MicroRNA Let-7g and Atherosclerosis Plaque Stabilization

Vascular atherosclerotic vulnerable plaque rupture is the primary cause of acute myocardial infarctions and strokes. Thus, stabilization of vulnerable plaques is of important clinical endeavor to decrease the fatal risk of atherosclerosis. Inflammatory infiltration, apoptosis of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs), destruction of extracellular matrix (ECM) or collagen, and neovascularization all contribute to the formation and stability of plaque. Let-7g, one miRNA of let-7 family, is related to retardation of the progress of vulnerable atherosclerosis plaque. First of all, let-7g induced preservation on vascular diseases through regulating on the intracellular Ca2+- activated protein kinase C-oxLDL-LOX-1 pathway, which resulted in reduced leukocyte adhesion to and migration across endothelium. Over expression of let-7g negatively regulated apoptosis in the ECs by targeting lectin-like oxidized LDL receptor-1(LOX-1)/CASP3 expression, therefore made the fibrous cap of plaque integrated and thick, increased the density of vascular atherosclerotic plaque. In addition, let-7g might stabilize the atherosclerotic plaque through other aspects. In this review, we focus on current and potential importance of let-7g on the stabilization of atherosclerosis plaque which might lead to the future development of an alternative strategy of CAD.

Study on catalytic mechanisms of Fe_(3)O_(4)-rGO_(x) in three typical advanced oxidation processes for tetracycline hydrochloride degradation

This study explored the catalytic mechanism and performance impacted by the materials ratio of Fe_(3)O_(4)-GO_(x) composites in three typical advanced oxidation processes(AOPs)of O_(3),peroxodisulfate(PDS)and photo-Fenton processes for tetracycline hydrochloride(TCH)degradation.The ratio of GO in the Fe_(3)O_(4)-GO_(x) composites exhibited different trends of degradation capacity in each AOPs based on different mechanisms.Fe_(3)O_(4)-rGO_(20wt%) exhibited the optimum catalytic performance which enhanced the ozone decomposition efficiency from 33.48%(ozone alone)to 51.83%with the major reactive oxygen species(ROS)of O_(2)·-.In PDS and photo-Fenton processes,Fe_(3)O_(4)-rGO_(5wt%) had the highest catalytic performance in PDS and H_(2)O_(2) decomposition for SO_(4)·–,and·OH generation,respectively.Compared with using PDS alone,PDS decomposition rate and TCH degradation rate could be increased by 5.97 and 1.73 times under Fe_(3)O_(4)-rGO_(5wt%) catalysis.In the photo-Fenton system,Fe_(3)O_(4)-rGO_(5wt%) with the best catalyst performance in H_(2)O_(2) decomposition,and TCH degradation rate increased by 2.02 times compared with blank group.Meantime,the catalytic mechanisms in those systems of that the ROS produced by conversion between Fe^(2+)/Fe^(3+)were also analyzed.

Recent advances in the application of metal organic frameworks using in advanced oxidation progresses for pollutants degradation

Metal-organic frameworks(MOFs)materials with highly ordered and porous crystalline structure,have excellent performance in advanced oxidation progresses(AOPs)for organic contaminants degradation in water treatment.This review intends to summarize the timely references and insights for the recent advances in MOFs that are used in AOPs.Starting with the preparation methodologies,including conventional hydrothermal method,electrochemical method,sol-gel method,and emerging microwave and ultrasound assisted synthesis methods.Application and mechanism for MOFs using in various AOPs of Fenton-like,photocatalysis,catalytic ozonation,persulfate catalysis and other emerging oxidation methods are emphatically discussed.We hope this review can comprehensively summarize the research and application progress of MOFs in AOPs,deepen the understanding of the catalytic mechanisms.