Cu47Ti34Zr11Ni8 bulk metallic glass （BMG） matrix composites containing in situ formed TiC particles and 5-TiCu dendrite phase were developed by copper mold cast. The thermal stability and microstructure of the compo...Cu47Ti34Zr11Ni8 bulk metallic glass （BMG） matrix composites containing in situ formed TiC particles and 5-TiCu dendrite phase were developed by copper mold cast. The thermal stability and microstructure of the composites are investigated. Room temperature compression tests reveal that the composite samples exhibit higher fracture strength and distinct plastic strain of 0.2%-0.5%, comparing with that of the corresponding Cu47Ti34Zr11Ni8 monolithic BMG.展开更多
The activity of proteinase is reported to correlate with the development and progression of nonalcoholic fatty liver disease(NAFLD).Puromycin-sensitive aminopeptidase(PSA/NPEPPS)is an integral nontransmembrane enzyme ...The activity of proteinase is reported to correlate with the development and progression of nonalcoholic fatty liver disease(NAFLD).Puromycin-sensitive aminopeptidase(PSA/NPEPPS)is an integral nontransmembrane enzyme that functions to catalyze the cleavage of amino acids near the N-terminus of polypeptides.A previous study suggested that this enzyme acts as a regulator of neuropeptide activity;however,the metabolic function of this enzyme in the liver has not been explored.Here,we identified the novel role of PSA in hepatic lipid metabolism.Specifically,PSA expression was lower in fatty livers from NAFLD patients and mice(HFD,ob/ob,and db/db).PSA knockdown in cultured hepatocytes exacerbated diet-induced triglyceride accumulation through enhanced lipogenesis and attenuated fatty acid β-oxidation.Moreover,PSA mediated activation of the master regulator of antioxidant response,nuclear factor erythroid 2-related factor 2(NRF2),by stabilizing NRF2 protein expression,which further induced downstream antioxidant enzymes to protect the liver from oxidative stress and lipid overload.Accordingly,liver-specific PSA overexpression attenuated hepatic lipid accumulation and steatosis in ob/ob mice.Furthermore,in human liver tissue samples,decreased PSA expression correlated with the progression of NAFLD.Overall,our findings suggest that PSA is a pivotal regulator of hepatic lipid metabolism and its antioxidant function occurs by suppressing NRF2 ubiquitination.Moreover,PSA may be a potential biomarker and therapeutic target for treating NAFLD.展开更多
Gravitropism in plants is key for orienting organs such as the Darwin＇s description of the opposite growth direction of roots and shoots in his book The Power of Movement in Plants more than 100 years ago （Darwin, 1...Gravitropism in plants is key for orienting organs such as the Darwin＇s description of the opposite growth direction of roots and shoots in his book The Power of Movement in Plants more than 100 years ago （Darwin, 1880）. The gravitropic response of an oriented plant is divided into three sequential phases： gravity sensing, signal transmission, and the growth response. As the initial phase of gravitropism, gravity sensing （the conversion of the mechanical stimulus into a biochemical signal） has been intensively studied, but much is still unknown. The statoliths are vital for sense of balance and response to gravity, e.g. in statocytes for invertebrates and in inner ears for vertebrates.展开更多
Acquisition and analysis of customer requirements are the essential steps in high-end equipment design.Considering that Internet and big data technologies are integrated into the manufacturing industry, we propose a m...Acquisition and analysis of customer requirements are the essential steps in high-end equipment design.Considering that Internet and big data technologies are integrated into the manufacturing industry, we propose a method of analyzing customer requirements based on open-source data. First, online data are collected with focused crawlers and preprocessed to filter noise and duplicate. Then, user opinions are extracted based on the defined template, and users' sentiments are analyzed.Based on the relationship between user sentiments and attribute parameters, the parameter range that satisfies customers can be obtained. The proposed method is evaluated by using an example of new energy vehicle to verify its availability and feasibility.展开更多
基金The authors acknowledge the financial support provided by the Knowledge Innovation Program of Chinese Academy of Sciences,No.KJCX2-SW-L05the National Natural Science Foundation of China,No.50101012.
文摘Cu47Ti34Zr11Ni8 bulk metallic glass （BMG） matrix composites containing in situ formed TiC particles and 5-TiCu dendrite phase were developed by copper mold cast. The thermal stability and microstructure of the composites are investigated. Room temperature compression tests reveal that the composite samples exhibit higher fracture strength and distinct plastic strain of 0.2%-0.5%, comparing with that of the corresponding Cu47Ti34Zr11Ni8 monolithic BMG.
基金supported by the National Natural Science Foundation of China(82070881,82070836,and 81970752)the National Science Fund for Distinguished Young Scholars(81925007)the‘Talent Project’of Army Medical University(2017R013,2019R047,and 2019XQYYYJ003-2).
文摘The activity of proteinase is reported to correlate with the development and progression of nonalcoholic fatty liver disease(NAFLD).Puromycin-sensitive aminopeptidase(PSA/NPEPPS)is an integral nontransmembrane enzyme that functions to catalyze the cleavage of amino acids near the N-terminus of polypeptides.A previous study suggested that this enzyme acts as a regulator of neuropeptide activity;however,the metabolic function of this enzyme in the liver has not been explored.Here,we identified the novel role of PSA in hepatic lipid metabolism.Specifically,PSA expression was lower in fatty livers from NAFLD patients and mice(HFD,ob/ob,and db/db).PSA knockdown in cultured hepatocytes exacerbated diet-induced triglyceride accumulation through enhanced lipogenesis and attenuated fatty acid β-oxidation.Moreover,PSA mediated activation of the master regulator of antioxidant response,nuclear factor erythroid 2-related factor 2(NRF2),by stabilizing NRF2 protein expression,which further induced downstream antioxidant enzymes to protect the liver from oxidative stress and lipid overload.Accordingly,liver-specific PSA overexpression attenuated hepatic lipid accumulation and steatosis in ob/ob mice.Furthermore,in human liver tissue samples,decreased PSA expression correlated with the progression of NAFLD.Overall,our findings suggest that PSA is a pivotal regulator of hepatic lipid metabolism and its antioxidant function occurs by suppressing NRF2 ubiquitination.Moreover,PSA may be a potential biomarker and therapeutic target for treating NAFLD.
基金This work was supported by the National Basic Research Program of China （Grant No. 2011 CB710902 and 2011 CB710901） and National Natural Science Foundation of China （Grant No. 11104286 and 11372314）.ACKNOWLEDGMENTS We thank Fred Sack for discussion and providing DII-VENUS seeds Dan Szymanski for dis mutants. No conflict of interest declared.
文摘Gravitropism in plants is key for orienting organs such as the Darwin＇s description of the opposite growth direction of roots and shoots in his book The Power of Movement in Plants more than 100 years ago （Darwin, 1880）. The gravitropic response of an oriented plant is divided into three sequential phases： gravity sensing, signal transmission, and the growth response. As the initial phase of gravitropism, gravity sensing （the conversion of the mechanical stimulus into a biochemical signal） has been intensively studied, but much is still unknown. The statoliths are vital for sense of balance and response to gravity, e.g. in statocytes for invertebrates and in inner ears for vertebrates.
基金funded by National Natural Science Foundation of China(NSFC):Grant No.71690233
文摘Acquisition and analysis of customer requirements are the essential steps in high-end equipment design.Considering that Internet and big data technologies are integrated into the manufacturing industry, we propose a method of analyzing customer requirements based on open-source data. First, online data are collected with focused crawlers and preprocessed to filter noise and duplicate. Then, user opinions are extracted based on the defined template, and users' sentiments are analyzed.Based on the relationship between user sentiments and attribute parameters, the parameter range that satisfies customers can be obtained. The proposed method is evaluated by using an example of new energy vehicle to verify its availability and feasibility.
