Epidemiological studies have found that individuals with diabetes mellitus（DM） display an increased susceptibility for adverse cardiovascular outcomes when exposed to air pollution.This study was conducted to explor...Epidemiological studies have found that individuals with diabetes mellitus（DM） display an increased susceptibility for adverse cardiovascular outcomes when exposed to air pollution.This study was conducted to explore the potential mechanism linking ambient fine particles（PM2.5） and heart injury in a Type 2 DM（T2DM） animal model. The KKay mouse, an animal model of T2DM, was exposed to concentrated ambient PM2.5 or filtered air for 8 weeks via a versatile aerosol exposure and concentrator system. Simultaneously, an inhibitor of IκB kinase-2（IKK-a）（IMD-0354）, which is a blocker of nuclear factor κB（NF-κB）nuclear translocation, was administrated by intracerebroventricular injection（ICV） to regulate the NF-êB pathway. The results showed that ambient PM2.5 induced the increase of, NF-êB, cyclooxygenase-2（COX-2） and mitogen activated protein kinase（MAPK） expression in cardiac tissue, and that IMD-0354 could alleviate the inflammatory injury. The results suggested that the NF-êB pathway plays an important role in mediating the PM2.5-induced cardiovascular injury in the T2DM model. Inhibiting NFκB may be a therapeutic option in air-pollution-exacerbated cardiovascular injury in diabetes mellitus.展开更多
A high efficiency,low threshold,high repetition rate H-βFraunhofer line light at 486.1 nm was demonstrated.A high-efficiency KTP optical parametric oscillator was achieved by double-pass pumping with a high-maturity ...A high efficiency,low threshold,high repetition rate H-βFraunhofer line light at 486.1 nm was demonstrated.A high-efficiency KTP optical parametric oscillator was achieved by double-pass pumping with a high-maturity 5 kHz 532 nm laser.Thanks to the efficient intracavity frequency doubling of the circulating signal wave by a BIBO crystal,the threshold pump power of the 486.1 nm output was 0.9 W,and the maximum output power of 1.6 W was achieved under the pump power of7.5 W.The optical–optical conversion efficiency was 21.3%,with the pulse duration of 45.2 ns,linewidth of~0.12 nm,and beam quality factor M~2 of 2.83.展开更多
基金supported by National Institutes of Health (NIH) grants RO1ES018900
文摘Epidemiological studies have found that individuals with diabetes mellitus（DM） display an increased susceptibility for adverse cardiovascular outcomes when exposed to air pollution.This study was conducted to explore the potential mechanism linking ambient fine particles（PM2.5） and heart injury in a Type 2 DM（T2DM） animal model. The KKay mouse, an animal model of T2DM, was exposed to concentrated ambient PM2.5 or filtered air for 8 weeks via a versatile aerosol exposure and concentrator system. Simultaneously, an inhibitor of IκB kinase-2（IKK-a）（IMD-0354）, which is a blocker of nuclear factor κB（NF-κB）nuclear translocation, was administrated by intracerebroventricular injection（ICV） to regulate the NF-êB pathway. The results showed that ambient PM2.5 induced the increase of, NF-êB, cyclooxygenase-2（COX-2） and mitogen activated protein kinase（MAPK） expression in cardiac tissue, and that IMD-0354 could alleviate the inflammatory injury. The results suggested that the NF-êB pathway plays an important role in mediating the PM2.5-induced cardiovascular injury in the T2DM model. Inhibiting NFκB may be a therapeutic option in air-pollution-exacerbated cardiovascular injury in diabetes mellitus.
基金supported by the National Natural Science Foundation of China(No.62175181)。
文摘A high efficiency,low threshold,high repetition rate H-βFraunhofer line light at 486.1 nm was demonstrated.A high-efficiency KTP optical parametric oscillator was achieved by double-pass pumping with a high-maturity 5 kHz 532 nm laser.Thanks to the efficient intracavity frequency doubling of the circulating signal wave by a BIBO crystal,the threshold pump power of the 486.1 nm output was 0.9 W,and the maximum output power of 1.6 W was achieved under the pump power of7.5 W.The optical–optical conversion efficiency was 21.3%,with the pulse duration of 45.2 ns,linewidth of~0.12 nm,and beam quality factor M~2 of 2.83.
