To the Editor:Copper is a crucial trace element in the body that plays a key role in metabolism and biological functions.Copper ions are found in two forms,Cu^(1+)and Cu^(2+),of which Cu^(1+)is the main form stored in...To the Editor:Copper is a crucial trace element in the body that plays a key role in metabolism and biological functions.Copper ions are found in two forms,Cu^(1+)and Cu^(2+),of which Cu^(1+)is the main form stored in cells.Numerous studies have shown that intracellular copper accumulation can cause oxidative stress and disrupt cellular function.[1]Different from apoptosis,autophagy,pyroptosis,and ferroptosis,cuproptosis is a newly discovered type of cell death in 2022.[2]It is mediated by protein lipoylation with ferredoxin 1(FDX1)in mitochondria.The most common pathological type of kidney cancer in adults is clear cell renal cell carcinoma(ccRCC),which accounts for 70-80%of all cases of renal cell carcinoma(RCC).[3]Currently,surgical resection is the preferred treatment for RCC,as radiotherapy,chemotherapy,and immunotherapy have shown limited effectiveness in treating ccRCC.However,cuproptosis induction may offer a new approach for ccRCC treatment.展开更多
文摘To the Editor:Copper is a crucial trace element in the body that plays a key role in metabolism and biological functions.Copper ions are found in two forms,Cu^(1+)and Cu^(2+),of which Cu^(1+)is the main form stored in cells.Numerous studies have shown that intracellular copper accumulation can cause oxidative stress and disrupt cellular function.[1]Different from apoptosis,autophagy,pyroptosis,and ferroptosis,cuproptosis is a newly discovered type of cell death in 2022.[2]It is mediated by protein lipoylation with ferredoxin 1(FDX1)in mitochondria.The most common pathological type of kidney cancer in adults is clear cell renal cell carcinoma(ccRCC),which accounts for 70-80%of all cases of renal cell carcinoma(RCC).[3]Currently,surgical resection is the preferred treatment for RCC,as radiotherapy,chemotherapy,and immunotherapy have shown limited effectiveness in treating ccRCC.However,cuproptosis induction may offer a new approach for ccRCC treatment.
