Oil spills result in tremendous damage to the environment and ecosystem.In this study,several p-alkoxybenzoyl-based gelators(1,2a,2b,2c,3)synthesized from commercially available materials were designed for recovering ...Oil spills result in tremendous damage to the environment and ecosystem.In this study,several p-alkoxybenzoyl-based gelators(1,2a,2b,2c,3)synthesized from commercially available materials were designed for recovering oil from an oil–water mixture.Gels with remarkable gelation ability in various oils were characterized by nuclear magnetic resonance,Fourier transform infrared spectroscopy and X-ray diffraction to study the driving forces of self-assembly.Notably,these gelators could achieve the goal of recycling oil from the oil–water mixture at room temperature.In addition,gelator 2b could be used to remove toxic dyes from aqueous solutions with high efficiency.Therefore,these compounds were considered promising materials for oil spill recovery and dye removal due to their practicality and high efficiency.展开更多
Fatty acids are energy substrates and cell components which participate in regulating signal transduction,transcription factor activity and secretion of bioactive lipid mediators.The acyl-CoA synthetases(ACSs)family c...Fatty acids are energy substrates and cell components which participate in regulating signal transduction,transcription factor activity and secretion of bioactive lipid mediators.The acyl-CoA synthetases(ACSs)family containing 26 family members exhibits tissue-specific distribution,distinct fatty acid substrate preferences and diverse biological functions.Increasing evidence indicates that dysregulation of fatty acid metabolism in the liver-gut axis,designated as the bidirectional relationship between the gut,microbiome and liver,is closely associated with a range of human diseases including metabolic disorders,inflammatory disease and carcinoma in the gastrointestinal tract and liver.In this review,we depict the role of ACSs in fatty acid metabolism,possible molecular mechanisms through which they exert functions,and their involvement in hepatocellular and colorectal carcinoma,with particular attention paid to long-chain fatty acids and small-chain fatty acids.Additionally,the liver-gut communication and the liver and gut intersection with the microbiome as well as diseases related to microbiota imbalance in the liver-gut axis are addressed.Moreover,the development of potentially therapeutic small molecules,proteins and compounds targeting ACSs in cancer treatment is summarized.展开更多
文摘Oil spills result in tremendous damage to the environment and ecosystem.In this study,several p-alkoxybenzoyl-based gelators(1,2a,2b,2c,3)synthesized from commercially available materials were designed for recovering oil from an oil–water mixture.Gels with remarkable gelation ability in various oils were characterized by nuclear magnetic resonance,Fourier transform infrared spectroscopy and X-ray diffraction to study the driving forces of self-assembly.Notably,these gelators could achieve the goal of recycling oil from the oil–water mixture at room temperature.In addition,gelator 2b could be used to remove toxic dyes from aqueous solutions with high efficiency.Therefore,these compounds were considered promising materials for oil spill recovery and dye removal due to their practicality and high efficiency.
基金Supported by the Interdisziplinäres Zentrum für Klinische Forschung(IZKF-MSP-06)of University Hospital Jena.
文摘Fatty acids are energy substrates and cell components which participate in regulating signal transduction,transcription factor activity and secretion of bioactive lipid mediators.The acyl-CoA synthetases(ACSs)family containing 26 family members exhibits tissue-specific distribution,distinct fatty acid substrate preferences and diverse biological functions.Increasing evidence indicates that dysregulation of fatty acid metabolism in the liver-gut axis,designated as the bidirectional relationship between the gut,microbiome and liver,is closely associated with a range of human diseases including metabolic disorders,inflammatory disease and carcinoma in the gastrointestinal tract and liver.In this review,we depict the role of ACSs in fatty acid metabolism,possible molecular mechanisms through which they exert functions,and their involvement in hepatocellular and colorectal carcinoma,with particular attention paid to long-chain fatty acids and small-chain fatty acids.Additionally,the liver-gut communication and the liver and gut intersection with the microbiome as well as diseases related to microbiota imbalance in the liver-gut axis are addressed.Moreover,the development of potentially therapeutic small molecules,proteins and compounds targeting ACSs in cancer treatment is summarized.
