Shallow needling on Neiguan and Gongsun acupoints in rats with brain ischemia Changes in apoptosis regulating genes and vasoactive substances

For the treatment of brain ischemia using acupuncture, the needle is predominantly inserted into muscular layers and deep tissue. However, few studies have investigated the outcomes of shallow needling. The present study established middle cerebral artery occlusion models in rats using the thrombosis method. Shallow needling and conventional needling at the bilateral Neiguan （PC 6） and Gongsun （SP 4） acupoints improved neurological function of middle cerebral artery occlusion rats, increased the expression of the anti-apoptotic Bcl-2, inhibited the expression of the pro-apoptotic Bax, and reduced the expression of the vasoactive substances nitric oxide synthase and endothelin-1. However, these changes were more pronounced in the shallow needling group, indicating that shallow needling is more effective in inhibiting brain ischemic injury.

基于数据挖掘探讨针灸治疗产后尿失禁选穴规律

目的运用数据挖掘技术探讨针灸治疗产后尿失禁的选穴规律。方法检索中国期刊全文数据库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(重庆维普)、中国生物医学文献数据库(CBM)、中华医学期刊全文数据库、PubMed、Embase、Web of Science建库至2023年2月1日有关针灸治疗产后尿失禁的临床研究文献, 采用Excel 2016软件建立腧穴处方数据库并进行腧穴、归经和特定穴频次统计, 分别采用SPSS Statistics 25.0软件、SPSS Modeler 18.0软件对腧穴进行聚类分析与关联规则分析。结果共纳入文献70篇, 涉及针灸处方70首, 包含腧穴31个, 总频次384次。使用频次排名前5位的腧穴依次为三阴交(46次)、关元(45次)、足三里(43次)、中极(41次)和气海(38次), 常用经脉为任脉、足太阳膀胱经和足太阴脾经, 腧穴多位于下肢部和腹部, 特定穴以交会穴、募穴和五输穴居多。高频腧穴聚类分析得到5个有效聚类群。关联规则分析得到核心腧穴组合为三阴交-足三里-关元-气海-中极。结论产后尿失禁病机以气虚为主, 针灸治疗基于益气健脾、养肺补肾治法, 注重腹部和下肢部腧穴的使用, 并运用上下配穴、前后配穴等配穴方法。