The planting areas of mung bean are mostly arid and semi-arid areas, and lack of irrigation conditions. Many studies have reported that fertilization can increase drought resistance. In our previous research, optimize...The planting areas of mung bean are mostly arid and semi-arid areas, and lack of irrigation conditions. Many studies have reported that fertilization can increase drought resistance. In our previous research, optimized nitrogen (N), phosphorus (P) and potassium (K) combined fertilization model was established in mung bean. In the present study, the optimal fertilization was conducted in pot trails, and mung bean varieties Bailv9 and Bailv11 were used as materials, while the four water regimes, and three fertilization ratios of F120 (optimal fertilization), F100 (conventional fertilization), F50 (half of conventional fertilization) treatments were set, to compare each fertilization ratio effects and non-fertilization condition under each water regimes respectively. Under different water conditions, the investigation of N, P, and K effects of optimal fertilization showed that the yield of Bailv9 was not sensitive to water stress and had strong drought resistance;their water sensitivity index and drought resistance coefficient were BaiLv9 as Di = 0.89 and DC = 0.79. The yield of Bailv11 was sensitive to water stress, and their drought resistance was weak;their water sensitivity index and drought resistance coefficient were BL11 Di = 1.76 DC = 0.59, and under different water treatment conditions, Bailv9 and Bailv11 all had the best yield and other related traits increase in the F120 fertilization mode compared with other fertilization and non-fertilization conditions, and the average yield increases were 31.56% and 28.08%, respectively. The pot trails conduct the drought stress treatments in mung bean varieties Bailv9, Bailv11, Bailv935 and Bailv985 to determine the function of NPK optimized fertilization for improving plants growth in drought stress condition. Compared with the mung bean varieties treated with F50, F100, and F120, the yield of Bailv9 increased by 56.20%, 81.27%, and 107.22%, respectively;compared with that of F0, the yield of Bailv11 increased by 10.18%, 19.42%, and 45.88%, respectively;Bailv935 increased by 26.52%, 61.90%, 74.16% respectively, and Bailv985 increased by 23.78%, 56.92%, 87.62% respectively. The significant performances of optimized fertilization were also verified in 20 mung bean varieties in our filed trails. The research establishes a theoretical basis for introducing the model into production practice in the next step.展开更多
To understand the current situation of institutional registration in Shaanxi Province after the implementation ofregistration system management in drug clinical trial institutions.Relevant information was collected on...To understand the current situation of institutional registration in Shaanxi Province after the implementation ofregistration system management in drug clinical trial institutions.Relevant information was collected on the“Announcement on the Accreditation of Drug Clinical Trial Institutions”issued by the National Medical Products Administration from 2005 to August 2022,the record management information system of drug and medical device clinical trial institutions,and the drug clinical trial registration and information publicity platform.A retrospective analysis was carried out in terms of institutional development,regional distribution,registered majors,principal investigators,and the number of drug clinical trials.After the implementation of institution registration,the number of drug clinical trial institutions in Shaanxi Province increased by 47.4%,884 principal investigators were registered,the number of registered majors expanded from 58 qualified to 117,and the professional scope increased by 50.4%.The policy of institution registration is conducive to promoting the rational use of medical resources and the development of drug clinical trial institutions and improving the healthy development of the pharmaceutical industry in Shaanxi Province.展开更多
Objective:To establish the quality standards for the preparation of Xiao’er Qingre enema in hospitals.Method:Thin-layer chromatography(TLC)was used to identify Radix Isatidis and Glycyrrhizae in the prescription.The ...Objective:To establish the quality standards for the preparation of Xiao’er Qingre enema in hospitals.Method:Thin-layer chromatography(TLC)was used to identify Radix Isatidis and Glycyrrhizae in the prescription.The content of(R,S)-Goitrin was determined by high-performance liquid chromatography(HPLC).Results:In TLC identification,there was no interference between the negative controls of Radix Isatidis and glycyrrhizae,and the spots were well-separated.The HPLC results of(R,S)-Goitrin showed a good linear relationship between the peak area and concentration within the range of 0.476-95.2μg·mL-1(r=0.9999).Conclusion:The TLC and HPLC methods established in this experiment are simple,reproducible,and specific,making them suitable for the quality control Xiao’er Qingre enema preparation in hospitals.展开更多
Aqueous supercapacitors(SCs)have received considerable attention owing to the utilization of low-cost,non-flammable,and low-toxicity aqueous electrolytes thus could eliminate the safety and cost concerns,but their wid...Aqueous supercapacitors(SCs)have received considerable attention owing to the utilization of low-cost,non-flammable,and low-toxicity aqueous electrolytes thus could eliminate the safety and cost concerns,but their wide temperature range applications have generally suffered from frozen of electrolyte and insufficient ionic conductivity at low temperatures.Herein,we demonstrate the feasibility of using an unconventional Deep Eutectic Solvent(DES)based on H2O-Mg(ClO4)2·6 H2O binary system as electrolyte to construct all-climate aqueous carbon-based SC.This unconventional class DES completely base on inorganic substances and achieving simply mix inexpensive salts and water together at the right proportions.Attributed to the attractive feature of extremely low freeze temperature of-69℃,this electrolyte can enable the 1.8 V carbon-based SC to fully work at-40℃with outstanding cycling stability.This DES electrolyte comprising of a single salt and a single solvent without any additive will open up an avenue for developing simple and green electrolytes to construct all-climate SC.展开更多
With the advent of the era of big data,knowledge engineering has received extensive attention.How to extract useful knowledge from massive data is the key to big data analysis.Knowledge graph technology is an importan...With the advent of the era of big data,knowledge engineering has received extensive attention.How to extract useful knowledge from massive data is the key to big data analysis.Knowledge graph technology is an important part of artificial intelligence,which provides a method to extract structured knowledge from massive texts and images,and has broad application prospects.The knowledge base with semantic processing capability and open interconnection ability can be used to generate application value in intelligent information services such as intelligent search,intelligent question answering and personalized recommendation.Although knowledge graph has been applied to various systems,the basic theory and application technology still need further research.On the basis of comprehensively expounding the definition and architecture of knowledge graph,this paper reviews the key technologies of knowledge graph construction,including the research progress of four core technologies such as knowledge extraction technology,knowledge representation technology,knowledge fusion technology and knowledge reasoning technology,as well as some typical applications.Finally,the future development direction and challenges of the knowledge graph are prospected.展开更多
Objective:To investigate the efficacy of montelukast sodium in the treatment of lung cancer patients with pulmonary infections.Methods:A total of 330 patients diagnosed with lung cancer and pulmonary infection,who wer...Objective:To investigate the efficacy of montelukast sodium in the treatment of lung cancer patients with pulmonary infections.Methods:A total of 330 patients diagnosed with lung cancer and pulmonary infection,who were admitted to the First Affiliated Hospital of Xi’an Medical University from 2020 to 2022,were selected as research subjects.They were randomly divided into two groups:a control group receiving conventional treatment and an observation group receiving conventional treatment combined with montelukast sodium.Each group consisted of 165 cases.The time required for clinical symptom improvement,the resolution of lung infection signs,and the levels of serum inflammatory factors before and after treatment were compared between the two groups.Results:The observation group exhibited significantly faster improvement in clinical symptoms compared to the control group(P<0.001).ELISA assays were conducted to detect the expression levels of IL-1β,IL-6,IL-8,and TNF-αin the serum of both groups at 1 week and 2 weeks into the treatment.The results indicated that,as the treatment progressed,the observation group displayed significantly lower levels of the four serum inflammatory factors compared to the control group(P<0.001).Conclusion:Montelukast sodium demonstrates efficacy in the treatment of patients with lung cancer complicated by pulmonary infections.These findings suggest its potential for further verification and clinical application.展开更多
Objective:To contribute to the development of clinical research on novel coronavirus by analyzing the clinical research data of COVID-19.Methods:Searches were performed on the database of“National Health Insurance In...Objective:To contribute to the development of clinical research on novel coronavirus by analyzing the clinical research data of COVID-19.Methods:Searches were performed on the database of“National Health Insurance Information Platform Medical Research Registration Information System”using the keywords“COVID-19”and“Novel coronavirus.”The search was performed till 31 December 2022.This paper presents a statistical analysis of the status quo of the registered projects in terms of the number of registered projects,the types of projects,the levels of the institutions,the types of research,the intervention measures,the research design,the main objectives of the research,and so on.Results:A total of 823 investigator-initiated clinical studies of COVID-19 were documented,and the number of studies registered peaked on December 31,2020,and December 31,2022.Among them,there were 819 items from general medical research(99.5%),812 items from medical institutions(98.7%),and 713 items from Medical Grade III,and Class A hospitals(86.6%).Among these items,534(64.9%)were observational studies.The most common intervention method used was administering existing drugs,with 140 studies utilizing them.This data analysis also included 128 case-control studies and 247 treatment-oriented studies.Conclusion:Researchers in local medical institutions have been actively carrying out clinical research related to COVID-19.However,they should refer to registered research to avoid duplicate research.展开更多
Objective:To systematically evaluate the relationship between herpes simplex virus type II(HSV-2)infection in pregnant women and the adverse pregnancy outcomes(preterm delivery,spontaneous abortion,stillbirth,monstrum...Objective:To systematically evaluate the relationship between herpes simplex virus type II(HSV-2)infection in pregnant women and the adverse pregnancy outcomes(preterm delivery,spontaneous abortion,stillbirth,monstrum,low birth weight,intrauterine growth retardation,premature rupture of membranes),so as to provide clinical guidance for the prevention and treatment of adverse pregnancy outcomes caused by HSV-2 infection in pregnant women.Methods:2140 articles were collected from PubMed,China National Knowledge Infrastructure(CNKI),and other databases for the past 20 years.According to the inclusion criteria,the literatures about the relationship between HSV-2 infection of pregnant women and adverse pregnancy outcomes were screened.The effect model was determined by heterogeneity test results,and the meta-analysis was carried out by RevMan 5.3 software.Results:The results of meta-analysis showed that the positive rate of HSV-2 was higher in the adverse pregnancy group than in the control group(odds ratio[OR]:7.92,95%confidence interval[Cl]:3.91-16.01),and the difference was statistically significant.Conclusion:HSV-2 infection will increase the risk of adverse pregnancy outcomes.Prevention and effective control of HSV-2 infection in early pregnancy can reduce the rate of adverse pregnancy outcome,which is of great significance to the promotion of eugenics.展开更多
Comprehensive Summary,In nature,fishes have evolved functional skins with effective hydrodynamic performance and anti-fouling,facilitating predation and escaping from predators.Although a large number of fish scale-in...Comprehensive Summary,In nature,fishes have evolved functional skins with effective hydrodynamic performance and anti-fouling,facilitating predation and escaping from predators.Although a large number of fish scale-inspired structured surfaces have been explored,the incorporation of mucus on the structured surfaces has been largely ignored.Inspired by the skin of Osteichthyes fishes,a Janus hydrogel coating(JHC)is successfully prepared by a two-step UV light irradiation at room temperature.The bottom side of JHC(STH)achieves a shear adhesive strength of 103.3±17.5 kPa and can strongly adhere to a large variety of surfaces,including metals,ceramic and polymers.The top surface of JHC(SLH)replicates the structure of cycloid scales,while the nature of hydrogel mimics the mucus on fish skin.SLH possesses prominent mechanical,anti-swelling,anti-fouling and drag reduction properties.The design strategy for JHC has potential applications in numerous fields,like,pipeline transportation,bioengineering,and shipping industry.展开更多
Membrane capacitive deionization(MCDI)is a cost-effective desalination technique known for its low energy consumption.The performance of MCDI cells relies on the properties of electrode materials.Activated carbon is t...Membrane capacitive deionization(MCDI)is a cost-effective desalination technique known for its low energy consumption.The performance of MCDI cells relies on the properties of electrode materials.Activated carbon is the most widely used electrode material.However,the capacitive carbon available on the market is often expensive.Here,we developed hierarchically porous biochar by combining carbonization and activation processes,using easily acquired aerobic granular sludge(AGS)from biological sewage treatment plants as a precursor.The biochar had a specific surface area of 1822.07 m^(2)g^(-1),with a micropore area ratio of 58.65%and a micropore volume of 0.576 cm3 g^(-1).The MCDI cell employing the biochar as electrodes demonstrated a specific adsorption capacity of 34.35 mg g^(-1),comparable to commercially available activated carbon electrodes.Our study presents a green and sustainable approach for preparing highly efficient,hierarchically porous biochar from AGS,offering great potential for enhanced performance in MCDI applications.展开更多
Previous studies have suggested that thrombospondin-1(TSP-1) regulates the transforming growth factor beta 1(TGF-b1)/phosphorylated Smad2/3(p Smad2/3) pathway. Moreover, TSP-1 is closely associated with epilepsy. Howe...Previous studies have suggested that thrombospondin-1(TSP-1) regulates the transforming growth factor beta 1(TGF-b1)/phosphorylated Smad2/3(p Smad2/3) pathway. Moreover, TSP-1 is closely associated with epilepsy. However, the role of the TSP-1-regulated TGFb1/p Smad2/3 pathway in seizures remains unclear. In this study, changes in this pathway were assessed following kainic acid(KA)-induced status epilepticus(SE) in rats.The results showed that increases in the TSP-1/TGF-b1/p Smad2/3 levels spatially and temporally matched the increases in glial fibrillary acidic protein(GFAP)/chondroitin sulfate(CS56) levels following KA administration.Inhibition of TSP-1 expression by small interfering RNA or inhibition of TGF-b1 activation with a Leu-Ser-Lys-Leu peptide significantly reduced the severity of KA-induced acute seizures. These anti-seizure effects were accompanied by decreased GFAP/CS56 expression and Smad2/3 phosphorylation. Moreover, inhibiting Smad2/3 phosphorylation with ponatinib or SIS3 also significantly reduced seizure severity, alongside reducing GFAP/CS56 immunoreactivity. These results suggest that the TSP-1-regulated TGF-b1/p Smad2/3 pathway plays a key role in KA-induced SE and astrogliosis, and that inhibiting this pathway may be a potential anti-seizure strategy.展开更多
Permeability is a major indicator of concrete durability,and depends primarily on the microstructure characteristics of concrete,including its porosity and pore size distribution.In this study,a variety of concrete sa...Permeability is a major indicator of concrete durability,and depends primarily on the microstructure characteristics of concrete,including its porosity and pore size distribution.In this study,a variety of concrete samples were prepared to investigate their microstructure characteristics via nuclear magnetic resonance(NMR),mercury intrusion porosimetry(MIP),and X-ray computed tomography(X-CT).Furthermore,the chloride diffusion coefficient of concrete was measured to explore its correlation with the microstructure of the concrete samples.Results show that the proportion of pores with diameters<1000 nm obtained by NMR exceeds that obtained by MIP,although the difference in the total porosity determined by both methods is minimal.X-CT measurements obtained a relatively small porosity;however,this likely reflcts the distribution of large pores more accurately.A strong correlation is observed between the chloride diffusion coefficient and the porosity or contributive porosity of pores with sizes<1000 nm.Moreover,microstructure parameters measured via NMR reveal a lower correlation coefficient R2 versus the chloride diffusion coefficient relative to the parameters determined via MIP,as NMR can measure non-connected as well as connected pores.In addition,when analyzing pores with sizes>50 um,X-CT obtains the maximal contributive porosity,followed by MIP and NMR.展开更多
Developing highly efficient and recyclable photocatalysts through harvesting solar light as energy is crucial to oxidation for industrial implementation,especially for simple transition metal oxidic catalysts without ...Developing highly efficient and recyclable photocatalysts through harvesting solar light as energy is crucial to oxidation for industrial implementation,especially for simple transition metal oxidic catalysts without precious/heavy/rare metal dopants.Herein,we like to report the use of nitrogen-doped CoMn_(2)O_(4) oxide(N–CoMn_(2)O_(4))as a heterogeneous catalyst for efficient oxidation of various alcohols such as p/m/o-methyl-substituted aromatic alcohols,p-substituted aromatic alcohols including electron-donating and electron-withdrawing substituents,heterocycle-based alcohols and secondary aromatic alcohols to the corresponding aldehydes/ketones,under visible light(>420 nm)illumination and mild condition of oxygen as oxidant and room temperature.The relation of various Co-based oxides to their catalytic performance was studied.It is shown that the Co^(2+)species in N–CoMn_(2)O_(4),obviously increased by the doping of nitrogen,are acted as catalytic active species coupled with the synergistic effect between Co and Mn species for the enhanced visible-light selective oxidation of alcohols to aldehydes.A plausible catalytic mechanism is proposed basis of control experiments and published studies,which suggests that this oxidation process probably occurs on Co^(2+)þsites via an ionic reactive oxygen species pathway and ^(1)O2 and O2⋅^(-)species are the reactive oxygen species.This simple transition metal oxide-catalyzed aerobic oxidation provides a green alternative for the manufacture of aldehydes/ketones from alcohols.展开更多
China has achieved commendable success in stabilizing human immunodeficiency virus(HIV)prevalence at a relatively low level of transmission(1).Nevertheless,the total number of people living with HIV in China rose to a...China has achieved commendable success in stabilizing human immunodeficiency virus(HIV)prevalence at a relatively low level of transmission(1).Nevertheless,the total number of people living with HIV in China rose to approximately 1.05 million,with cumulative reported acquired immune deficiency syndrome(AIDS)-related fatalities reaching 351,000 by the end of 2020(2).Since the initial infiltration of HIV into China in 1982(3),the nation has enacted over 471 national policies through 2021 to combat the epidemic.Initially,the outbreak was perceived primarily as a healthcare issue rather than the complex societal challenge that it manifested into.The Ministry of Health(MOH,now known as National Health Commission)was initially tasked with HIV prevention,issuing the nation’s first HIV/AIDS-related policy in 1984,which aimed to ban HIV-infected products and individuals from entry.Regrettably,this approach proved inadequate as significant HIV outbreaks unfolded.At this juncture,the State Council Research Office recognized the HIV epidemic as a grave societal and public health issue,posing a threat to the“Survival of the Chinese Nation”(4).Engagement at a higher governmental level became imperative to coordinate an effective response across diverse administrative agencies.展开更多
文摘The planting areas of mung bean are mostly arid and semi-arid areas, and lack of irrigation conditions. Many studies have reported that fertilization can increase drought resistance. In our previous research, optimized nitrogen (N), phosphorus (P) and potassium (K) combined fertilization model was established in mung bean. In the present study, the optimal fertilization was conducted in pot trails, and mung bean varieties Bailv9 and Bailv11 were used as materials, while the four water regimes, and three fertilization ratios of F120 (optimal fertilization), F100 (conventional fertilization), F50 (half of conventional fertilization) treatments were set, to compare each fertilization ratio effects and non-fertilization condition under each water regimes respectively. Under different water conditions, the investigation of N, P, and K effects of optimal fertilization showed that the yield of Bailv9 was not sensitive to water stress and had strong drought resistance;their water sensitivity index and drought resistance coefficient were BaiLv9 as Di = 0.89 and DC = 0.79. The yield of Bailv11 was sensitive to water stress, and their drought resistance was weak;their water sensitivity index and drought resistance coefficient were BL11 Di = 1.76 DC = 0.59, and under different water treatment conditions, Bailv9 and Bailv11 all had the best yield and other related traits increase in the F120 fertilization mode compared with other fertilization and non-fertilization conditions, and the average yield increases were 31.56% and 28.08%, respectively. The pot trails conduct the drought stress treatments in mung bean varieties Bailv9, Bailv11, Bailv935 and Bailv985 to determine the function of NPK optimized fertilization for improving plants growth in drought stress condition. Compared with the mung bean varieties treated with F50, F100, and F120, the yield of Bailv9 increased by 56.20%, 81.27%, and 107.22%, respectively;compared with that of F0, the yield of Bailv11 increased by 10.18%, 19.42%, and 45.88%, respectively;Bailv935 increased by 26.52%, 61.90%, 74.16% respectively, and Bailv985 increased by 23.78%, 56.92%, 87.62% respectively. The significant performances of optimized fertilization were also verified in 20 mung bean varieties in our filed trails. The research establishes a theoretical basis for introducing the model into production practice in the next step.
基金Project of Xi’an Science and Technology Plan(23YXYJ0163)Education and Teaching Reform Research Project of Xi’an Medical University in 2023(S202311840061)+1 种基金First Affiliated Hospital of Xi’an Medical University of China(XYYFY-2023-01)2021 Xi’an Medical University University-Level Science and Technology Innovation Team(2021TD14)。
文摘To understand the current situation of institutional registration in Shaanxi Province after the implementation ofregistration system management in drug clinical trial institutions.Relevant information was collected on the“Announcement on the Accreditation of Drug Clinical Trial Institutions”issued by the National Medical Products Administration from 2005 to August 2022,the record management information system of drug and medical device clinical trial institutions,and the drug clinical trial registration and information publicity platform.A retrospective analysis was carried out in terms of institutional development,regional distribution,registered majors,principal investigators,and the number of drug clinical trials.After the implementation of institution registration,the number of drug clinical trial institutions in Shaanxi Province increased by 47.4%,884 principal investigators were registered,the number of registered majors expanded from 58 qualified to 117,and the professional scope increased by 50.4%.The policy of institution registration is conducive to promoting the rational use of medical resources and the development of drug clinical trial institutions and improving the healthy development of the pharmaceutical industry in Shaanxi Province.
基金Xi’an Science and Technology Plan Project(Project number:23YXYJ0163)Education and Teaching Reform Research Project of Xi,an Medical University in(2023)(Project number:S202311840061)First Affiliated Hospital of Xi’an Medical University of China(Fund number:XYYFY-2023-01).
文摘Objective:To establish the quality standards for the preparation of Xiao’er Qingre enema in hospitals.Method:Thin-layer chromatography(TLC)was used to identify Radix Isatidis and Glycyrrhizae in the prescription.The content of(R,S)-Goitrin was determined by high-performance liquid chromatography(HPLC).Results:In TLC identification,there was no interference between the negative controls of Radix Isatidis and glycyrrhizae,and the spots were well-separated.The HPLC results of(R,S)-Goitrin showed a good linear relationship between the peak area and concentration within the range of 0.476-95.2μg·mL-1(r=0.9999).Conclusion:The TLC and HPLC methods established in this experiment are simple,reproducible,and specific,making them suitable for the quality control Xiao’er Qingre enema preparation in hospitals.
基金financially supported by the DNL Cooperation Fund,Chinese Academy of Sciences(DNL180307)Natural Science Foundation of Gansu Province(18JR3RA159)。
文摘Aqueous supercapacitors(SCs)have received considerable attention owing to the utilization of low-cost,non-flammable,and low-toxicity aqueous electrolytes thus could eliminate the safety and cost concerns,but their wide temperature range applications have generally suffered from frozen of electrolyte and insufficient ionic conductivity at low temperatures.Herein,we demonstrate the feasibility of using an unconventional Deep Eutectic Solvent(DES)based on H2O-Mg(ClO4)2·6 H2O binary system as electrolyte to construct all-climate aqueous carbon-based SC.This unconventional class DES completely base on inorganic substances and achieving simply mix inexpensive salts and water together at the right proportions.Attributed to the attractive feature of extremely low freeze temperature of-69℃,this electrolyte can enable the 1.8 V carbon-based SC to fully work at-40℃with outstanding cycling stability.This DES electrolyte comprising of a single salt and a single solvent without any additive will open up an avenue for developing simple and green electrolytes to construct all-climate SC.
基金This research work is implemented at the 2011 Collaborative Innovation Center for Development and Utilization of Finance and Economics Big Data Property,Universities of Hunan ProvinceHunan Provincial Key Laboratory of Big Data Science and Technology,Finance and Economics+3 种基金Key Laboratory of Information Technology and Security,Hunan Provincial Higher Education.This research is funded by the Open Foundation for the University Innovation Platform in the Hunan Province,grant number 18K103Open project,Grant Numbers 20181901CRP03,20181901CRP04,20181901CRP05Hunan Provincial Education Science 13th Five-Year Plan(Grant No.XJK016BXX001)Social Science Foundation of Hunan Province(Grant No.17YBA049).
文摘With the advent of the era of big data,knowledge engineering has received extensive attention.How to extract useful knowledge from massive data is the key to big data analysis.Knowledge graph technology is an important part of artificial intelligence,which provides a method to extract structured knowledge from massive texts and images,and has broad application prospects.The knowledge base with semantic processing capability and open interconnection ability can be used to generate application value in intelligent information services such as intelligent search,intelligent question answering and personalized recommendation.Although knowledge graph has been applied to various systems,the basic theory and application technology still need further research.On the basis of comprehensively expounding the definition and architecture of knowledge graph,this paper reviews the key technologies of knowledge graph construction,including the research progress of four core technologies such as knowledge extraction technology,knowledge representation technology,knowledge fusion technology and knowledge reasoning technology,as well as some typical applications.Finally,the future development direction and challenges of the knowledge graph are prospected.
文摘Objective:To investigate the efficacy of montelukast sodium in the treatment of lung cancer patients with pulmonary infections.Methods:A total of 330 patients diagnosed with lung cancer and pulmonary infection,who were admitted to the First Affiliated Hospital of Xi’an Medical University from 2020 to 2022,were selected as research subjects.They were randomly divided into two groups:a control group receiving conventional treatment and an observation group receiving conventional treatment combined with montelukast sodium.Each group consisted of 165 cases.The time required for clinical symptom improvement,the resolution of lung infection signs,and the levels of serum inflammatory factors before and after treatment were compared between the two groups.Results:The observation group exhibited significantly faster improvement in clinical symptoms compared to the control group(P<0.001).ELISA assays were conducted to detect the expression levels of IL-1β,IL-6,IL-8,and TNF-αin the serum of both groups at 1 week and 2 weeks into the treatment.The results indicated that,as the treatment progressed,the observation group displayed significantly lower levels of the four serum inflammatory factors compared to the control group(P<0.001).Conclusion:Montelukast sodium demonstrates efficacy in the treatment of patients with lung cancer complicated by pulmonary infections.These findings suggest its potential for further verification and clinical application.
基金This study was supported by the Project of Xi’an Science and Technology Plan(23YXYJ0163)the Education and Teaching Reform Research Project of Xi’an Medical University in 2023(S202311840061)funds from the First Affiliated Hospital of Xi’an Medical University of China(XYYFY-2023-01).
文摘Objective:To contribute to the development of clinical research on novel coronavirus by analyzing the clinical research data of COVID-19.Methods:Searches were performed on the database of“National Health Insurance Information Platform Medical Research Registration Information System”using the keywords“COVID-19”and“Novel coronavirus.”The search was performed till 31 December 2022.This paper presents a statistical analysis of the status quo of the registered projects in terms of the number of registered projects,the types of projects,the levels of the institutions,the types of research,the intervention measures,the research design,the main objectives of the research,and so on.Results:A total of 823 investigator-initiated clinical studies of COVID-19 were documented,and the number of studies registered peaked on December 31,2020,and December 31,2022.Among them,there were 819 items from general medical research(99.5%),812 items from medical institutions(98.7%),and 713 items from Medical Grade III,and Class A hospitals(86.6%).Among these items,534(64.9%)were observational studies.The most common intervention method used was administering existing drugs,with 140 studies utilizing them.This data analysis also included 128 case-control studies and 247 treatment-oriented studies.Conclusion:Researchers in local medical institutions have been actively carrying out clinical research related to COVID-19.However,they should refer to registered research to avoid duplicate research.
基金supported in part by grants from Science and Technology Innovation Team Project of Xi'an Medical University,China(2021TD14)Industrialization Project of Shaanxi Provincial Department of Education,China(20JC031)the First Affiliated Hospital of Xi'an Medical University,China(XYFYPT-2021-02).
文摘Objective:To systematically evaluate the relationship between herpes simplex virus type II(HSV-2)infection in pregnant women and the adverse pregnancy outcomes(preterm delivery,spontaneous abortion,stillbirth,monstrum,low birth weight,intrauterine growth retardation,premature rupture of membranes),so as to provide clinical guidance for the prevention and treatment of adverse pregnancy outcomes caused by HSV-2 infection in pregnant women.Methods:2140 articles were collected from PubMed,China National Knowledge Infrastructure(CNKI),and other databases for the past 20 years.According to the inclusion criteria,the literatures about the relationship between HSV-2 infection of pregnant women and adverse pregnancy outcomes were screened.The effect model was determined by heterogeneity test results,and the meta-analysis was carried out by RevMan 5.3 software.Results:The results of meta-analysis showed that the positive rate of HSV-2 was higher in the adverse pregnancy group than in the control group(odds ratio[OR]:7.92,95%confidence interval[Cl]:3.91-16.01),and the difference was statistically significant.Conclusion:HSV-2 infection will increase the risk of adverse pregnancy outcomes.Prevention and effective control of HSV-2 infection in early pregnancy can reduce the rate of adverse pregnancy outcome,which is of great significance to the promotion of eugenics.
基金supported by Joint Fund of Ministry of Education for Equipment Pre-research(8091B022230)the Fundamental Research Funds for the Central Universities(2042022kf1220)+1 种基金National Natural Science Foundation of China(62161160311,51973165)Open Fund of Hubei Key Laboratory of Electronic Manufacturing and Packaging Integration(Wuhan University)(EMPI2023020).
文摘Comprehensive Summary,In nature,fishes have evolved functional skins with effective hydrodynamic performance and anti-fouling,facilitating predation and escaping from predators.Although a large number of fish scale-inspired structured surfaces have been explored,the incorporation of mucus on the structured surfaces has been largely ignored.Inspired by the skin of Osteichthyes fishes,a Janus hydrogel coating(JHC)is successfully prepared by a two-step UV light irradiation at room temperature.The bottom side of JHC(STH)achieves a shear adhesive strength of 103.3±17.5 kPa and can strongly adhere to a large variety of surfaces,including metals,ceramic and polymers.The top surface of JHC(SLH)replicates the structure of cycloid scales,while the nature of hydrogel mimics the mucus on fish skin.SLH possesses prominent mechanical,anti-swelling,anti-fouling and drag reduction properties.The design strategy for JHC has potential applications in numerous fields,like,pipeline transportation,bioengineering,and shipping industry.
基金financial support from the National Natural Science Foundation of China(Grant No.52160003 and 52264039)the State Key Laboratory of Urban Water Resource and Environment at Harbin Institute of Technology(2020DX05)+2 种基金Natural Science Foundation of Gansu Province(Grant No.20JR5RA436)the National Key Research&Development Program of China(2022YFC3203101)Foster Foundation of International Research Base of Seismic Mitigation and Isolation of Gansu Province(No.GII2022-P02).
文摘Membrane capacitive deionization(MCDI)is a cost-effective desalination technique known for its low energy consumption.The performance of MCDI cells relies on the properties of electrode materials.Activated carbon is the most widely used electrode material.However,the capacitive carbon available on the market is often expensive.Here,we developed hierarchically porous biochar by combining carbonization and activation processes,using easily acquired aerobic granular sludge(AGS)from biological sewage treatment plants as a precursor.The biochar had a specific surface area of 1822.07 m^(2)g^(-1),with a micropore area ratio of 58.65%and a micropore volume of 0.576 cm3 g^(-1).The MCDI cell employing the biochar as electrodes demonstrated a specific adsorption capacity of 34.35 mg g^(-1),comparable to commercially available activated carbon electrodes.Our study presents a green and sustainable approach for preparing highly efficient,hierarchically porous biochar from AGS,offering great potential for enhanced performance in MCDI applications.
基金the National Natural Science Foundation of China(81573412)the Key Research and Development Plan(2018GSF121004)the Natural Science Foundation of Shandong Province,China(ZR2014JL055).
文摘Previous studies have suggested that thrombospondin-1(TSP-1) regulates the transforming growth factor beta 1(TGF-b1)/phosphorylated Smad2/3(p Smad2/3) pathway. Moreover, TSP-1 is closely associated with epilepsy. However, the role of the TSP-1-regulated TGFb1/p Smad2/3 pathway in seizures remains unclear. In this study, changes in this pathway were assessed following kainic acid(KA)-induced status epilepticus(SE) in rats.The results showed that increases in the TSP-1/TGF-b1/p Smad2/3 levels spatially and temporally matched the increases in glial fibrillary acidic protein(GFAP)/chondroitin sulfate(CS56) levels following KA administration.Inhibition of TSP-1 expression by small interfering RNA or inhibition of TGF-b1 activation with a Leu-Ser-Lys-Leu peptide significantly reduced the severity of KA-induced acute seizures. These anti-seizure effects were accompanied by decreased GFAP/CS56 expression and Smad2/3 phosphorylation. Moreover, inhibiting Smad2/3 phosphorylation with ponatinib or SIS3 also significantly reduced seizure severity, alongside reducing GFAP/CS56 immunoreactivity. These results suggest that the TSP-1-regulated TGF-b1/p Smad2/3 pathway plays a key role in KA-induced SE and astrogliosis, and that inhibiting this pathway may be a potential anti-seizure strategy.
基金Thanks to the financial supports provided by the Natural Science Foundation of Zhejiang Province(LY17E090007,LQ18G010007,and LY19E90006)the National Natural Science Foundation of China(Grant No.51279181).
文摘Permeability is a major indicator of concrete durability,and depends primarily on the microstructure characteristics of concrete,including its porosity and pore size distribution.In this study,a variety of concrete samples were prepared to investigate their microstructure characteristics via nuclear magnetic resonance(NMR),mercury intrusion porosimetry(MIP),and X-ray computed tomography(X-CT).Furthermore,the chloride diffusion coefficient of concrete was measured to explore its correlation with the microstructure of the concrete samples.Results show that the proportion of pores with diameters<1000 nm obtained by NMR exceeds that obtained by MIP,although the difference in the total porosity determined by both methods is minimal.X-CT measurements obtained a relatively small porosity;however,this likely reflcts the distribution of large pores more accurately.A strong correlation is observed between the chloride diffusion coefficient and the porosity or contributive porosity of pores with sizes<1000 nm.Moreover,microstructure parameters measured via NMR reveal a lower correlation coefficient R2 versus the chloride diffusion coefficient relative to the parameters determined via MIP,as NMR can measure non-connected as well as connected pores.In addition,when analyzing pores with sizes>50 um,X-CT obtains the maximal contributive porosity,followed by MIP and NMR.
基金This work was financially supported by the“Key Program for International S&T Cooperation Projects of China”(No.2017YFE0124300)Anhui Provincial Natural Science Foundation of China(No.2008085M47)Key Projects of the Department of Education of Anhui Province of China(No.RZ2000003450).
文摘Developing highly efficient and recyclable photocatalysts through harvesting solar light as energy is crucial to oxidation for industrial implementation,especially for simple transition metal oxidic catalysts without precious/heavy/rare metal dopants.Herein,we like to report the use of nitrogen-doped CoMn_(2)O_(4) oxide(N–CoMn_(2)O_(4))as a heterogeneous catalyst for efficient oxidation of various alcohols such as p/m/o-methyl-substituted aromatic alcohols,p-substituted aromatic alcohols including electron-donating and electron-withdrawing substituents,heterocycle-based alcohols and secondary aromatic alcohols to the corresponding aldehydes/ketones,under visible light(>420 nm)illumination and mild condition of oxygen as oxidant and room temperature.The relation of various Co-based oxides to their catalytic performance was studied.It is shown that the Co^(2+)species in N–CoMn_(2)O_(4),obviously increased by the doping of nitrogen,are acted as catalytic active species coupled with the synergistic effect between Co and Mn species for the enhanced visible-light selective oxidation of alcohols to aldehydes.A plausible catalytic mechanism is proposed basis of control experiments and published studies,which suggests that this oxidation process probably occurs on Co^(2+)þsites via an ionic reactive oxygen species pathway and ^(1)O2 and O2⋅^(-)species are the reactive oxygen species.This simple transition metal oxide-catalyzed aerobic oxidation provides a green alternative for the manufacture of aldehydes/ketones from alcohols.
基金funded by grants from Hebei Social Sciences Fund,China(grant number:HB19GL026).
文摘China has achieved commendable success in stabilizing human immunodeficiency virus(HIV)prevalence at a relatively low level of transmission(1).Nevertheless,the total number of people living with HIV in China rose to approximately 1.05 million,with cumulative reported acquired immune deficiency syndrome(AIDS)-related fatalities reaching 351,000 by the end of 2020(2).Since the initial infiltration of HIV into China in 1982(3),the nation has enacted over 471 national policies through 2021 to combat the epidemic.Initially,the outbreak was perceived primarily as a healthcare issue rather than the complex societal challenge that it manifested into.The Ministry of Health(MOH,now known as National Health Commission)was initially tasked with HIV prevention,issuing the nation’s first HIV/AIDS-related policy in 1984,which aimed to ban HIV-infected products and individuals from entry.Regrettably,this approach proved inadequate as significant HIV outbreaks unfolded.At this juncture,the State Council Research Office recognized the HIV epidemic as a grave societal and public health issue,posing a threat to the“Survival of the Chinese Nation”(4).Engagement at a higher governmental level became imperative to coordinate an effective response across diverse administrative agencies.