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Damage and fracture model for eutectic composite ceramics 被引量:2
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作者 Jinfeng Yu Xinhua Ni +2 位作者 Xiequan Liu yunwei fu Zhihong Du 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2019年第1期190-200,I0006,共12页
Study of damage and fracture models to analyze the fracture mechanism of eutectic composite ceramics is of considerable importance because no accurate fracture models are available for these materials. Eutectic compos... Study of damage and fracture models to analyze the fracture mechanism of eutectic composite ceramics is of considerable importance because no accurate fracture models are available for these materials. Eutectic composite ceramics are composed of microcells with random direction. We present herein a model that predicts the damage and fracture of eutectic composite ceramics based on analysis of defect stability and the damage localization band. Firstly, given the microstructure of eutectic composite ceramics, a mesodomain and a microcell model are constructed. The local stress field in the mesodomain is then analyzed based on the interaction direct derivative estimate. Secondly, the stability of a defect around particles in a microcell is analyzed, and the stress intensity factor of an annular defect under the applied stress field and the residual stress field in the particle are calculated. The stress intensity factor of a defect is controlled by the residual stress when the defect extension is small. However, it is controlled by the applied stress when the defect extension is large. Finally, a model for the damage localization band at the crack tip is constructed based on the Dugdale-Barenblatt model. The residual intensity is the important factor affecting the length of the damage localization band. When the damage variables reach their largest value, the residual in ten sity and the length of the damage localization band attain their minimum value. This work provides the theoretical basis for further study of the damage mechanics of eutectic composite ceramics and guides the engineering applications of these materials. 展开更多
关键词 MICROCELL Interaction direct DERIVATIVE ESTIMATE DEFECT stability Damage LOCALIZATION BAND
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光干预降低可卡因记忆消退后复吸行为的神经环路机制
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作者 富昀炜 杨妍 +8 位作者 黄鲁 黄晓丹 杨倩 陶倩 吴冀津 苏国辉 林嵩 袁逖飞 任超然 《Science Bulletin》 SCIE EI CAS CSCD 2023年第18期2063-2076,M0004,共15页
毒品成瘾已经成为一个严峻挑战,特别是因滥用造成的可卡因高复吸率给社会带来严重负担。尽管我们在神经生物学层面对成瘾的理解取得了显著进展,但仍缺乏有效降低复吸的戒断手段.在这项研究中,我们发现在可卡因戒断期实施亮光干预(BLT)... 毒品成瘾已经成为一个严峻挑战,特别是因滥用造成的可卡因高复吸率给社会带来严重负担。尽管我们在神经生物学层面对成瘾的理解取得了显著进展,但仍缺乏有效降低复吸的戒断手段.在这项研究中,我们发现在可卡因戒断期实施亮光干预(BLT)并结合消退训练可防止可卡因驱动的复吸行为,该效应是通过丘脑-外侧核通路所介导。实验证实,在可卡因戒断进程中,外侧核(LHb)被激活,而通过BLT抑制LHb可减少可卡因驱动的复吸行为:本文阐明了BLT的作用是通过激活投射至LHb的腹外侧膝状体和膝状体间小叶(VLGN/IGL)神经元或抑制该通路中突触后LHb神经元实现。此外,BLT可以改善药物戒断引起的负性情绪。本研究结果表明在可卡因戒断期间施加BLT可能成为一种实现药物戒除的有效手段. 展开更多
关键词 Light treatment Lateral habenula Cocaine memory Visual circuit
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