Intense abdominal pain is a prominent feature of chronic pancreatitis and its treatment remains a major clinical challenge.Basic studies of pancreatic nerves and experimental human pain research have provided evidence...Intense abdominal pain is a prominent feature of chronic pancreatitis and its treatment remains a major clinical challenge.Basic studies of pancreatic nerves and experimental human pain research have provided evidence that pain processing is abnormal in these patients and in many cases resembles that seen in neuropathic and chronic pain disorders.An important ultimate outcome of such aberrant pain processing is that once the disease has advanced and the pathophysiological processes are firmly established,the generation of pain can become self-perpetuating and independent of the initial peripheral nociceptive drive.Consequently,the management of pain by traditional methods based on nociceptive deafferentation(e.g.,surgery and visceral nerve blockade)becomes difficult and often ineffective.This novel and improved understanding of pain aetiology requires a paradigm shift in pain management of chronic pancreatitis.Modern mechanism based pain treatments taking into account altered pain processing are likely to increasingly replace invasive therapies targeting the nociceptive source,which should be reserved for special and carefully selected cases.In this review,we offer an overview of the current available pharmacological options for pain management in chronic pancreatitis.In addition,future options for pain management are discussed with special emphasis on personalized pain medicine and multidisciplinarity.展开更多
A new electromagnetic stirring technique that is driven by hydrodynamic forces was presented. This technique offers the following advantages. First,the stirrer can be immersed in the liquid metal,thereby significantly...A new electromagnetic stirring technique that is driven by hydrodynamic forces was presented. This technique offers the following advantages. First,the stirrer can be immersed in the liquid metal,thereby significantly increasing the penetration depth of the electromagnetic forces and significantly improving the stirring efficiency; thus,this technique is particularly suitable for large-scale liquid metal. Second,under certain conditions,this technique can overcome difficulties that are encountered with traditional stirrers,such as accessing regions that are difficult to reach in working spaces with complex or narrow shapes. This stirrer also has a simpler structure than a traditional stirrer; thus,the design can be easily modified,and no external power supply is required. An experimental prototype was also presented for controlling the fluid flow rate,thereby controlling the electromagnetic force and velocity field of the driven liquid metal. The velocity distribution in a liquid Ga In Sn alloy under fluid-driven electromagnetic stirring was quantitatively measured using ultrasonic Doppler velocimetry（ UDV）. The primary results show that a remarkable velocity field has been achieved and that fluid-driven electromagnetic stirring is an effective means of stirring liquid metal. Finally,the potential applications of this technique in industry,along with key challenges,were discussed.展开更多
基金Supported by Karen Elise Jensen`s Foundation and Danish Council for Strategic research,The Danish Agency for Science,Technology and Innovation
文摘Intense abdominal pain is a prominent feature of chronic pancreatitis and its treatment remains a major clinical challenge.Basic studies of pancreatic nerves and experimental human pain research have provided evidence that pain processing is abnormal in these patients and in many cases resembles that seen in neuropathic and chronic pain disorders.An important ultimate outcome of such aberrant pain processing is that once the disease has advanced and the pathophysiological processes are firmly established,the generation of pain can become self-perpetuating and independent of the initial peripheral nociceptive drive.Consequently,the management of pain by traditional methods based on nociceptive deafferentation(e.g.,surgery and visceral nerve blockade)becomes difficult and often ineffective.This novel and improved understanding of pain aetiology requires a paradigm shift in pain management of chronic pancreatitis.Modern mechanism based pain treatments taking into account altered pain processing are likely to increasingly replace invasive therapies targeting the nociceptive source,which should be reserved for special and carefully selected cases.In this review,we offer an overview of the current available pharmacological options for pain management in chronic pancreatitis.In addition,future options for pain management are discussed with special emphasis on personalized pain medicine and multidisciplinarity.
基金Item Sponsored by the Program of "One Hundred Talented People"of the Chinese Academy of Sciences(111800M105)Chinese Academy Sciences Funding(04078400)
文摘A new electromagnetic stirring technique that is driven by hydrodynamic forces was presented. This technique offers the following advantages. First,the stirrer can be immersed in the liquid metal,thereby significantly increasing the penetration depth of the electromagnetic forces and significantly improving the stirring efficiency; thus,this technique is particularly suitable for large-scale liquid metal. Second,under certain conditions,this technique can overcome difficulties that are encountered with traditional stirrers,such as accessing regions that are difficult to reach in working spaces with complex or narrow shapes. This stirrer also has a simpler structure than a traditional stirrer; thus,the design can be easily modified,and no external power supply is required. An experimental prototype was also presented for controlling the fluid flow rate,thereby controlling the electromagnetic force and velocity field of the driven liquid metal. The velocity distribution in a liquid Ga In Sn alloy under fluid-driven electromagnetic stirring was quantitatively measured using ultrasonic Doppler velocimetry（ UDV）. The primary results show that a remarkable velocity field has been achieved and that fluid-driven electromagnetic stirring is an effective means of stirring liquid metal. Finally,the potential applications of this technique in industry,along with key challenges,were discussed.
