored in medical science in Jilin University participated in our experiment. The task of the experiment was to search for information about 'the influence of environmental pollution on daily life' in order to write a report about this topic. The research methods include concept map, query log analysis and questionnaire survey.Findings: The results indicate that exploratory search can significantly change the knowledge structure of searchers. As searchers were moving through different stages of the exploratory search process, they experienced cognitive changes, and their search behaviors were characterized by quick browsing, careful browsing and focused searching.Research limitations: The study used only one search topic, and there is no comparision or control group. Although we took search habits, personal thinking habits, personality characteristics and professional background into account, a more detailed study to analyze the effects of these factors on exploratory search behavior is needed in our further research.Practical implications: This study can serve as a reference for other researchers engaged in the same effort to construct the supporting system of exploratory search.Originality/value: Three methods are used to investigate the behavior characteristics during exploratory search.展开更多
Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictl...Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities.展开更多
Gliomas are the most common primary malignancies in the adult central nervous system(CNS),and over the course of the last decades a wealth of data on their genomic characterization has been acquired.Nevertheless,attem...Gliomas are the most common primary malignancies in the adult central nervous system(CNS),and over the course of the last decades a wealth of data on their genomic characterization has been acquired.Nevertheless,attempts to stratify patients on the basis of this work has so far conspicuously failed to identify useful treatment targets,and no phase III clinical trials conducted to date have reached a favorable outcome.We suggest that these translational failures are due to inadequacies in classifcation schemes,which fail to capture the range of biologically distinct entities that give rise to gliomas.Treating gliomas of diferent subtypes together,rather than as a set of biologically distinct but related tumors,has resulted in a classifcation scheme rich in unexplained heterogeneities,and has restricted target identifcation eforts to cell cycle and cell growth regulators.We suggest that this failure of detailed genomic characterizations to identify useful treatment targets requires a re-assessment of our assumptions concerning glioma origins.We propose a re-interpretation of glioma subtypes in the light of knowledge of the developmental pathways of the various neural lineages that make up the adult CNS.Such a developmental subtype-specifc classifcation scheme based on dys-regulated cell fate decisions may not only improve classifcation and diagnosis but,more importantly,identify potentially druggable subtype-specifc developmental vulnerabilities.展开更多
基金supported by the National Social Science Foundation(Grant No.:11BTQ045)
文摘Purpose: This study attempts to investigate how a user's search behavior changes in the exploratory search process in order to understand the characteristics of the user's search behavior and build a behavioral model.Design/methodology/approach: Forty-two matriculated full-time senior college students with a female-to-male ratio of 1 to 1 who majored in medical science in Jilin University participated in our experiment. The task of the experiment was to search for information about 'the influence of environmental pollution on daily life' in order to write a report about this topic. The research methods include concept map, query log analysis and questionnaire survey.Findings: The results indicate that exploratory search can significantly change the knowledge structure of searchers. As searchers were moving through different stages of the exploratory search process, they experienced cognitive changes, and their search behaviors were characterized by quick browsing, careful browsing and focused searching.Research limitations: The study used only one search topic, and there is no comparision or control group. Although we took search habits, personal thinking habits, personality characteristics and professional background into account, a more detailed study to analyze the effects of these factors on exploratory search behavior is needed in our further research.Practical implications: This study can serve as a reference for other researchers engaged in the same effort to construct the supporting system of exploratory search.Originality/value: Three methods are used to investigate the behavior characteristics during exploratory search.
基金supported by the National Natural Science Foundation of China(Nos.81773015 and 82072789)the National Key Research and Development Program of China(No.2019YFE0108100)the Erik Philip-Sörensen Foundation.
文摘Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities.
基金funded by National Natural Science Foundation of China (Grants 81773015,82072789,81472348,81072080 and 31711530156)the National Key Research and Development Program of China (Grants 2012DFA30470,2016YFC0902500 and 2019YFE0108100)the Erik Philip-Sörensen Foundation.
文摘Gliomas are the most common primary malignancies in the adult central nervous system(CNS),and over the course of the last decades a wealth of data on their genomic characterization has been acquired.Nevertheless,attempts to stratify patients on the basis of this work has so far conspicuously failed to identify useful treatment targets,and no phase III clinical trials conducted to date have reached a favorable outcome.We suggest that these translational failures are due to inadequacies in classifcation schemes,which fail to capture the range of biologically distinct entities that give rise to gliomas.Treating gliomas of diferent subtypes together,rather than as a set of biologically distinct but related tumors,has resulted in a classifcation scheme rich in unexplained heterogeneities,and has restricted target identifcation eforts to cell cycle and cell growth regulators.We suggest that this failure of detailed genomic characterizations to identify useful treatment targets requires a re-assessment of our assumptions concerning glioma origins.We propose a re-interpretation of glioma subtypes in the light of knowledge of the developmental pathways of the various neural lineages that make up the adult CNS.Such a developmental subtype-specifc classifcation scheme based on dys-regulated cell fate decisions may not only improve classifcation and diagnosis but,more importantly,identify potentially druggable subtype-specifc developmental vulnerabilities.
