Skull defects are common in the clinical practice of neurosurgery,and they are easily complicated by encephalitis,which seriously threatens the life and health safety of patients.The treatment of encephalitis is not o...Skull defects are common in the clinical practice of neurosurgery,and they are easily complicated by encephalitis,which seriously threatens the life and health safety of patients.The treatment of encephalitis is not only to save the patient but also to benefit the society.Based on the advantages of injectable hydrogels such as minimally invasive surgery,self-adaptation to irregularly shaped defects,and easy loading and delivery of nanomedicines,an injectable hydrogel that can be crosslinked in situ at the ambient temperature of the brain for the treatment of encephalitis caused by cranial defects is developed.The hydrogel is uniformly loaded with nanodrugs formed by cationic liposomes and small molecule drugs dexmedetomidine hydrochloride(DEX-HCl),which can directly act on the meninges to achieve sustained release delivery of anti-inflammatory nanodrug preparations and achieve the goal of long-term anti-inflammation at cranial defects.This is the first time that DEX-HCl has been applied within this therapeutic system,which is innovative.Furthermore,this study is expected to alleviate the long-term suffering of patients,improve the clinical medication strategies for anti-inflammatory treatment,promote the development of new materials for cranial defect repair,and expedite the translation of research outcomes into clinical practice.展开更多
Everyday unnatural events such as trauma,accidents,military conflict,disasters,and even medical malpractice create open wounds and massive blood loss,which can be life-threatening.Fractures and large bone defects are ...Everyday unnatural events such as trauma,accidents,military conflict,disasters,and even medical malpractice create open wounds and massive blood loss,which can be life-threatening.Fractures and large bone defects are among the most common types of injuries.Traditional treatment methods usually involve rapid hemostasis and wound closure,which are convenient and fast but may result in various complications such as nerve injury,deep infection,vascular injury,and deep hematomas.To address these complications,various studies have been conducted on new materials that can be degraded in the body and reduce inflammation and abscesses in the surgical area.This review presents the latest research progress in biomaterials for bone hemostasis and repair.The mechanisms of bone hemostasis and bone healing are first introduced and then principles for rational design of biomaterials are summarized.After providing representative examples of hemostatic biomaterials for bone repair,future challenges and opportunities in the field are proposed.展开更多
基金supported by the National Natural Science Foundation of China(Nos.52302343,81825007)Beijing Outstanding Young Scientist Program(No.BJJWZYJH01201910025030),Youth Beijing Scholar Program(No.010)+1 种基金Beijing Institute of Technology Teli Young Fellow Program(No.RCPT-20220029)the Beijing Institute of Technology Research Fund Program for Young Scholars(Nos.XSQD-6120220130,XSQD-202213001).
文摘Skull defects are common in the clinical practice of neurosurgery,and they are easily complicated by encephalitis,which seriously threatens the life and health safety of patients.The treatment of encephalitis is not only to save the patient but also to benefit the society.Based on the advantages of injectable hydrogels such as minimally invasive surgery,self-adaptation to irregularly shaped defects,and easy loading and delivery of nanomedicines,an injectable hydrogel that can be crosslinked in situ at the ambient temperature of the brain for the treatment of encephalitis caused by cranial defects is developed.The hydrogel is uniformly loaded with nanodrugs formed by cationic liposomes and small molecule drugs dexmedetomidine hydrochloride(DEX-HCl),which can directly act on the meninges to achieve sustained release delivery of anti-inflammatory nanodrug preparations and achieve the goal of long-term anti-inflammation at cranial defects.This is the first time that DEX-HCl has been applied within this therapeutic system,which is innovative.Furthermore,this study is expected to alleviate the long-term suffering of patients,improve the clinical medication strategies for anti-inflammatory treatment,promote the development of new materials for cranial defect repair,and expedite the translation of research outcomes into clinical practice.
基金support from the Beijing Institute of Technology Research Fund Program for Young Scholars(XSQD-202213001 and XSQD-6120220130)the Beijing Institute of Technology Teli Young Fellow Program(RCPT-20220029).
文摘Everyday unnatural events such as trauma,accidents,military conflict,disasters,and even medical malpractice create open wounds and massive blood loss,which can be life-threatening.Fractures and large bone defects are among the most common types of injuries.Traditional treatment methods usually involve rapid hemostasis and wound closure,which are convenient and fast but may result in various complications such as nerve injury,deep infection,vascular injury,and deep hematomas.To address these complications,various studies have been conducted on new materials that can be degraded in the body and reduce inflammation and abscesses in the surgical area.This review presents the latest research progress in biomaterials for bone hemostasis and repair.The mechanisms of bone hemostasis and bone healing are first introduced and then principles for rational design of biomaterials are summarized.After providing representative examples of hemostatic biomaterials for bone repair,future challenges and opportunities in the field are proposed.
