Multi-photon microscopy(MPM)and coherent anti-Stokes Raman scattering(CARS)are two advanced nonlinear optical imaging techniques,which provide complementary information and have great potential in combination for noni...Multi-photon microscopy(MPM)and coherent anti-Stokes Raman scattering(CARS)are two advanced nonlinear optical imaging techniques,which provide complementary information and have great potential in combination for noninvasive in vrito biomedical applications.This paper provides a detailed discussion of the basics,development and applications of these technologies for in vrivo skin research,covering the following topics:The principle and advantage of MPM and CARS,instrumentation development for in vino applications,MPM and CARS of normal skin,application of MPM and CARS in skin cancer and disease diagnosis;application of MPM in skin disease intervention,ie.,imaging guided two-photon photothermolysis.展开更多
A theoretical and numerical model of photon and electron–positron pair production in strong-field quantum electrodynamics（QED） is described. Two processes are contained in our QED theoretical model, one is photon e...A theoretical and numerical model of photon and electron–positron pair production in strong-field quantum electrodynamics（QED） is described. Two processes are contained in our QED theoretical model, one is photon emission in the interaction of ultra-intense laser with relativistic electron（or positron）, and the other is pair production by a gamma-ray photon interacting with the laser field.This model has been included in a PIC/MCC simulation code named BUMBLEBEE 1 D, which is used to simulate the laser plasma interaction. Using this code, the evolutions of electron–positron pair and gamma-ray photon production in ultra-intense laser interaction with aluminum foil target are simulated and analyzed. The simulation results revealed that more positrons are moved in the opposite direction to the incident direction of the laser under the charge separation field.展开更多
文摘Multi-photon microscopy(MPM)and coherent anti-Stokes Raman scattering(CARS)are two advanced nonlinear optical imaging techniques,which provide complementary information and have great potential in combination for noninvasive in vrito biomedical applications.This paper provides a detailed discussion of the basics,development and applications of these technologies for in vrivo skin research,covering the following topics:The principle and advantage of MPM and CARS,instrumentation development for in vino applications,MPM and CARS of normal skin,application of MPM and CARS in skin cancer and disease diagnosis;application of MPM in skin disease intervention,ie.,imaging guided two-photon photothermolysis.
基金supported by Fundamental Research Funds for the Central Universities(Grant Nos.ZYGX2016J065 and ZYGX2016J066)
文摘A theoretical and numerical model of photon and electron–positron pair production in strong-field quantum electrodynamics（QED） is described. Two processes are contained in our QED theoretical model, one is photon emission in the interaction of ultra-intense laser with relativistic electron（or positron）, and the other is pair production by a gamma-ray photon interacting with the laser field.This model has been included in a PIC/MCC simulation code named BUMBLEBEE 1 D, which is used to simulate the laser plasma interaction. Using this code, the evolutions of electron–positron pair and gamma-ray photon production in ultra-intense laser interaction with aluminum foil target are simulated and analyzed. The simulation results revealed that more positrons are moved in the opposite direction to the incident direction of the laser under the charge separation field.
